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Xiaoling YU
Research Associate Professor


Dr. Xiaoling Yu is currently the research associate professor at school of life sciences of Southern University of Science and Technology(SUSTech). Dr. Yu received her Ph.D. degree from the Fourth Military Medical University. She then did her postdoctoral research in the Department of Cell Biology at Harvard Medical School. Her work focuses on using cryo-EM and biochemical approaches to understand the structural and dynamic mechanisms of biological macromolecules.

Research Interests:

◆ Structure and dynamic mechanisms of macromolecular machines.

◆ Bottom-up membrane proteome and systems structural proteomics.

Professional Experience:

◆ 2023-present   Research Associate Professor, SUSTech, China

◆ 2022-2023  Associate Investigator, Shenzhen Bay Laboratory, China

◆ 2018-2022  Research Assistant Professor, SUSTech, China

◆ 2012-2015  Postdoctoral Fellow, Harvard Medical School, USA

◆ 2010-2017  Associate Professor, Fourth Military Medical University, China

Educational Background:

◆ 2005-2008  Ph.D. in Cell Biology, Fourth Military Medical University, China

◆ 2002-2005  Master in Cell Biology, Fourth Military Medical University, China

◆ 1998-2002  Bachelor in Biotechnology, Fourth Military Medical University, China

Honors & Awards:

◆ 2018  Shenzhen High-Caliber Local Leading Personnel 

◆ 2014  Higher Education Research and Technology Invention Award, Minister of

             Education of the People's Republic of China

◆ 2008  Immunology Young Scholar Prize, Chinese Society for Immunology 

◆ 2007  Outstanding Paper Award, Chinese Society for Cell Biology

Selected Publication:

◆(* Corresponding author;# Co-first author)

1. Guo N#, Ye S#, Zhang K#, Yu X#, Cui H, Yang X, Lin P, Lv M, Miao J, Zhang Y, Han Q, Zhang R, Chen Z, Zhu P.  A critical epitope in CD147 facilitates memory CD4+ T-cell hyper-activation in rheumatoid arthritis. Cellular & Molecular Immunology. 2019;16:568–79.

2. Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM. Architecture of the human PI4KIIIα lipid kinase complex. Proc Natl Acad Sci U S A. 2017;114(52): 13720-5.

3. Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC. Molecular architecture of the αβ T cell receptor-CD3 complex. Proc Natl Acad Sci U S A. 2014;111(49):17576-81.  

4. Yu XL, Hu T, Du JM, Yang XM, Zhang J, Yang B, Shen X, Zhang Z, Zhong WD, Wen N, Ding JP, Jiang H, Zhu P, Chen ZN. Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem. 2008;283(26):18056-65.

5. Yu XL, Jiang JL, Li L, Feng Q, Xu J, Chen ZN. The glycosylation characteristic of hepatoma-associated antigen HAb18G/CD147 in human hepatoma cells. Int J Biochem Cell Biol. 2006; 38(11):1939-45.

6. Tang J#, Guo YS#, Yu XL#, Huang W, Zheng M, Zhou YH, Nan G, Wang JC, Yang HJ, Yu JM, Jiang JL, Chen ZN. CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma. Oncotarget. 2015; 6 (33):34831-45.

7. Cui HY, Guo T, Wang SJ, Zhao P, Dong ZS, Zhang Y, Jiang JL, Chen ZN, Yu XL*. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochem Biophys Res Commun. 2012;419(3):517-22.  

8. Tang J, Guo YS, Zhang Y, Yu XL, Li L, Huang W, Li Y, Chen B, Jiang JL, Chen ZN. CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma. Cell Death Differ, 2012;19(11):1779-90.