个人简介：

理学博士，2013年获东北师范大学博士学位，主要从事肿瘤发生，发展和转移的分子机制研究，涉及生物化学、分子生物学，细胞生物学多个学科领域。目前发表学术论文13篇，包括第一作者论文Cancer Research（2012）、Oncogene（2020）、Oncotarget（2016）、BBRC（2013）等论文。主持国家自然科学基金1项，中国博士后科学基金1项，广东省自然科学基金1项，深圳市科技项目2项；获得吉林省科学技术奖一等奖1项、吉林省自然科学学术成果二等奖1项、2015年吉林省优秀博士学位论文以及2012年博士生国家奖学金。

教育背景：

2008.09-2013.06年：东北师范大学，生命科学学院，细胞生物学专业，博士

2004.09-2008.06年：廊坊师范学院，生命科学学院，生物科学专业，本科

工作经历：

2021.01-现在：南方科技大学，医学院，研究助理教授

2017.04-2020.12：深圳大学，医学部，副研究员

2014.10-2017.04：中国科学院深圳先进技术研究院，医药所，博士后/助理研究员

2014.05-2014.09：徐州医学院，助理研究员

2013.09-2014.03：美国国家癌症研究中心，博士后

获奖情况及荣誉：

2017年11月，吉林省科学技术奖一等奖 排名第四

2015年10月，吉林省自然科学学术成果二等奖 排名第四

2015年10月，2015年吉林省优秀博士学位论文

2013年06月，东北师范大学2013年度博士生科研奖一等奖

2013年06月，东北师范大学优秀毕业研究生

2012-2013学年，东北师范大学优秀研究生

2012-2013学年，东北师范大学研究生优秀奖学金

2012年12月，教育部博士生国家奖学金

2011-2012学年，东北师范大学研究生优秀奖学金

2009-2010学年，东北师范大学学术活动先进个人

2009-2010学年，东北师范大学研究生优秀奖学金

研究领域：

肿瘤发生和转移的分子机制

发表论文：

(1) Jianchao Zhang, Xinxin Lin, Liufeng Wu, Jia-Jia Huang, Wen-qi Jiang, Thomas Kipps, and Suping Zhang, Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis. Oncogene, 2020, 39(12):2550-2567.

(2) Jianchao Zhang, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun Li and Hongchang Li, NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 2016, 7(38):61036-53.

(3) Jianchao Zhang, Qian Liang, Yang Lei, Min Yao, Lili Li, Xiaoge Gao, Jingxin Feng, Yu Zhang, Hongwen Gao, Dong-Xu Liu, Jun Lu, and Baiqu Huang, SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Research, 2012, 72(17):4597-608.

(4) Jianchao Zhang, Yang Lei, Xiaoge Gao, Qian Liang, Lili Li, Jingxin Feng, Yu Zhang, Baiqu Huang, and Jun Lu, p53 attenuates the oncogenic ras-induced epithelial-mesenchymal transition in human mammary epithelial cells. Biochemical and Biophysical Research Communications, 2013, 434(3):606-13.

(5) Suping Zhang, Han Zhang, Emanuela M. Ghia, Jiajia Huang, Liufeng Wu, Jianchao Zhang, Sharon Lam, Yang Lei, Jinsong He, Bing Cui, George F. Widhopf II, Jian Yu, Richard Schwab, Karen Messer, Wenqi Jiang, Barbara A. Parker, Dennis A. Carson, and Thomas J. Kipps, Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. Proc Natl Acad Sci U S A, 2019, 116(4):1370-1377.

(6) Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li and Huashun Li, Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Research, 2016, 26(5):593-612.

(7) Qian Liang, Lili Li, Jianchao Zhang, Yang Lei, Liping Wang, Dong-Xu Liu, Jingxin Feng, Pingfu Hou, Ruosi Yao, Yu Zhang, Baiqu Huang, and Jun Lu, CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Scientific Reports. 2013, 14;3:2932.

(8) Jingxin Feng, Guiying Xu, Jiwei Liu, Na Zhang, Lili Li, Jiafei Ji, Jianchao Zhang, Lian Zhang, Guannan Wang, Xiuli Wang, Jiang Tan, Baiqu Huang, Jun Lu, Yu Zhang, Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. Breast Cancer Research and Treatment. 2016, 159(3):443-56.

(9) Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su, and Hongchang Li, Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo. Molecular Cancer Therapeutics, 2018, 17(5):988-1002.

(10) Ke Liu, Run Lei, Qiong Li, Xin-Xin Wang, Qian Wu, Peng An, Jianchao Zhang, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang Li, and Huashun Li, Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Scientific Reports. 2016, 16;6:21019.

(11) Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang Li, Huashun Li, Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters. 2015, 597:97-103.

(12) Yu Zhang, Yanyan Gao, Guoping Zhang, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao Zhang, Jun Lu and Baiqu Huang, DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. International Journal of Cancer, 2011, 128:551-61.

(13) Dongmei Su, Xiue Peng, Shan Zhu, Ying Huang, Zhixiong Dong, Yu Zhang, Jianchao Zhang, Qian Liang, Jun Lu, Baiqu Huang, Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cells. Biochemical Journal, 2010, 433(2):333-43.

(14) Hanqing Shi, Hui Huang, Xitao Zhang, Jianchao Zhang, Xiutan Luo, Xiue Peng, Baiqu Huang, Jun Lu, c-Myc attenuates the ability of doxorubicin to reduce the colony formation partially through regulating Nbs1 in U2OS cells. Progress in Biochemistry and Biophysics, 2010, 37(8):855-63.