Personal profile

Dr. Xuehua Pan obtained his Ph.D. in Molecular Biology from The Hong Kong Polytechnic University in 2015. From 2018 to 2024, he primarily worked in the industry, focusing on preclinical research of protein and nucleic acid therapeutics. In 2024, he joined Professor Jixian Zhai's research group at Southern University of Science and Technology (SUSTech) to investigate the molecular mechanisms of plant poly(A)-related proteins and the development of nucleic acid therapeutics

Research

Study of the molecular mechanisms of plant Poly(A)-related proteins;

Research of nucleic acid therapeutics;

Selected Publication

1. Feng S, Rcheulishvili N, Jiang X, Zhu P, Pan X, Wei M, Wang PG, Ji Y, Papukashvili D. A review on Gaucher disease: therapeutic potential of β-glucocerebrosidase-targeted mRNA/saRNA approach. Int J Biol Sci. 2024 Mar 17;20(6):2111-2129

2. Qiu X, Li N, Yang Q, Wu S, Li X, Pan X, Yamamoto S, Zhang X, Zeng J, Liao J, He C, Wang R, Zhao Y. The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy. 2023 Nov;19(11):2884-2898

3. Wang X, Liu C, Rcheulishvili N, Papukashvili D, Xie F, Zhao J, Hu X, Yu K, Yang N, Pan X, Liu X, Wang PG, He Y. Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa. NPJ Vaccines. 2023 May 25;8(1):76

4. Gaurav AK, Afrin M, Yang X, Saha A, Sayeed SKA, Pan X, Ji Z, Wong KB, Zhang M, Zhao Y, Li B. The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression. Nat Commun. 2023 Mar 22;14(1):1576.

5. Shen Z, Liu C, Wang Z, Xie F, Liu X, Dong L, Pan X, Zeng C, Wang PG. Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery. Pharmaceutics. 2023 Feb 1;15(2):477.

6. Rcheulishvili N, Mao J, Papukashvili D, Liu C, Wang Z, Zhao J, Xie F, Pan X, Ji Y, He Y, Wang PG. Designing multi-epitope mRNA construct as a universal influenza vaccine candidate for future epidemic/pandemic preparedness. Int J Biol Macromol. 2023 Jan 31;226:885-899.

7. Afrin M, Gaurav AK, Yang X, Pan X, Zhao Y, Li B. “TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing”. Science Advances. (2020) 18; 6(38).

8. He, Y, Lei, J, Pan, X. et al. “The hydrolytic water molecule of Class A β-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis”. Scientific reports (2020), 10: 10205

9. Pan X, He Y, Chan K, et al. “Modified penicillin with carbapenem-like stereochemistry as specific inhibitor of Class C β-lactamases”. Antimicrobial Agents and Chemotherapy, 2017: AAC. 01288-17.

10. Pan X, He Y, Lei J, et al. “Crystallographic snapshots of Class A β-lactamase catalysis reveal structural changes that facilitate β-lactam hydrolysis”. Journal of Biological Chemistry (2017), 292(10): 4022-4033.

11. Pan X, Wong WT, He Y, Jiang Y and Zhao Y. “Perturbing the general base residue Glu166 in the active site of Class A β-lactamase leads to enhanced carbapenem binding and acylation”. Biochemistry (2014),53:5414-5423.

12. Guo J, Pan X, Zhao Y, Chen S. “Engineering Clostridia Neurotoxins with elevated catalytic activity”. Toxicon (2013),74:158-66

Patents

1. Carbohydrate-Cholesterol Structures, Liposomal Nanoparticles, Compositions and their Applications, Patent Application No.: 2024105353785, Inventors: Wang Peng, Zeng Chen, Zhu Guofeng, Liu Xingwu, Du Linlin, Liu Xiaoyi, Pan Xuehua.

2. A Carbohydrate-Lipid Molecule, Drug Delivery Carrier, Drug Complex, and Its Applications, Patent Application No.: 2024105366874, Inventors: Wang Peng, Cheng Hanchao, Liang Zhifen, Zhu Guofeng, Jin Jiahui, Pan Xuehua.

3. Deuterium-Labeled Capping Compound for mRNA Synthesis, Its Preparation Method and Applications, Patent Application No.: CN117820388A, Inventors: Cao Xuefeng, Yu Hongchao, Pan Xuehua, Ding Shuo, Chen Tianyu.

4. Fluorescent Probe for Detecting Butyrylcholinesterase and Its Applications, Patent Application No.: 201810247083.2, Inventor: Pan Xuehua.

5. Class C β-Lactamase Inhibitors, Their Preparation Methods and Applications, Patent No.: ZL 2017 1 0790073.9, Inventors: Pan Xuehua, He Yunjiao, Chen Jianhui, Zhao Yanxiang.

6. Synthesis Method for 3,5-Disubstituted Pyrazole, Patent No.: 200710094137, Inventors: Li Jianyuan, Pan Xuehua, Ji Li, He Haiying.