BIO

Dr. Chunfu Yang is an Assistant Professor in the School of Public Health and Emergency Management, SUStech.  Dr. Yang received his Doctor of Philosophy degree in Microbiology from Institute Pasteur of Shanghai, Chinese Academy of Sciences in 2012. Dr. Yang started postdoctoral training at National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) in 2013 and then promoted as Staff Scientist at NIAID in 2017, where he studied immunopathogenesis of sexual transmitted disease due to Chlamydia infection. In 2021, Dr. Yang joined the faculty at School of Public Health and Emergency Management as an Assistant Professor. Dr. Yang has published many peer-reviewed manuscripts. His career aspirations are to understand immunopathogenesis of infectious diseases which would facilitate the development of new therapies for prevention of infectious diseases.  

EDUCATION

2007.09-2012.07   Institute Pasteur of Shanghai, Chinese Academy of Sciences, Ph.D.

2003.09-2006.07   Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Master

1999.09-2003.07   Veterinary Medicine, Shanxi Agricultural University, China, Bachelor

WORK EXPERIENCE

2021.12-now         Assistant Professor, School of Public Health and Emergency Management,

                               South University of Science and Technology of China

2017.06-2021.11   Staff Scientist, National Institute of Allergy and Infectious Diseases,

                               National Institutes of Health, USA

2015.06-2017.06   Research Fellow, National Institute of Allergy and Infectious Diseases,

                              National Institutes of Health, USA

2013.06-2015.06   Postdoctoral Fellow, National Institute of Allergy and Infectious Diseases,

                              National Institutes of Health, USA

2012.07-2013.05   Research Assistant, Institute Pasteur of Shanghai, Chinese Academy of

                              Sciences 

RESEARCH AREA

1.    Infectious Disease and Host-Pathogen Interaction

2.    Trained immunity in the immunopathogenesis of infectious disease

3.    Development of subunit vaccine against Chlamydia trachomatis

SELECTED PUBLICATIONS

1.   Yang C, Lei, L, Collins MJ, Briones M, Ma L, Sturdevant GL, Su H, Kashyap AK, Dorward D, Bock K, Moore I, Bonner C, Chen CY, Martens CA, Ricklefs S, Yamamoto M, Takeda K, Iwakura Y, McClarty G, Caldwell HD.  Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.  Nature Communications. (2021) 12:5454.

2.    Yang C, Kari L, Lei, L, Carlson JH, Ma L, Couch CE, Whitmire WM, Bock K, Moore I, Bonner C, McClarty G, Caldwell HD.  Chlamydia trachomatis Plasmid Gene Protein 3 Is Essential for the Establishment of Persistent Infection and Associated Immunopathology.  mBio. 2020 Aug 18; 11(4): e01902-20.

3.    Yang C, Briones M, Chiou J, Lei, L, Patton MJ, Ma L, McClarty G, Caldwell HD.  Chlamydia trachomatis Lipopolysaccharide Evades the Canonical and Noncanonical Inflammatory Pathways To Subvert Innate Immunity. mBio. 2019 Apr 23; 10(2): e00595-19.

4.    Yang C, Sturdevant GL, Whitmire WM, Caldwell HD.  Infection of Hysterectomized mice with Chlamydia muridarum and Chlamydia trachomatis. Infect Immun. 2017 May 1. doi: 10.1128

5.    Yang C, Starr T, Song L, Carlson JH, Sturdevant GL, Beare PA, Whitmire WM, Caldwell HD.  Chlamydial Exit from Host cells Is Plasmid Regulated. mBio. 2015 Nov 10; 6(6): e01648-15.

6.    Yang J*, Yang C*, Guo N, Zhu K, Kaiming L, Zhang N, Zhao H, Cui Y, Chen L, Wang H, Gu J, Ge B, Cheng-Feng Q, Leng Q. Type I interferons Triggered Through the TLR3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice. J. Virol. 2015 Nov;89(21):10860-7. (Co-first author).

7.    Zhu K, Yang J, Luo K, Yang C, Zhang N, Xu R, Chen J, Jin M, Xu B, Guo N, Wang J, Chen Z, Cui Y, Zhao H, Wang Y, Deng C, Bai L, Ge B, Qin CF, Shen H, Yang C*, Leng Q*.  TLR3 Signaling in Macrophages Is Indispensable for the Protective Immunity of Invariant Natural Killer T Cells against Enterovirus 71 Infection. PLoS Pathogens. 2015 Jan 23:11(1): e1004613. (Co-corresponding author).

8.   Yang C, Deng C, Wan J, Zhu L, Leng Q.  Neutralizing Antibody Response in the Patients with Hand, Foot and Mouth Disease to Enterovirus 71 and its Clinical Implications. Virol. J. 16; 8:306, 2011.