SELF-INTRODUCTION：

Jia, Ning is an associate professorin in School of Medicine, SUSTech. Ning got her PhD degree in biochemistry and molecular biology at University of Science and Technology of China in 2016. Then she started her postdoctoral training in Dinshaw J. Patel lab at Memorial Sloan Kettering Cancer Center. Ning joined SUSTech on May, 2021. Ning has focused on elucidating the mechanisms underlying the mysteries of the arms race between microorganisms and their host immune systems. In the past few years, Ning has published 14 research papers as first author or corresponding author (Nature Chemical Biology2023；Molecular cell 2023；Science, 2020; Nature Reviews Molecular Cell Biology, 2021；Molecular Cell, 2019a, 2019b, 2019c; Nature Communications, 2022; Cell Research, 2020，2022; PNAS, 2019; EMBO reports, 2016). The paper Nature Communications, 2022 is recommended by Faculty Opinions; Besides, as first author and co-corresponding author, Ning has been invited to write a review published on Nature Reviews Molecular Cell Biology. In recognition of her scientific excellence, Ning became the sole recipient of 2020 Blavatnik Regional Awards for Young Scientists in Chemistry and was elected as MIT Technology Review Innovators Under 35 Asia Pacific 2022. She joined the Editorial Board of the Journal of Biological Chemistry (the JBC) since July 1, 2024.

EDUCATION:

2006-2010 Ocean University of China, BS.

2010-2016 University of Science and Technology of China, PhD. Advisor: Zhou, Cong-Zhao/ Chen, Yuxing

WOKRING EXPERIENCE:

2022.06-present, Associate Professor，School of Medicine, Southern University of Science and Technology（SUSTech）

2021.05-2022.05, Assistant Professor，School of Medicine, Southern University of Science and Technology（SUSTech）

2017-2021 Research Fellow, Memorial Sloan Kettering Cancer Center, New York, USA

HONORS AND AWARDS:

2024     Editorial Board member of the Journal of Biological Chemistry (the JBC)

2022      MIT Technology Review Innovators Under 35 Asia Pacific 2022. 

2020      Blavatnik Regional Awards for Young Scientists, Winner in Chemistry.

2016      Caisi-Zebrafish Research Award

2010      Outstanding Graduate in Shandong Province

2007,2009 National Scholarship  

RESEARCH INTERESTS:

1）Elucidating the mechanism of the arm race between microorganisms and their host immune systems, particularly the prokaryotic immune systems that defend against the invading phages and plasmids.

2）Developing biotechnological tools, including gene editing tools based on CRISPR-Cas systems, to advance our ability to understand and manipulate biological systems.

MANUSCRIPT REVIEWER AND EDITOR：

Nature Communications, Nucleic Acids Research Reviewer

PUBLICATIONS：

（# co-first author;   *co-corresponding   author ）

（#第一作者;   *通讯作者 ）

1. Zhang, J.T.#, Liu, X.Y.#, Li, Z.L.#, Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797. 10.1038/s41467-024-47177-9.

2. Zhang, J.T.#, Wei, X. Y. #, Cui, N., Tian, R., Jia, N.* (2023).Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology. 10.1038/s41589-023-01479-z.

3. Cui, N.#, Zhang, J.T.#, Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.

4. Duan, Z.#, Zhang, X.#, Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N.*, and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.

5. Cui, N.#, Zhang, J.T.#, Li, Z., Liu, X.Y.,Wang, C., Huang, H.*, and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549. 

6. Patel, D.J.*, Yu, Y., and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.  

7. Jia, N.* & Patel, D.J.* Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877 (2022). 

8. Jia, N.*, Patel. D. J.*. (2021) Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.

9. Meeske A. J.#, Jia, N.#, Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J.*, Marraffini L. A.*. (2020) A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.

10. Jia, N.*, Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J.* (2020) Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.

11. Jia, N.*, Jones, R., Yang, G., Ouerfelli, O., Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.

12. Jia, N.*, Jones, R., Sukenick, G., Patel, D.J.* (2019) Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936. 

13. Jia, N.*, Mo, C.Y., Wang, C., Eng, E.T., Marraffini, L.A., Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265. 

14. Jia, N.#, Unciuleac, M.#, Xue C., Greene E.C., Patel, D.J.*, Shuman, S.* (2019) Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516. 

15. Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H., Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.

16. Chen, L.L., Xie, J., Cao, D.D., Jia, N., Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.

17. Zhou, K., Jia, N., Hu, C., Jiang, Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229. 

18. Song, N., Jia, N., Yanagimoto, T., Lin, L., Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.

19. He, Y.X., Zhang, N.N., Li, W.F., Jia, N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207.