个人简介：

闫凯歌，2011年毕业于南开大学物理科学学院，取得学士学位。同年加入清华大学高宁教授和雷建林教授课题组攻读博士，于2016年获得生物学博士学位。之后加入英国剑桥MRC分子生物学实验室英国皇家学会院士David Barford课题组从事博士后研究。自2010年起，闫博士一直从事结构生物学领域的研究，多次以第一作者在Nature, Nature Structural & Molecular Biology, Nucleic Acids Research等国际顶级期刊发表重要研究成果。2020年10月加入南方科技大学生物系。

研究领域：

主要利用冷冻电镜三维重构技术、生物化学、分子生物学和细胞生物学手段进行大分子机器的结构和功能研究。实验室的主要研究方向包括：

1. 着丝点(动粒)组装机制的研究；

2. 核酸蛋白大分子复合物工作机制的研究。

工作经历：

2020至今 南方科技大学生物系 助理教授

2016-2020 英国剑桥MRC分子生物学实验室 博士后

学习经历：

2011-2016 清华大学 生命科学学院 博士

2007-2011 南开大学 物理科学学院 学士

代表文章：

1. Yan, K. †, Yang, J. †, Zhang, Z. †, McLaughlin, S.H., Chang, L., Fasci, D., Ehrenhofer-Murray, A.E., Heck, A.J.R. and Barford, D.. (2019) Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome. Nature, 574, 278-282. († contributed equally to this work).

2. Yan, K. †,Zhang, Z. †, Yang, J., McLaughlin, S.H. and Barford, D.. (2018) Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nature structural & molecular biology, 25, 1103-1110.

3. Zhang, D. †, Yan, K.†, Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Lou, J., Gao, N. and Qin, Y.. (2016) EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. Nature structural & molecular biology, 23, 125-131.

4. Zhang, D. †, Yan, K.†, Zhang, Y. †, Liu, G., Cao, X., Song, G., Xie, Q., Gao, N. and Qin, Y.. (2015) New insights into the enzymatic role of EF-G in ribosome recycling. Nucleic acids research, 43, 10525-10533.

5. Zhang, X. †, Yan, K.†, Zhang, Y., Li, N., Ma, C., Li, Z., Feng, B., Liu, J., Sun, Y., Xu, Y., Lei, J. and Gao, N.. (2014) Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly. Nucleic acids research, 42, 13430-13439.

6. Wang, W., Li, W., Ge, X., Yan, K., Mandava, C.S., Sanyal, S. and Gao, N.. (2020) Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation. Proc Natl Acad Sci U S A, 117, 15609-15619.

7. Ma, C., Wu, S., Li, N., Chen, Y., Yan, K., Li, Z., Zheng, L., Lei, J., Woolford, J.L.J. and Gao, N.. (2017) Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1. Nature structural & molecular biology, 24, 214-220.

8. Wu, S., Tutuncuoglu, B., Yan, K., Brown, H., Zhang, Y., Tan, D., Gamalinda, M., Yuan, Y., Li, Z., Jakovljevic, J., Ma, C., Lei, J., Dong, M., Woolford, J.L.J. and Gao, N.. (2016) Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature, 534, 133-137.

9. Gu, J., Wu, M., Guo, R., Yan, K., Lei, J., Gao, N. and Yang, M.. (2016) The architecture of the mammalian respirasome. Nature, 537, 639-643.

10. Ma, C., Yan, K., Tan, D., Li, N., Zhang, Y., Yuan, Y., Li, Z., Dong, M., Lei, J. and Gao, N.. (2016) Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation.Protein & cell. 7,187-200.

11. Zhang, J., Pan, X., Yan, K., Sun, S., Gao, N. and Sui, S.F.. (2015) Mechanisms of ribosome stalling by SecM at multiple elongation steps. eLife, 4.

12. Yang, Z., Guo, Q., Goto, S., Chen, Y., Li, N., Yan, K., Zhang, Y., Muto, A., Deng, H., Himeno, H., Lei, J. and Gao, N.. (2014) Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence. Protein & cell, 5, 394-407.