个人简介：

贾宁，医学院副教授，博士生导师。入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单（2022），美国布拉瓦尼克区域青年科学家化学奖获得者（2020）。加入Journal of Biological Chemistry (JBC)期刊作为Editorial Board member (2024)。2016年于中国科学技术大学生命学院获得博士学位，师从周丛照/陈宇星教授。2017-2021年在美国纪念斯隆凯特琳癌症中心从事博士后研究，导师是美国两院院士Dinshaw J. Patel教授。2021年5月加入南方科技大学医学院。主要研究兴趣为微生物与宿主免疫系统相互作用的分子机制。近年来以第一作者身以及通讯作者身份（含共同）发表论文16篇 (Nature Chemical Biology 2024；Molecular Cell 2023，2019a, 2019b, 2019c；Nature Communications, 2024a,b, 2022; Science, 2020; Nature Reviews Molecular Cell Biology, 2021； Cell Research, 2024, 2022, 2020; PNAS, 2019等)。其中，13篇为通讯作者。Nature Communications, 2022 被世界学术组织“Faculty Opinions (原F1000Prime)”推荐；作为第一作者兼共同通讯作者发表综述文章 (Nature Reviews Molecular Cell biology, 2021)。主持国自然面上、省市基金多项。担任Nature、Nature Catalysis、Nature Chemical Biology、Nature Communications 等杂志审稿人。

教育背景：

2006-2010 中国海洋大学，学士

2010-2016 中国科学技术大学，博士 （导师：周丛照、陈宇星教授）

工作经历：

2022.06-至今  南方科技大学医学院，副教授

2021.05-2022.05 南方科技大学医学院，助理教授

2017-2021 美国纪念斯隆凯特琳癌症中心，博士后 （导师：Dinshaw J. Patel）

获奖情况及荣誉：

2024     入选Journal of Biological Chemistry (JBC)期刊的Editorial Board member

2022     入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单（2022）

2020      美国布拉瓦尼克区域青年科学家化学奖 (2020 Blavatnik Regional Awards for Young Scientists Winner in Chemistry)

2016      蔡司-斑马鱼科学研究奖

2010      山东省优秀毕业生

2007，2009 国家奖学金

研究兴趣：

1）课题组通过结合生物化学、分子生物学、微生物学及结构生物学等手段，探究微生物与宿主免疫系统相互作用的分子机制，尤其关注细菌和古菌免疫系统（如CRISPR-Cas适应性免疫系统）抵御噬菌体和质粒入侵的分子机制。

2）基于微生物与宿主免疫系统相互作用分子机制的理解，开发相应的生物技术工具（如CRISPR-Cas基因编辑工具）。

学术任职：

Journal of Biological Chemistry (JBC)期刊的Editorial Board member

纽约科学学会（The New York Academy of Sciences）会员

发表论文：

（#第一作者;   *通讯作者 ）

1. Zhang, J.T., Wei, X.Y., Cui, N., Tian, R. & Jia, N. * （2024）Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology 20, 503-511 .

2. Cui, N. et al.(2024）Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system. Nature Communications 15, 8610 .

3. Duan, Z. et al. （2024）Structure and genome editing activity of the novel CRISPR-Cas12o1 effector. Cell Research . doi: 10.1038/s41422-024-01050-y.

4. Zhang, J.T.#, Liu, X.Y.#, Li, Z.L.#, Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797. 10.1038/s41467-024-47177-9.

5. Zhang, J.T.#, Wei, X. Y. #, Cui, N., Tian, R., Jia, N.* (2023).Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology. 10.1038/s41589-023-01479-z.

6. Cui, N.#, Zhang, J.T.#, Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.

7. Duan, Z.#, Zhang, X.#, Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N.*, and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.

8. Cui, N.#, Zhang, J.T.#, Li, Z., Liu, X.Y.,Wang, C., Huang, H.*, and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549. 

9. Patel, D.J.*, Yu, Y., and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.  

10. Jia, N.* & Patel, D.J.* Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877 (2022). 

11. Jia, N.*, Patel. D. J.*. (2021) Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.

12. Meeske A. J.#, Jia, N.#, Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J.*, Marraffini L. A.*. (2020) A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.

13. Jia, N.*, Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J.* (2020) Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.

14. Jia, N.*, Jones, R., Yang, G., Ouerfelli, O., Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.

15. Jia, N.*, Jones, R., Sukenick, G., Patel, D.J.* (2019) Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936. 

16. Jia, N.*, Mo, C.Y., Wang, C., Eng, E.T., Marraffini, L.A., Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265. 

17. Jia, N.#, Unciuleac, M.#, Xue C., Greene E.C., Patel, D.J.*, Shuman, S.* (2019) Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516. 

18. Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H., Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.

19. Chen, L.L., Xie, J., Cao, D.D., Jia, N., Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.

20. Zhou, K., Jia, N., Hu, C., Jiang, Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229. 

21. Song, N., Jia, N., Yanagimoto, T., Lin, L., Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.

22. He, Y.X., Zhang, N.N., Li, W.F., Jia, N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207.

已申请专利:

贾宁，黄鸿达，崔宁，张峻涛， 一种IV型CRISPR-Csf复合物、载体系统，202211033009.3， 2022-08-26