Faculty
Personal Profile
Wang Lin, male, MD, Professor of Medicine, Southern University of Science and Technology School of Medicine, Associate professor, chief physician, researcher, doctoral supervisor, Shenzhen "Pengcheng Peacock Program" special position B file, Washington University School of Medicine, Spine Surgery Center in St. Louis Research fellow. Presided over 3 projects of National Natural Science Foundation and 1 project of Guangdong Natural Science Foundation; Published 31 SCI papers and 42 core journal papers; It has been authorized 10 national invention patents and 4 utility model patents. It has trained 6 doctoral students and 6 master students. He is a well-known young and middle-aged expert in spinal surgery and spinal malformation in China. He has completed the world's first mixed reality (MR) guided spinal surgery (2019), the first O-arm assisted Tianguet robotic spinal surgery (2019), and the first Mazor Renaissance robotic cervical spine surgery (2014). He is currently a member of the 20th Council of Guangdong Medical Association. Member of the fourth Council of Guangdong Rehabilitation Medical Association; The first Executive Director of Cervical Spondylosis Branch of Guangdong Rehabilitation Medical Association; Member of the third Council of Spinal Cord Branch of Guangdong Rehabilitation Medical Association; The first Vice Chairman of the Spine and Joint Health Branch of Guangdong Health Association; Chairman of the 2nd Board of Intelligent and Digital Surgery Professional Committee of Shenzhen Medical Doctors Association; Standing Director of the second Council of Orthopedic Surgeons Branch of Shenzhen Medical Association; Member of Digital Orthopaedics Group, Chinese Medical Association Society of Medical Engineering; Member of Information Construction Committee of China Orthopaedic College; Director General, Intelligent and Digital Surgery Branch, Chinese Society of Gerontology; Member of the second Council of Chinese Geriatrics Society; Standing Member of the first Committee of Medical Artificial Intelligence Professional Committee of Chinese Hospital Association; Member of the International Education Working Group of the 3rd Orthopaedic Spine Branch of Chinese Medical Education Association.
Research
1. The core mechanism of the steady state imbalance of glycolipid metabolism in the development of osteopathy
2. Microenvironment and biological behavior of the surface interface of bone implanted materials
3. Bone tissue engineering and regenerative medicine
Teaching
Introduction of Bone & Joint Disorders
Education
1995-2000 Fourth Military Medical University, PLA, Bachelor of Medicine
2002-2005 PLA Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Master of Orthopaedics
2005-2008 PLA Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, MD&Ph.D
2012.1-8 Spinal Surgery Center, Washington University in St. Louis, School of Medicine, Research Fellow
Academic Appointments
2000-2008, Residency/Teaching Assistant, Department of Orthopaedic Surgery, Xijing Hospital，Fourth Military Medical University
2008-2016, Attending Surgeon/Instructor, Department of Orthopaedic Surgery, Xijing Hospital，Fourth Military Medical University
2016-2018.7, Attending Surgeon/Associate Professor, Department of Orthopaedic Surgery, the First Affiliated Hospital of Xi’an Jiaotong University
2018.7-2024.4, Attending Spinal Surgeon, Southern University of Science and Technology Hospital
2018.7-Now, Attending Associate Professor, School of Medicine, Southern University of Science and Technology
Peer-reviewed Publications
[1]Z. Wu, Q. Hou, H. Chi, J. Liu, Y. Mei, T. Chen, K. Yang, J. Zheng, J. Xu, F. Wei, and L. Wang, Single-cell RNA sequencing reveals a distinct profile of bone immune microenvironment and decreased osteoclast differentiation in type 2 diabetic mice. GENES & DISEASES 11 (2024).
[2] T. Chen, Z. Wu, Q. Hou, Y. Mei, K. Yang, J. Xu, and L. Wang, The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair. International Journal of Nanomedicine 19 (2024) 2709-2732.
[3] Z. Wu, Q. Hou, T. Chen, X. Jiang, L. Wang, J. Xu, and L. Wang, ROS-reactive PMS/PC drug delivery system improves new bone formation under diabetic conditions by promoting angiogenesis-osteogenesis coupling via down-regulating NOX2-ROS signalling axis. Biomaterials 293 (2023).
[4] L. Wang, M. Shen, Q. Hou, Z. Wu, J. Xu, and L. Wang, 3D printing of reduced glutathione grafted gelatine methacrylate hydrogel scaffold promotes diabetic bone regeneration by activating PI3K/Akt signaling pathway. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 222 (2022) 1175-1191.
[5] Z. Wang, T. Chen, Z. Wu, X. Jiang, Q. Hou, S. Miao, R. Xia, L. Wang, The dual-effects of PLGA@MT electrospun nanofiber coatings on promoting osteogenesis at the titanium-bone interface under diabetic conditions, Journal of Materials Chemistry B 10(21) (2022) 4020-4030.
[6] X.Y. Ma, T.C. Ma, Y.F. Feng, G. Xiang, W. Lei, D.P. Zhou, H.L. Yu, L.B. Xiang, L. Wang, Promotion of osteointegration under diabetic conditions by a silk fibroin coating on 3D-printed porous titanium implants via a ROS-mediated NF-kappaB pathway, Biomed Mater 16(3) (2021).
[7] X.F. Hu, Y.F. Feng, G. Xiang, W. Lei, L. Wang, Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone, Journal of Materials Chemistry B 6(15) (2018) 2274-2288.
[8] F. Wang, L. Wang, Y. Feng, X. Yang, Z. Ma, L. Shi, X. Ma, J. Wang, T. Ma, Z. Yang, X. Wen, Y. Zhang, W. Lei, Evaluation of an artificial vertebral body fabricated by a tantalum-coated porous titanium scaffold for lumbar vertebral defect repair in rabbits, Sci Rep 8(1) (2018) 8927.
[9] X.F. Hu, L. Wang, G. Xiang, W. Lei, Y.F. Feng, Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: Critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes, Acta biomaterialia 73 (2018) 470-487.
[10] X.F. Hu, L. Wang, Y.Z. Lu, G. Xiang, Z.X. Wu, Y.B. Yan, Y. Zhang, X. Zhao, Y. Zang, L. Shi, W. Lei, Y.F. Feng, Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro, Acta biomaterialia 61 (2017) 233-248.