Self-introduction

Dr. Liu studied clinical medicine at Nan Chang University and then was trained in biochemistry and molecular biology at Peking University Health Science Center. He joined in Hongwei Wang’s group as a postdoc at Tsinghua University. Dr. Liu published several research papers in top journals including Cell, Nature Chemical Biology, etc.

Research Interests：

We use the Cryo-EM, biochemistry, molecular biology and cell biology to study the mechanism of macromolecular complexes. Our research interests include: 1) Studies on the mechanism underlying ribonucleic protein complexes. 2) Studies on the mechanism underlying G protein coupled receptors.

Professional Experience：

◆ 2019-Present: assistant professor, Department of Biology, SUSTech, Shenzhen.

◆ 2015-2019: Postdoctoral Fellow, School of Life Sciences, Tsinghua University.

Educational Background：

◆ 2009-2015 Ph.D. Department of Biochemistry and Molecular Biology, Peking University Health Sciences Center.

◆ 2004-2009 Bachelor degree of medicine, School of Medicine, Nan Chang University

Selected Publication：

1.Mu, J.Q.#, Wu, C.#, Xu, K.M, Liu, X.G., Fu, Y.J. Zhang, Z., Yu J.W., Xue, C.Y., Wang, Z., Chen, X.M., Chen, Y.H.,Ou, G.S.*, Liu, Z.M.*. (2025). Conformational Reorganization and Phase Separation Drive Hyper-Editing of ADR-2-ADBP-1 Complex, Nucleic Acids Research, (Accepted, 最后共同通讯作者). 实验室2021级博士生穆建强、2020级硕士吴藏为本文共同第一作者。

2.Yang J#, Wang T.Y.#, Huang Y#, Li X.Z, Long Z.Y., Zhang S.Q., Zhang L.L., Liu Z.K., Sun H.B., Zhang M.J., Yin H, Liu, Z.M.*, Heng Zhang*. (2025). Structural insights into the target recognition mechanism of the compact Cas9d. Nature Communications, (Accepted,共同通讯作者)。实验室2020级博士生黄颖为本文共同第一作者。

3.Liu J#, Wu C#, Liu Y.Y, Chen Q.G., Ding Y.Z., Lin Z.Q., Pan L.F., Xiao K, Li J.C.*, Liu, Z.M.*, Liu W*. (2025). Structural insights into the Dual Ca2+-Sensor-Mediated Activation of the PPEF Phosphatase Family, Nature Communications, (Accepted,共同通讯作者)。实验室2020级硕士吴藏为本文共同第一作者。

2024年

1. Chenyang Xue, Junshan Tian, Yanhong Chen, Zhongmin Liu*; Structural insights into human ELAC2 as a tRNA 3' processing enzyme, Nucleic Acids Research,  2024,  (研究性论文) （唯一通讯作者，2022级博士生薛晨阳为唯一第一作者）。

2. Kun Liu#, Cang Wu#, Mingyue Zhu#, Junnv Xu#, Bo Lin, Haifeng Lin, Zhongmin Liu* & Mengsen Li*，Structural characteristics of alpha- fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites, Communications Biology, 2024, 7:505, (研究性论文) （共同通讯作者）实验室访问学生刘坤博士、2020级硕士生吴藏为本文共同第一作者。

3. Ying Huang#, Chenyang Xue#, Ruiqian Bu#, Cang Wu#, Jiachen Li, Jinqiu Zhang, Jinyu Chen, Zhaoying Shi, Yonglong Chen, Yong Wang*, Zhongmin Liu*; Transport mechanism and peptide inhibitor of the autoinhibited ABC transporter, hMRP5, Nature Communications,2024, (研究性论文, Highlighted by Nature Communications Editor-https://www.nature.com/ncomms/editorshighlights) （最后共同通讯作者）实验室2020级博士生黄颖、2022级博士生薛晨阳、2019级博士生卜瑞倩、2020级硕士吴藏为本文共同第一作者。

2023年

1. Lulu Guo#; Yumu Zhang#; Guoxing Fang#; Lu Tie#; Yuming Zhuang#; Chenyang Xue#; Qi Liu; Minghui Zhang; Kongkai Zhu; Chongzhao You; Peiyu Xu; Qingning Yuan; Chao Zhang; Lei Liu; Naikang Rong; Shengxuan Peng; Yuan Liu; Chuanzheng Wang; Xin Luo; Zongyao Lv; Dongwei Kang; Xiao Yu; Cheng Zhang; Yi Jiang; Xinzhong Dong*; Jiuyao Zhou*; Zhongmin Liu*; Fan Yang*; Eric Xu*; Jin-Peng Sun*; Ligand recognition and G protein coupling of the human itch receptor MRGPRX1, Nature Communications, 2023, 14(5004). (研究性论文) （共同通讯作者）实验室2022级博士生薛晨阳为本文共同第一作者。

2. Shen-Ming Huang#; Meng-Yao Xiong#; Lei Liu#; Jianqiang Mu#; Ming-Wei Wang#; Ying-Li Jia#; Kui Cai#; Lu Tie; Chao Zhang; Sheng Cao; Xin Wen; Xiaoyan Zhang*; Zhongmin Liu*; Bao-Xue Yang*; Yang Du*; Jin-Peng Sun*; Single hormone or synthetic agonist induce Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths, proceedings of the national academy of sciences of the united states of America （PNAS）, 2023, 120(30): e2216329120. (研究性论文)（共同通讯作者）实验室2021级博士生穆建强为本文共同第一作者。

3. Mengqi Wu#; Cang Wu#; Tiefeng Song#; Kewu Pan; Yong Wang*; Zhongmin Liu*; Structure and transport mechanism of the human calcium pump SPCA1, Cell Research, 2023, 33(7): 533-545. (研究性论文) （共同通讯作者）实验室2020级硕士武梦琪、吴藏为本文共同第一作者。

4. Huang Ying#; Xue Chenyang#; Wang Liangdong; Bu Ruiqian; Mu Jianqiang; Wang Yong*; Liu Zhongmin*; Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4., Communications Biology, 2023, 6(1). (研究性论文) （共同通讯作者）实验室2020级博士生黄颖、2022级博士生薛晨阳为本文共同第一作者。

5. Mu Jianqiang#; Xue Chenyang#; Fu Lei#; Yu Zongjun; Nie Minhan; Wu Mengqi; Chen Xinmeng; Liu Kun; Bu Ruiqian; Huang Ying; Yang Baisheng; Han Jianming; Jiang Qianru; Chan Kevin C; Zhou Ruhong; Li Huilin; Huang Ancheng; Wang Yong*; Liu Zhongmin*; Conformational cycle of human polyamine transporter ATP13A2., Nature Communications, 2023, 14(1). (研究性论文) （共同通讯作者）实验室2021级博士生穆建强、2022级博士生薛晨阳为本文共同第一作者。

6. Zheng, Liming; Liu, Nan*; Gao, Xiaoyin; Zhu, Wenqing; Liu, Kun; Wu, Cang; Yan, Rui; Zhang, Jincan; Gao, Xin; Yao, Yating; Deng, Bing; Xu, Jie; Lu, Ye; Liu, Zhongmin; Li, Mengsen; Wei, Xiaoding*; Wang, Hong-Wei*; Peng, Hailin*; Uniform thin ice on ultraflat graphene for high-resolution cryo-EM, Nature Methods, 2023, 20(1): 123-+. (研究性论文) 实验室访问学生刘坤、2020级硕士吴藏参与本文工作。

2022年

1. Lin, Hui; Xiao, Peng; Bu, Rui-Qian; Guo, Shengchao; Yang, Zhao; Yuan, Daopeng; Zhu, Zhong-Liang; Zhang, Chuan-Xin; He, Qing-Tao; Zhang, Chao; Ping, Yu-Qi; Zhao, Ru-Jia; Ma, Chuan-Shun; Liu, Chang-Hao; Zhang, Xiao-Ning; Jiang, Dan; Huang, Shaohui; Xi, Yue-Tong; Zhang, Dao-Lai; Xue, Chen-Yang; Yang, Bai-Sheng; Li, Jian-Yuan; Lin, Hao-Cheng; Zeng, Xu-Hui; Zhao, Han; Xu, Wen-Ming; Yi, Fan*; Liu, Zhongmin*; Sun, Jin-Peng*; Yu, Xiao*; Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms, Nature Chemical Biology, 2022, 18(11): 1196-+. (研究性论文) （共同通讯作者）实验室2019级博士生卜瑞倩为本文共同第一作者。

2020年

1. Yuan, Daopeng#; Liu, Zhongmin#; Kaindl, Jonas; Maeda, Shoji; Zhao, Jiawei; Sun, Xiaoou; Xu, Jun; Gmeiner, Peter*; Wang, Hong-Wei*; Kobilka, Brian K.*; Activation of the alpha(2B) adrenoceptor by the sedative sympatholytic dexmedetomidine, Nature Chemical Biology, 2020, 16(5): 507-+. (研究性论文) （共同第一作者）

2018年

1. Liu, Zhongmin#; Wang, Jia#; Cheng, Hang#; Ke, Xin#; Sun, Lei; Zhang, Qiangfeng Cliff; Wang, Hong-Wei*; Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate, Cell, 2018, 173(5): 1191-+. (期研究性论文) （共同第一作者）

2017年

1. Guan Zhe; Cai Tiantian; Liu Zhongmin; Dou Yunfeng; Hu Xuesong; Zhang Peng; Sun Xin; Li Hongwei; Kuang Yao; Zhai Qiran; Ruan Hao; Li Xuanxuan; Li Zeyang; Zhu Qihui; Mai Jingeng; Wang Qining; Lai Luhua; Ji Jianguo; Liu Haiguang; Xia Bin; Jiang Taijiao; Luo Shu Jin; Wang Hong Wei; Xie Can*; Origin of the Reflectin Gene and Hierarchical Assembly of Its Protein, Current Biology, 2017, 27(18): 2833-+. (研究性论文)

2016年

1. Qin, Siying#; Yin, Hang#; Yang, Celi; Dou, Yunfeng; Liu, Zhongmin; Zhang, Peng; Yu, He; Huang, Yulong; Feng, Jing; Hao, Junfeng; Hao, Jia; Deng, Lizong; Yan, Xiyun; Dong, Xiaoli; Zhao, Zhongxian; Jiang, Taijiao; Wang, Hong-Wei; Luo, Shu-Jin; Xie, Can*; A magnetic protein biocompass, Nature Materials, 2016, 15(2): 217. (研究性论文)

2015年

1. Liu Zhongmin#; Wang Jia; Li Gang*; Wang Hong Wei*; Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain, Protein & Cell, 2015, 6(3): 185-193. (研究性论文) （第一作者）

2012年

1. Li Chaoying#; Wang Shanshan; Jiang Wei; Li Hui; Liu Zhongmin; Zhang Chao; McNutt Michael A; Li Gang*; Impact of intracellular alpha fetoprotein on retinoic acid receptors-mediated expression of GADD153 in human hepatoma cell lines, International Journal of Cancer, 2012, 130(4): 754-764. (研究性论文)

1. Wang Shanshan; Jiang Wei; Chen Xiangmei; Zhang Chao; Li Hui; Hou Wenting; Liu Zhongmin; McNutt Michael A; Lu Fengmin*; Li Gang*; Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma, Journal of Hepatology, 2012, 57(2): 322-329. (研究性论文)

2011年

1. Li, Mengsen; Li, Hui; Li, Chaoying; Wang, Shanshan; Jiang, Wei; Liu, Zhongmin; Zhou, Sheng; Liu, Xinhua; McNutt, Michael A.; Li, Gang*; Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines, International Journal of Cancer, 2011, 128(3): 524-532. (研究性论文)