师资

姜凯
研究助理教授
0755-88018430
jiangk@sustech.edu.cn

教育经历

2011/4-2014/3 东京大学,农学生命科学研究科,应用生命化学专业,农学博士

2007/9-2010/6 四川农业大学,水稻研究所,生物化学与分子生物学专业,理学硕士

2003/9-2007/6 四川农业大学,农学院,生物技术专业,理学学士

 

工作经历

2018/9至今 南方科技大学,前沿与交叉科学研究院,研究助理教授

2018/4-2018/8 东京大学,农学与生命科学研究科,研究助理教授

2014/4-2018/3 东京大学,农学与生命科学研究科,博士后

 

研究领域:

从事植物激素信号转导和植物生长发育机制的研究。交叉性地运用经典遗传学、化学遗传学、有机化学、结构生物学、计算化学等多学科方法,湿实验和干实验(计算机辅助)结合的策略,从事小分子化合物的筛选和理性设计开发。借助小分子化合物进一步揭示信号转导和生长发育机制,推动基础科学研究。同时,紧密结合农业生产实践,面向实际需求开发植物生长调节剂。


研究方向:

1. 活性小分子化合物的高通量筛选及其作用机制研究;

2. 运用化学遗传学方法研究植物生长发育和基因转录后沉默机制;

3. 新型植物生长调节剂的开发及其在农业中的应用研究。


科研项目:

1. 国家自然科学基金青年基金,21907049,以赤霉素受体GID1为靶标的信号调节剂的开发,2020.01-2022.12,主持;

2. 广东省创新创业团队,2016ZT06S172,系统表观遗传学在作物改良中的应用,2017.07-2022.07,项目执行中,核心成员;

3.国家自然科学基金国际(地区)合作与交流项目,31911540070,运用化学生物学方法解析乙烯反应和RNA调控的分子机制,2019.04-2021.12,项目执行中,主要参与人;

4. 日本JST大型研究推进事业项目CREST,利用植物激素间互作与化学生物学调控技术提高植物生物产量,2012.10-2017/3,已结题,参与人。


代表文章:

1. Aizezi Y, Shu H, Zhang L, Zhao H, Peng Y, Lan H, Xie Y, Li J, Wang Y, Guo H#, and Jiang K#. Cytokinin regulates apical hook development via the coordinated actions of EIN3/EIL1 and PIF transcription factors in Arabidopsis. J. Exp. Bot. 2021, accepted.

2.Takahashi I, Jiang K, and Asami T. Counteractive effects of sugar and strigolactone on leaf senescence of rice in darkness. Agronomy. 2021, 11(6), 1044.

3. Watanabe D*, Takahashi I*, Jaroensanti-Tanaka N, Miyazaki S, Jiang K, Nakayasu M, Wada M, Asami T, Mizutani M, Okada K, Nakajima M. The apple gene responsible for columnar tree shape reduces the abundance of biologically active gibberellin. Plant J. 2021, 105:1026-1034.

4. Zhu Y, Li H, Su Q, Wen J, Wang Y, Song W, Xie Y, He W, Yang Z, Jiang K#, Guo H#. A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis. J Biol Chem. 2019, 294(52): 19923-19933.

5. Nakamura H*, Hirabayashi K*, Miyakawa T, Kikuzato K, Hu W, Xu Y, Jiang K, Takahashi I, Niiyama R, Dohmae N, Tanokura M, Asami T. #. Triazole ureas covalently bind to strigolactone receptor and antagonize strigolactone responses. Mol Plant. 2019, 12(1):44-58.

6. Takeuchi J*, Jiang K*, Hirabayashi K*, Imamura Y, Wu Y, Xu Y, Miyakawa T, Nakamura H, Tanokura M, Asami T#. Rationally Designed Strigolactone Analogs as Antagonists of the D14 Receptor. Plant Cell Physiol. 2018, 59(8):1545-1554.

7. Tian M*, Jiang K*, Takahashi I, Li G#. Strigolactone-induced senescence of a bamboo leaf in the dark is alleviated by exogenous sugar. J Pest Sci. 2018,43(3):173-179.

8. Jiang K and Asami T#. Chemical regulators of plant hormones and their applicationsin basic research and agriculture. Biosci Biotechnol Biochem. 2018, 82(8):1265-1300. (Front cover)

9. Jamil M, Kountche BA, Haider I, Guo X, Ntui VO, Jia KP, Ali S, Hameed US, Nakamura H, Lyu Y, Jiang K, Hirabayashi K, Tanokura M, Arold ST, Asami T, Al-Babili S#. Methyl phenlactonoates are efficient strigolactone analogs with simple structure. J Exp Bot. 2018, 69(9):2319-2331.

10. Ito S, Jiang K, and Asami T#. Chapter 7: Plant hormone cross-talk with a focus on strigolactone and its chemical dissection in rice” Springer book: Rice Genomics, Genetics and Breeding 2018

11.  Miyazaki S, Jiang K, Kobayashi M, Asami T, Nakajima M#. Helminthosporic acid functions as an agonist for gibberellin receptor. Biosci Biotechnol Biochem. 2017, 81(11):2152-2159.

12.  Jiang K*, Shimotakahara H*, Luo M*, Otani M, Nakamura H, Moselhy SS, Abualnaja KO, Al-Malki AL, Kumosani TA, Kitahata N, Nakano T, Nakajima M, Asami T#. Chemical screening and development of novel gibberellin mimics. Bioorg Med Chem Lett. 2017, 27(16):3678-3682.

13.  Jiang K*, Otani M*, Shimotakahara H, Yoon JM, Park SH, Miyaji T, Nakano T, Nakamura H, Nakajima M, Asami T#. Substituted Phthalimide AC94377 Is a Selective Agonist of the Gibberellin Receptor GID1. Plant Physiol. 2017, 173(1):825-835.

14.  Li G, Pan L, Jiang K, Takahashi I, Nakamura H, Xu Y, Asami T#, Shen R#. Strigolactone are involved in sugar signaling to modulate early seedling development in Arabidopsis. Plant Biotechnology. 2016, 33(2): 87-97. (front cover)

15.  Jiang K, Kurimoto T, Seo EK, Miyazaki S, Nakajima M, Nakamura H, Asami T. Development of Inhibitors of Salicylic Acid Signaling. J Agric Food Chem. 2015, 63(32):7124-33.

(*Co-first author, #Correspondi


专利:

1.   NRT1.7基因表达的抑制剂在制备衣霉素吸收抑制剂中的应用,2021.06.19,中国,202110678271.2

2.    PIFs的暗处稳定剂在促进双子叶植物顶端弯钩发育中的应用,2021.07.27,中国,202110581494.4

3.   小分子化合物在促进植物生长发育中的应用,2021.05.17,中国,202110040713.0

4.   一种土甘草提取物在制备果蔬保鲜剂中的应用,2020.12.31,中国,202011596465.X

5.   防治水稻稻瘟病和纹枯病的芽胞杆菌菌株, 2012.05.30, 中国,ZL201010028132.7

6.   防止水稻纹枯病和稻瘟病的链霉菌菌株,2012.04.25,中国,ZL201010028131.


社会服务:

2021.4至今,担任Journal of Pesticide Science(SCI收录 IF: 1.519)编委

2020.03起 担任Plant & Cell Physiology审稿人

病的芽孢杆菌菌株 专利号CN 101962623 B (2012)