师资

EN       返回上一级       师资搜索
王松灵
讲席教授
中国科学院院士
南方科技大学医学院院长,南方科技大学伦敦国王学院医学院院长
wangsl@sustech.edu.cn

个人简介

王松灵,中国科学院院士,中国医学科学院学部委员,全国政协委员优秀履职奖获奖者,教授、主任医师。南方科技大学医学院院长,南方科技大学伦敦国王学院医学院院长,首都医科大学健康大数据国家研究院院长,中华口腔医学会副会长,北京医学会副会长,口腔健康北京实验室主任。国务院学位委员会第八届口腔医学召集人;第六届全国口腔教材评审委员会主任委员;《中华口腔医学杂志》总编辑、 Current Medicine 主编、《医学教育管理》主编、 《今日口腔》主编。发表论文249篇,其中以主要作者发表英文论文167篇。 第一完成人获2003及2010年国家科技进步二等奖两项;获威廉盖茨(William J. Gies)奖、吴阶平医药创新奖、何梁何利科学技术奖。研究方向为唾液腺与牙再生。发现人细胞膜硝酸盐转运通道,该通道与硝酸盐对维持机体稳态有重要作用,提出稳态医学的概念,研发基于硝酸盐的耐瑞特新药;揭示牙发育新机制,研发牙髓干细胞新药,成功实现生物性牙齿再生。

在2021年度全国政协委员优秀履职奖的颁奖词中是这么评价王松灵院士的:“一支笔写提案,践行委员责任推进慢病防治纳入重大科技专项,精准建言推动医学科技成果转化。一支笔写教案,传道授业解惑培养杏坛翘楚。悬壶济世的医者、立德树人的师者,更是协商议政的行家里手。”以此为他对中国医学事业的建设及口腔医学的创新发展做出的突出贡献进行表彰及肯定。


研究领域

研究方向为唾液腺与牙再生,发现人细胞膜硝酸盐转运通道,该通道与硝酸盐对维持机体稳态有重要作用,提出稳态医学的概念,研发基于硝酸盐的耐瑞特新药;揭示牙发育新机制,研发牙髓干细胞新药,成功实现生物性牙齿再生。


教育背景

  • 1979年9月-1984年7月  北京大学口腔医学院    口腔医学    本科    

  • 1984年7月-1989年7月  北京大学口腔医学院    口腔颌面外科及口腔放射    硕士/博士

  • 1991年4月-1992年4月  日本东京医科齿科大学研究生院    口腔医学    访问学者    

  • 1996年11月-1998年5月  美国国立卫生研究院(NIH)    口腔生物医学    高级访问学者    

  • 2001年5月2001年9月  美国国立卫生研究院(NIH)    国立牙颅颌研究所(NIDCR) 口腔生物医学    高级访问学者    


工作经历

  • 1989年9月-1996年10月    

    首都医科大学附属北京口腔医院放射科    主治医师、副主任、副主任医师、副教授

  • 1996年10月-至今  

    首都医科大学附属北京口腔医院 北京口腔医学研究所    副所长、主任医师、教授

  • 1999年4月-2005年2月

    首都医科大学附属北京口腔医院    副院长    

  • 2005年3月-至今

    首都医科大学基础医学院生物化学与分子生物学系    副校长(2005-2022)一级教授(2019-)

  • 2020年-至今

    首都医科大学健康医疗大数据国家研究院    院长    

  • 2011年9月-2013年3月

    北京市卫生局    副局长(挂职)    

  • 2019年10月-至今

    教育部    国家督学    

  • 2023年10月-至今

    南方科技大学医学院院长


获奖情况及荣誉

  • 第一完成人获2003及2010年国家科技进步二等奖两项

  • 2018年北京市科技进步一等奖

  • 获国际口腔权威的威廉盖茨(William J. Gies)奖

  • 获吴阶平医药创新奖

  • 中源协和生命医学奖-成就奖、干细胞转化成果奖、何梁何利奖

  • 入围Elsevier“中国高被引学者”榜

  • 当选英国皇家外科学院(爱丁堡)杰出Fellow

  • 口腔医学界首位获国家杰出青年科学基金学者

  • 首批入选北京学者

  • 获国家发明专利授权19项,美国发明专利授权4项

  • 牵头制定我国口腔医学本科教育及实践教育标准,为促进口腔教育健康发展做出重要贡献。

  • 迄今已培养研究生126人,其中“国家杰出青年科学基金”和“国家优秀青年科学基金”获得者4人。

  • 主编《唾液腺非肿瘤疾病》、《口腔颌面疾病临床X线表现及其病理学基础》等学术专著和《口腔医学》、《口腔分子生物学与口腔实验动物模型》等本科生和研究生规划教材。


近年代表文章

发表论文249篇,其中以通讯作者发表英文论文177篇,英文review article 16篇,主编教科书及专著22本。

  1. Chang, S., Hu, L., Xu, Y., Li, X., Ma, L., Feng, X., Wang, J., Zhang, C., & Wang, S. (2019). Inorganic nitrate alleviates total body irradiation-induced systemic damage by decreasing reactive oxygen species levels. International journal of radiation oncology, biology, physics, 103(4), 945–957.

  2. Ding, G., Liu, Y., Wang, W., Wei, F., Liu, D., Fan, Z., An, Y., Zhang, C., & Wang, S. (2010). Allogeneic periodontal ligament stem cell therapy for periodontitis in swine. Stem cells (Dayton, Ohio), 28(10), 1829–1838.

  3. Feng, X., Wu, Z., Xu, J., …… Wang, S. (2021). Dietary nitrate supplementation prevents radiotherapy-induced xerostomia. eLife. 2021b. https:// doi. org/10. 7554/ eLife. 70710.

  4. Feng, Y., Cao, X., Zhao, B., …… Hu, J.Q., Wang, S. (2021) Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway. Sci China Life Sci. https:// doi. org/ 10. 1007/s11427- 020- 1978-4.

  5. Gao, Z. H., Hu, L., Liu, G. L., Wei, F. L., Liu, Y., Liu, Z. H., Fan, Z. P., Zhang, C. M., Wang, J. S., & Wang, S. L. (2016). Bio-root and implant-based restoration as a tooth replacement alternative. Journal of dental research, 95(6), 642–649.

  6. Hu, J., Cao, Y., Xie, Y., Wang, H., Fan, Z., Wang, J., Zhang, C., Wang, J., Wu, C. T., & Wang, S. (2016). Periodontal regeneration in swine after cell injection and cell sheet transplantation of human dental pulp stem cells following good manufacturing practice. Stem cell research & therapy, 7(1), 130.

  7. Hu, L., Jin, L., Xia, D., Zhang, Q., Ma, L., Zheng, H., Xu, T., Chang, S., Li, X., Xun, Z., Xu, Y., Zhang, C., Chen, F., & Wang, S. (2020). Nitrate ameliorates dextran sodium sulfate-induced colitis by regulating the homeostasis of the intestinal microbiota. Free radical biology & medicine, 152, 609–621.

  8. Hu, L., Xu, J., Wu, T., Fan, Z., Sun, L., Liu, Y., Li, Y., Zhang, C., Wang, J., Ding, Y., & Wang, S. (2020). Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren's syndrome. Cell death & disease, 11(3), 172.

  9. Hu, L., Zhu, Z., Hai, B., Chang, S., Ma, L., Xu, Y., Li, X., Feng, X., Wu, X., Zhao, Q., Qin, L., Wang, J., Zhang, C., Liu, F., & Wang, S. (2018). Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model. Theranostics, 8(16), 4321–4331.

  10. Jin, L., Qin, L., Xia, D., Liu, X., Fan, Z., Zhang, C., Gu, L., He, J., Ambudkar, I. S., Deng, D., & Wang, S. (2013). Active secretion and protective effect of salivary nitrate against stress in human volunteers and rats. Free radical biology & medicine, 57, 61–67.

  11. Li, J., Shan, Z., Ou, G., Liu, X., Zhang, C., Baum, B. J., & Wang, S. (2005). Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig. International journal of radiation oncology, biology, physics, 62(5), 1510–1516.

  12. Li, S., Jin, H., Sun, G., Zhang, C., Wang, J., Xu, H., Zhang, D., & Wang, S. (2021). Dietary inorganic nitrate protects hepatic ischemia-reperfusion injury through NRF2-mediated antioxidative stress. Frontiers in pharmacology, 12, 634115.

  13. Li, X.Y., …… Wang, S. (2024). Discovery of Sialin2 as the sensor of nitrate in the organelle membrane.

  14. Liu, O., Xu, J., Ding, G., Liu, D., Fan, Z., Zhang, C., Chen, W., Ding, Y., Tang, Z., & Wang, S. (2013). Periodontal ligament stem cells regulate B lymphocyte function via programmed cell death protein 1. Stem cells (Dayton, Ohio), 31(7), 1371–1382.

  15. Liu, Y., Hu J.T., Liu Y.T., …… Wu Z.Z., Wang, S. Clinical study and a phase I  clinical trial of allogeneic human dental pulp stem cells injection in the treatment of chronic periodontitis.

  16. Liu, Y., Zheng, Y., Ding, G., Fang, D., Zhang, C., Bartold, P. M., Gronthos, S., Shi, S., & Wang, S. (2008). Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem cells (Dayton, Ohio), 26(4), 1065–1073.

  17. Ma, L., Hu, L., Jin, L., Wang, J., Li, X., Wang, W., Chang, S., Zhang, C., Wang, J., & Wang, S. (2020). Rebalancing glucolipid metabolism and gut microbiome dysbiosis by nitrate-dependent alleviation of high-fat diet-induced obesity. BMJ open diabetes research & care, 8(1), e001255.

  18. Ma, L., Hu, J., Cao, Y., Xie, Y., Wang, H., Fan, Z., Zhang, C., Wang, J., Wu, C. T., & Wang, S. (2019). Maintained properties of aged dental pulp stem cells for superior periodontal tissue regeneration. Aging and disease, 10(4), 793–806.p

  19. Qin, L., Liu, X., Sun, Q., Fan, Z., Xia, D., Ding, G., Ong, H. L., Adams, D., Gahl, W. A., Zheng, C., Qi, S., Jin, L., Zhang, C., Gu, L., He, J., Deng, D., Ambudkar, I. S., & Wang, S. (2012). Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13434–13439.

  20. Pan,W., Hu, G., Li, S.R., …… Wang, X.G., Wang, Y.J., Wang, S. (2023). Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on swarm learning approach. Science Bulletin,, 68: 838–850.

  21. Shan, Z., Li, J., Zheng, C., Liu, X., Fan, Z., Zhang, C., Goldsmith, C. M., Wellner, R. B., Baum, B. J., & Wang, S. (2005). Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Molecular therapy : the journal of the American Society of Gene Therapy, 11(3), 444–451.

  22. Song, T., Wu, T., Wei, F., Li, A., Wang, F., Xie, Y., Liu, D., Fan, Z., Wang, X., Cheng, S., Zhang, C., He, J., & Wang, S. (2014). Construction of a cDNA library for miniature pig mandibular deciduous molars. BMC developmental biology, 14, 16.

  23. Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B. M., Zhang, C., Liu, H., Gronthos, S., Wang, C. Y., Wang, S., & Shi, S. (2006). Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS one, 1(1), e79.

  24. Wang, F., Wu, Z., Fan, Z., Wu, T., Wang, J., Zhang, C., & Wang, S. (2018). The cell re-association-based whole-tooth regeneration strategies in large animal, Sus scrofa. Cell proliferation, 51(4), e12479.

  25. Wang, F., Xiao, J., Cong, W., Li, A., Song, T., Wei, F., Xu, J., Zhang, C., Fan, Z., & Wang, S. (2014). Morphology and chronology of diphyodont dentition in miniature pigs, Sus Scrofa. Oral diseases, 20(4), 367–379.

  26. Wang, F., Xiao, J., Cong, W., Li, A., Wei, F., Xu, J., Zhang, C., Fan, Z., He, J., & Wang, S. (2014). Stage-specific differential gene expression profiling and functional network analysis during morphogenesis of diphyodont dentition in miniature pigs, Sus Scrofa. BMC genomics, 15, 103.

  27. Wang, H., Hu, L., Li, L., Wu, X., Fan, Z., Zhang, C., Wang, J., Jia, J., & Wang, S. (2018). Inorganic nitrate alleviates the senescence-related decline in liver function. Science China Life Sciences, 61(1), 24–34.

  28. Wang, S., Qin, L.Z. (2022) Homeostatic medicine: a strategy for exploring health and disease. Current Medicine, 1:16 (https://doi.org/10.1007/s44194-022-00016-9).

  29. Wang, W., Hu, L., Chang, S., Ma, L., Li, X., Yang, Z., Du, C., Qu, X., Zhang, C., & Wang, S. (2020). Total body irradiation-induced colon damage is prevented by nitrate-mediated suppression of oxidative stress and homeostasis of the gut microbiome. Nitric oxide : biology and chemistry, 102, 1–11.

  30. Wei, F., Song, T., Ding, G., Xu, J., Liu, Y., Liu, D., Fan, Z., Zhang, C., Shi, S., & Wang, S. (2013). Functional tooth restoration by allogeneic mesenchymal stem cell-based bio-root regeneration in swine. Stem cells and development, 22(12), 1752–1762.

  31. Wu, X., Hu, J., Li, G., Li, Y., Li, Y., Zhang, J., Wang, F., Li, A., Hu, L., Fan, Z., Lü, S., Ding, G., Zhang, C., Wang, J., Long, M., & Wang, S. (2020). Biomechanical stress regulates mammalian tooth replacement via the integrin β1-RUNX2-Wnt pathway. The EMBO journal, 39(3), e102374.

  32. Wu, Y., Zhang, J., Peng, B., Tian, D., Zhang, D., Li, Y., Feng, X., Liu, J., Li, J., Zhang, T., Liu, X., Lu, J., Chen, B., & Wang, S. (2019). Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos. Nature communications, 10(1), 2883.

  33. Wu, Z., Wang, F., Fan, Z., Wu, T., He, J., Wang, J., Zhang, C., & Wang, S. (2019). Whole-tooth regeneration by allogeneic cell reassociation in pig jawbone. Tissue engineering. Part A, 25(17-18), 1202–1212.

  34. Xia, D. S., Deng, D. J., & Wang, S. L. (2003). Destruction of parotid glands affects nitrate and nitrite metabolism. Journal of dental research, 82(2), 101–105.

  35. Xu, J., Wang, D., Liu, D., Fan, Z., Zhang, H., Liu, O., Ding, G., Gao, R., Zhang, C., Ding, Y., Bromberg, J. S., Chen, W., Sun, L., & Wang, S. (2012). Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome. Blood, 120(15), 3142–3151.

  36. Zhu, Z., Pang, B., Iglesias-Bartolome, R., Wu, X., Hu, L., Zhang, C., Wang, J., Gutkind, J. S., & Wang, S. (2016). Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands. Oncotarget, 7(15), 20271–20281.