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贾宁
长聘副教授
0755-88010071
jian@sustech.edu.cn
个人主页

个人简介：

贾宁，医学院长聘副教授（研究员），博士生导师，国家级青年人才。2016年于中国科学技术大学生命学院获得博士学位，随后在美国纪念斯隆凯特琳癌症中心从事博士后研究。2021年5月加入南方科技大学医学院。长期聚焦于细菌免疫与噬菌体互作机制研究，近年来以通讯作者身份（含共同）发表论文17篇 (Science 2025a, 2025b；Cell Host & Microbe 2026；Nature Chemical Biology 2024；Molecular Cell 2023，2019a, 2019b, 2019c；Nature Reviews Molecular Cell Biology, 2021等)。其中多项工作分别被世界学术组织“Faculty Opinions（原F1000Prime）”推荐，被Science、Nature Reviews Microbiology、Cell Research 等杂志作为研究亮点报道。担任Nature、Science、Nature Microbiology等杂志审稿人。多次受邀在德国、新西兰、法国等举办的CRISPR国际年度会议和EMBO workshop（巴斯德研究所）作报告。获得美国布拉瓦尼克区域青年科学家化学奖（2020），入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单（2022），首届何享健青年科学家项目（2025），国家基金委青年科学基金项目A类（2026）和科学探索奖（2026）。


教育背景：

2006-2010 中国海洋大学， 海洋生物资源与环境，学士

2010-2016 中国科学技术大学，生物化学与分子生物学，博士 

 

工作经历：

2025.11-至今     南方科技大学医学院，长聘副教授

2022.06-2025. 11 南方科技大学医学院，副教授

2021.05-2022.05  南方科技大学医学院，助理教授

2017-2021       美国纪念斯隆凯特琳癌症中心，博士后 

 

获奖情况及荣誉：

2026    科学探索奖

2026    国家基金委青年科学基金项目A类

2025    广东省科学技术奖-青年科技创新奖

2025    深圳市青年科学基金项目A类

2025    首届何享健青年科学家项目

2025    南方科技大学年度青年教授奖、校长青年科研奖、方铿奖教金

2022     入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单

2020     美国布拉瓦尼克区域青年科学家化学奖 (2020 Blavatnik Regional Awards for Young Scientists Winner in Chemistry)

2016      蔡司-斑马鱼科学研究奖

2010      山东省优秀毕业生


研究兴趣：

1）聚焦细菌抗病毒（噬菌体）免疫机制及噬菌体反防御机制。

2）基于细菌与噬菌体互作机制，开发新型抗菌策略和相关分子工具。


学术任职：

· Journal of Biological Chemistry (JBC)和Engineering Microbiology 编委，mLife 、hLife、iMeta 和Oral Science and Homeostatic Medicine期刊的青年编委

· Nature, Science, Cell Host& Microbe, Nature Microbiology, Molecular Cell, Nature Chemical Biology 等期刊审稿人

 

发表论文：

（#第一作者;   *通讯作者 ）

  1. Song, X. Y.#; Xia, Y.#; Zhang, J. T.#; Liu, Y. J.; Qi, H.; Wei, X. Y.; Hu, H.;Xia, Y.; Liu, X.; Ma, Y.F.; Jia, N.* (2025). Bacterial reverse transcriptase synthesizes long polyA-rich cDNA for anti-phage defense, Science, 2025 May 1:eads4639. doi: 10.1126/science.ads4639.

  2. Hayes, V. M. #; Zhang, J. T.#; Katz, M. A.; Li, Y.; Kocsis, B.; Jia, N.*; Meeske, A. J.* (2025). RNA-mediated CRISPR-Cas13 inhibition via crRNA structural mimicry. Science, 388(6745): 387-391

  3. Xia, Y.; Qi, H.; Wei, X. Y.; Zhang, J. T.; Hu W.; Liu, Y. J., Song, X. Y.; Liu, X., Wang, C.; Jia, N.* (2026). Dual sensing activates antiviral reverse transcriptase for membrane targeting. Cell Host & Microbe, 2026 Sep 2:S1931-3128(26)00326-4.

  4. Zhang, J.T.#; Wei, X.Y.#; Cui, N.; Tian, R. & Jia, N. * (2024). Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology 20, 503-511 .

  5. Cui, N.#; Zhang, J.T.#; Li, Y.; Liu, Y.; Liu, X.Y.; Wang, C.; Huang, H.* and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.

  6. Ji, C.G.#, Li, Z.#, Wei, X.Y., Li, Y., Zhang, J.T., Liu, X.*, and Jia, N.* (2026). Mechanistic insights into activation of bacterial Retron-Eco8 immunity by phage protein SSB. Nature communications 17. 10.1038/s41467-026-74106-9.

  7. Cui, N.#; Zhang, J.T.#; Li, Z.; Wei, X.Y.; Wang, J. and Jia, N.* (2024). Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system. Nature Communications 15, 8610 .

  8. Zhang, J.T.#; Liu, X.Y.#; Li, Z.L.#; Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H. and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797.

  9. Duan,Z.#,Zhang, X.#, Zhang, J.T.#, Ji,X.#, Liu,R., Chen, Y., Li, S., Jia, N. Gao.H.. Xin, Y., Jia, N.* and Zhu, J.K.* (2024). Structure and genome editing activity of the novel CRISPR-Cas12ol effector. Cell Research 35, 145-148

  10. Duan, Z.#; Zhang, X.#; Zhang, J.T.; Li, S; Liu, R.; Sun, J.; Zhao, Q.; Jia, N.; Jia, N.* and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.

  11. Cui, N.#; Zhang, J.T.#; Li, Z.; Liu, X.Y.;Wang, C.; Huang, H.* and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549. 

  12. Patel, D.J.*; Yu, Y. and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.  

  13. Jia, N.* & Patel, D.J.* (2022). Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877. 

  14. Jia, N.*; Patel. D. J.* (2021). Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.

  15. Meeske A. J.#; Jia, N.#; Cassel A.K.; Kozlova A.; Liao J.; Wiedmann M.; Patel D. J.*; Marraffini L. A.* (2020). A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.

  16. Jia, N.*; Xie, W.; De La Cruz, J.M.; Eng, E.T.; Patel, D.J.* (2020). Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.

  17. Jia, N.*; Jones, R.; Yang, G.; Ouerfelli, O.; Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.

  18. Jia, N.*; Jones, R.; Sukenick, G.; Patel, D.J.* (2019). Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936. 

  19. Jia, N.*; Mo, C.Y.;Wang, C.; Eng, E.T.; Marraffini, L.A.; Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265. 

  20. Jia, N.#; Unciuleac, M.#; Xue C.; Greene E.C.; Patel, D.J.*; Shuman, S.* (2019). Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516. 

  21. Jia, N.; Liu, N.; Cheng, W.; Jiang, Y.L.; Sun, H.; Chen, L.L.; Peng, J.; Zhang, Y.; Ding, Y.H.; Zhang, Z.H.; et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.

  22. Chen, L.L.; Xie, J.; Cao, D.D.; Jia, N.; Li, Y.J.; Sun, H.; Li, W.F.; Hu, B.; Chen, Y.; Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.

  23. Zhou, K.; Jia, N.; Hu, C.; Jiang, Y.L.; Yang, J.P.; Chen, Y.; Li, S.; Li, W.F.; Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229. 

  24. Song, N.; Jia, N.; Yanagimoto, T.; Lin, L.; Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.

  25.  He, Y.X.; Zhang, N.N.; Li, W.F.; Jia, N.; Chen, B.Y.; Zhou, K.; Zhang, J.; Chen, Y.; Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the            assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207