Faculty
Education
06.2012 ̶ 07.2015: Ph.D in Chemistry University of Geneva, Switzerland (Advisor: Prof. Eric Bakker)
09.2010 ̶ 06.2012: Master in Chemistry University of Geneva, Switzerland
09.2004 ̶ 06.2008: Bachelor in Chemistry Nanjing University, China
Research Experiences
10.2016 ̶ now: Associate Professor South University of Science and Technology of China
02.2016 ̶ 09.2016: Postdoc Funded by The Swiss National Science Foundation École normale supérieure – Paris (ENS Paris)
University Pierre et Marie Curie (UPMC)
Centre national de la recherche scientifique (CNRS) Advisor: Prof. Ludovic Jullien
07.2015 ̶ 01.2016: Postdoc Researcher University of Geneva, Switzerland, Advisor: Prof. Eric Bakker
12.2008 ̶ 08.2010: Analytical Chemist, Nanjing University, China
06.2008 ̶ 11.2008: Organic Chemist WuXi Apptech, Shanghai, China
Representative Publication
(56) Qinghan Chen, Xiaoang Li, Renjie Wang, Fanxin Zeng, Jingying Zhai*, Xiaojiang Xie*, “Rapid Equilibrated Colorimetric Detection of Protamine and Heparin: Recognition at the Nanoscale Liquid–Liquid Interface”, Anal. Chem. 2019, 91, 10390
(55) Lu Wang, Stephanie Sadler, Tianchi Cao, Xiaojiang Xie, Joachim Moser Von Filseck, Eric Bakker* “Simplified Fabrication for Ion-Selective Optical Emulsion Sensor with Hydrophobic Solvatochromic Dye Transducer: A Cautionary Tale”, Anal. Chem. 2019, 91, 8973
(54) Li Deng, Jingying Zhai, and Xiaojiang Xie* “A Chemiluminescent Ion Sensing Platform Based on Ionophores”, Anal. Chem. 2019, 91, 8638
(53) Renjie Wang, Xinfeng Du, Jingying Zhai, and Xiaojiang Xie* “Distance and Color Change Based Hydrogel Sensor for Visual Quantitative Determination of Buffer Concentrations”, ACS Sens. 2019, 4, 1017
(52) Wenyue Gao, Stéphane Jeanneret, Dajing Yuan, Thomas Cherubini, Lu Wang, Xiaojiang Xie*, and Eric Bakker* “Electrogenerated Chemiluminescence for Chronopotentiometric Sensors”, Anal. Chem., 2019, 91, 4889
(51) Fei Jia, Henrik Hupatz, Liu-Pan Yang, Hendrik V. Schröder, Dong-Hao Li, Shan Xin, Dieter Lentz, Felix Witte, Xiaojiang Xie, Beate Paulus, Christoph A. Schalley*, and Wei Jiang* “Naphthocage: A Flexible yet Extremely Strong Binder for Singly Charged Organic Cations”, J. Am. Chem. Soc.,2019,141 (10), 4468–4473
(50) Xinfeng Du, Manling Huang, Renjie Wang, Jingying Zhai, and Xiaojiang Xie*, A Rapid Point-of-Care Optical Ion Sensing Platform Based on Target-Induced Dye Release from Smart Hydrogels, Chem. Common., 2019, 55, 1774
(49) Renjie Wang, Xinfeng Du, Yaotian Wu, Jingying Zhai, and Xiaojiang Xie*, Graphene Quantum Dots Integrated in Ionophore-Based Fluorescent Nanosensors for Na+ and K+, ACS Sens., 2018, 3 (11), 2408
(48) Jingying Zhai, Liyuan Yang, Xinfeng Du, and Xiaojiang Xie* Electrochemical-to-Optical Signal Transduction for Ion-Selective Electrodes with Light-Emitting Diodes, Anal. Chem., 2018, 90 (21), 12791
(47) Changyou Zhu, Manling Huang, Jialing Lan, Lung Wa Chung, Xin Li*, and Xiaojiang Xie* Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode, ACS Omega, 2018, 3 (10), 12476
(46) Lu Wang, Xiaojiang Xie, Tianchi Cao, Jerôme Bosset, and Eric Bakker*, Surface-Doped Polystyrene Microsensors Containing Lipophilic Solvatochromic Dye Transducers, Chem. Eur. J. 2018, 24, 1
(45) Xinfeng Du, Liyuan Yang, WenChang Hu, Renjie Wang, Jingying Zhai, and Xiaojiang Xie*, A Plasticizer-Free Miniaturized Optical Ion Sensing Platform with Ionophores and Silicon-Based Particles, Anal. Chem. 2018, 90 (9), 5818
(44) Coll Crespi, M.; Crespo, G. A.; Xie, X.; Touilloux, R.; Tercier-Waeber, M.; Bakker, E*., Agarose hydrogel containing immobilized pH buffer microemulsion without increasing permselectivity, Talanta 2018, 177, 191
(43) Zhai, J.; Zhu, C.; Peng, X.; Xie, X.* Ionophore-based Heterogeneous Calcium Optical Titration. Electroanalysis, 2018, 30 (4), 705
(42) Querard, J.; Zhang, R.; Kelemen, Z.; Plamont, M.-A.; Xie, X.; Chouket, R.; Roemgens, I.; Korepina, Y.; Albright, S.; Ipendey, E.; Volovitch, M.; Sladitschek, H. L.; Neveu, P.; Gissot, L.; Gautier, A. Faure, J.-D.; Croquette, V.; Le Sausx, T.*; Jullien, L.* Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations. Nature Communications. 2017, 8 (1), 969
(41) Xinfeng Du, Xiaojiang Xie* Non-Equilibrium Diffusion Controlled Ion-Selective Optical Sensor for Blood Potassium Determination. ACS Sens. 2017, 2 (10), 1410
(40) Xinfeng Du, Changyou Zhu, Xiaojiang Xie* Thermochromic Ion-Exchange Micelles Containing H+ Chromoionophores. Langmuir 2017, 33 (23), 5910.
(39) Zhai, J.; Xie, X.; Cherubini, T.; Bakker, E.* Ionophore-Based Titrimetric Detection of Alkali Metal Ions in Serum. ACS Sens. 2017, 2 (4), 606.
(38) Xie, X.* Renovating the chromoionophores and detection modes in carrier-based ion-selective optical sensors. Anal. Bioanal. Chem. 2016, 408 (11), 2717.
(37) Xie, X.*; Zhai, J.; Jarolimova, Z.; Bakker, E.* Determination of pK(a) Values of Hydrophobic Colorimetric pH Sensitive Probes in Nanospheres. Anal. Chem. 2016, 88 (6), 3015.
(36) Wang, L.; Xie, X.; Zhai, J.; Bakker, E.* Reversible pH-independent optical potassium sensor with lipophilic solvatochromic dye transducer on surface modified microporous nylon. Chem. Commun. 2016, 52 (99), 14254.
(35) Xie, X.* Szilagyi, I; Zhai, J.; Wang, L.; Bakker, E.* Ion-Selective Optical Nanosensors Based on Solvatochromic Dyes of Different Lipophilicity: From Bulk Partitioning to Interfacial Accumulation. ACS Sens. 2016, 1 (5), 516
(34) Zhai, J.; Xie, X.; Bakker, E.* Ion-selective optode nanospheres as heterogeneous indicator reagents in complexometric titrations. Anal. Chem. 2015, 87 (5), 2827.
(33) Zhai, J.; Xie, X.; Bakker, E.* Anion-exchange nanospheres as titration reagents for anionic analytes. Anal. Chem. 2015, 87 (16), 8347.
(32) Zhai, J.; Xie, X.; Bakker, E.* Solvatochromic Dyes as pH-Independent Indicators for Ionophore Nanosphere-Based Complexometric Titrations. Anal. Chem. 2015, 87 (24), 12318.
(31) Xie, X.*; Gutierrez, A.; Trofimov, V.; Szilagyi, I.; Soldati, T.; Bakker, E.* Charged solvatochromic dyes as signal transducers in pH independent fluorescent and colorimetric ion selective nanosensors. Anal. Chem. 2015, 87 (19), 9954.
(30) Xie, X.*; Gutierrez, A.; Trofimov, V.; Szilagyi, I.; Soldati, T.; Bakker, E.* Potassium Sensitive Optical Nanosensors Containing Voltage Sensitive Dyes. Chimia 2015, 69 (4), 196.
(29) Xie, X.*; Bakker, E.* Ion selective optodes: from the bulk to the nanoscale. Anal. Bioanal. Chem. 2015, 407 (14), 3899.
(28) Xie, X.*; Bakker, E.* Determination of Effective Stability Constants of Ion-Carrier Complexes in Ion Selective Nanospheres with Charged Solvatochromic Dyes. Anal. Chem. 2015, 87 (22), 11587.
(27) Xie, X.; Crespo, G. A.; Mistlberger, G.; Bakker, E.* Photocurrent generation based on a light-driven proton pump in an artificial liquid membrane. Nat. Chem. 2014, 6 (3), 202.
(26) Zhai, J.; Xie, X.; Bakker, E.* Ionophore-based ion-exchange emulsions as novel class of complexometric titration reagents. Chem. Commun. 2014, 50 (84), 12659.
(25) Xie, X.; Zhai, J.; Bakker, E.* Potentiometric response from ion-selective nanospheres with voltage-sensitive dyes. J. Am. Chem. Soc. 2014, 136 (47), 16465.
(24) Xie, X.*; Bakker, E.* Photoelectric conversion based on proton-coupled electron transfer reactions. J. Am. Chem. Soc. 2014, 136 (22), 7857.
(23) Zhai, J.; Xie, X.; Bakker, E.* Advancing Schwarzenbach's Complexometry: Nano-scale Titration Reagents Based on Heterogeneous Reactions. Chimia 2014, 68 (12), 899.
(22) Xie, X.; Zhai, J.; Crespo, G. A.; Bakker, E.* Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode. Anal. Chem. 2014, 86 (17), 8770.
(21) Xie, X.; Zhai, J.; Bakker, E.* pH independent nano-optode sensors based on exhaustive ion-selective nanospheres. Anal. Chem. 2014, 86 (6), 2853.
(20) Xie, X.*; Crespo, G. A.; Zhai, J.; Szilagyi, I.; Bakker, E.* Potassium-selective optical microsensors based on surface modified polystyrene microspheres. Chem. Commun. 2014, 50 (35), 4592.
(19) Xie, X.*; Bakker, E.* Light-controlled reversible release and uptake of potassium ions from ion-exchanging nanospheres. ACS Appl. Mater. Interfaces 2014, 6 (4), 2666.
(18) Xie, X.*; Bakker, E.* Creating electrochemical gradients by light: from bio-inspired concepts to photoelectric conversion. Phys. Chem. Chem. Phys. 2014, 16 (37), 19781.
(17) Xie, X.; Mistlberger, G.; Bakker, E.* Visible light induced photoacid generation within plasticized PVC membranes for copper (II) ion extraction. Sensors and Actuators B: Chemical 2014, 204, 807
(16) Jarolimova, Z.; Crespo, G. A.; Xie, X.; Ghahraman Afshar, M.; Pawlak, M.; Bakker, E.* Chronopotentiometric carbonate detection with all-solid-state ionophore-based electrodes. Anal. Chem. 2014, 86 (13), 6307.
(15) Eric Bakker, Mary-Lou Tercier-Waeber, Thomas Cherubini, Miquel Coll Crespi, Gastón A Crespo, Maria Cuartero, Majid Ghahraman Afshar, Zdenka Jarolimova, Stéphane Jeanneret, Sandrine Mongin, Bastien Néel, Nadezda Pankratova, Romain Touilloux, Xiaojiang Xie, Jingying Zhai, Environmental Sensing of Aquatic Systems at the University of Geneva. Chimia 2014, 68 (11), 772.
(14) Afshar, M. G.; Crespo, G. A.; Xie, X.; Bakker, E.* Direct alkalinity detection with ion-selective chronopotentiometry. Anal. Chem. 2014, 86 (13), 6461.
(13) Xie, X.*; Bakker, E.* Detecting and manipulating ions. Q&More (Spotlight on: Bioanalytics | Ion Sensors ) 2014, 02.14
(12) Eric Bakker*, Mary-Lou Tercier-Waeber, Thomas Cherubini, Miquel Coll Crespi, Gastón A Crespo, Maria Cuartero, Majid Ghahraman Afshar, Zdenka Jarolimova, Stéphane Jeanneret, Sandrine Mongin, Bastien Néel, Nadezda Pankratova, Romain Touilloux, Xiaojiang Xie, Jingying Zhai, Environmental sensing of aquatic systems at the University of Geneva. CHIMIA International Journal for Chemistry, 2014, 68 (11), 772
(11) Xie, X.; Mistlberger, G.; Bakker, E.* Ultrasmall fluorescent ion-exchanging nanospheres containing selective ionophores. Anal. Chem. 2013, 85, 9932
(10) Xie, X.; Crespo, G. A.; Bakker, E.* Oxazinoindolines as fluorescent H+ turn-on chromoionophores for optical and electrochemical ion sensors. Anal. Chem. 2013, 85 (15), 7434
(9) Xie, X.; Bakker, E.* Non-Severinghaus potentiometric dissolved CO2 sensor with improved characteristics. Anal. Chem. 2013, 85 (3), 1332
(8) Mistlberger, G.*; Xie, X.; Pawlak, M.; Crespo, G. A.; Bakker, E.* Photoresponsive ion extraction/release systems: dynamic ion optodes for calcium and sodium based on photochromic spiropyran. Anal. Chem. 2013, 85 (5), 2983
(7) Eric Bakker*, Ewa Grygolowicz-Pawlak, Xiaojiang Xie, Günter Mistlberger, Gaston Crespo, Majid Afshar, Bastien Néel, Alexey Shvarev, Modern chemical ion sensor concepts based on electrochemically and optically triggered phase transfer. Anal. Chem., 2012, 66, 479
(6) Xie, X.; Pawlak, M.; Tercier-Waeber, M. L.; Bakker, E.* Direct optical carbon dioxide sensing based on a polymeric film doped with a selective molecular tweezer-type ionophore. Anal. Chem. 2012, 84 (7), 3163
(5) Xie, X.; Mistlberger, G.; Bakker, E.* Reversible photodynamic chloride-selective sensor based on photochromic spiropyran. J. Am. Chem. Soc. 2012, 134 (41), 16929
(4) Mistlberger, G.; Crespo, G. A.; Xie, X.; Bakker, E.* Photodynamic ion sensor systems with spiropyran: photoactivated acidity changes in plasticized poly(vinyl chloride). Chem. Commun. 2012, 48 (45), 5662
(3) Bakker, E.*; Crespo, G.; Grygolowicz-Pawlak, E.; Mistlberger, G.; Pawlak, M.; Xie, X. Advancing membrane electrodes and optical ion sensors. Chimia 2011, 65 (3), 141
(2) Xie, X.; Qin, Y.* A dual functional near infrared fluorescent probe based on the bodipy fluorophores for selective detection of copper and aluminum ions. Sensors and Actuators B: Chemical 2011, 156 (1), 213
(1) Xie, X.; Li, X.; Ge, Y.; Qin, Y.*; Chen, H.-Y. Rhodamine-based ratiometric fluorescent ion-selective bulk optodes. Sensors and Actuators B: Chemical 2010, 151 (1), 71