个人简介：

潘雪华博士2015年于香港理工大学获得分子生物学博士学位，2018年至2024年主要在企业从事蛋白和核酸药物临床前研究，2024年加入南方科技大学翟继先教授课题组，研究植物polyA相关蛋白的分子机制以及核酸药物的开发。

研究领域：

植物polyA相关蛋白的分子机制；

核酸药物研究。

学术成果：

论文

1. Feng S, Rcheulishvili N, Jiang X, Zhu P, Pan X, Wei M, Wang PG, Ji Y, Papukashvili D. A review on Gaucher disease: therapeutic potential of β-glucocerebrosidase-targeted mRNA/saRNA approach. Int J Biol Sci. 2024 Mar 17;20(6):2111-2129

2. Qiu X, Li N, Yang Q, Wu S, Li X, Pan X, Yamamoto S, Zhang X, Zeng J, Liao J, He C, Wang R, Zhao Y. The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy. 2023 Nov;19(11):2884-2898

3. Wang X, Liu C, Rcheulishvili N, Papukashvili D, Xie F, Zhao J, Hu X, Yu K, Yang N, Pan X, Liu X, Wang PG, He Y. Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa. NPJ Vaccines. 2023 May 25;8(1):76

4. Gaurav AK, Afrin M, Yang X, Saha A, Sayeed SKA, Pan X, Ji Z, Wong KB, Zhang M, Zhao Y, Li B. The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression. Nat Commun. 2023 Mar 22;14(1):1576.

5. Shen Z, Liu C, Wang Z, Xie F, Liu X, Dong L, Pan X, Zeng C, Wang PG. Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery. Pharmaceutics. 2023 Feb 1;15(2):477.

6. Rcheulishvili N, Mao J, Papukashvili D, Liu C, Wang Z, Zhao J, Xie F, Pan X, Ji Y, He Y, Wang PG. Designing multi-epitope mRNA construct as a universal influenza vaccine candidate for future epidemic/pandemic preparedness. Int J Biol Macromol. 2023 Jan 31;226:885-899.

7. Afrin M, Gaurav AK, Yang X, Pan X, Zhao Y, Li B. “TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing”. Science Advances. (2020) 18; 6(38).

8. He, Y, Lei, J, Pan, X. et al. “The hydrolytic water molecule of Class A β-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis”. Scientific reports (2020), 10: 10205

9. Pan X, He Y, Chan K, et al. “Modified penicillin with carbapenem-like stereochemistry as specific inhibitor of Class C β-lactamases”. Antimicrobial Agents and Chemotherapy, 2017: AAC. 01288-17.

10. Pan X, He Y, Lei J, et al. “Crystallographic snapshots of Class A β-lactamase catalysis reveal structural changes that facilitate β-lactam hydrolysis”. Journal of Biological Chemistry (2017), 292(10): 4022-4033.

11. Pan X, Wong WT, He Y, Jiang Y and Zhao Y. “Perturbing the general base residue Glu166 in the active site of Class A β-lactamase leads to enhanced carbapenem binding and acylation”. Biochemistry (2014),53:5414-5423.

12. Guo J, Pan X, Zhao Y, Chen S. “Engineering Clostridia Neurotoxins with elevated catalytic activity”. Toxicon (2013),74:158-66

专利

1. 糖类胆固醇结构、脂质体纳米颗粒、组合物及其应用， 专利申请号：2024105353785，王鹏,曾臣,朱国锋,刘兴武,杜琳琳,刘晓艺,潘雪华

2. 一种糖类脂质分子、药物递送载体、药物复合物及其用途，专利申请号：2024105366874， 王鹏,程汉超,梁志芬,朱国锋,金佳慧,潘雪华

3. 一种用于mRNA合成的氘代加帽化合物及其制备方法和应用，专利申请号：CN117820388A，曹学峰 于宏超 潘雪华 丁硕，陈天毓。

4. 用于检测丁酰胆碱酯酶的荧光探针及其应用, 专利申请号： 201810247083.2，潘雪华。

5. C类β-内酰胺酶抑制剂及其制备方法和应用，专利号：ZL 2017 1 0790073.9，潘雪华，贺云娇，陈建辉，赵燕湘。

6. 一种3，5二取代吡唑的合成方法，专利号：200710094137 李建源，潘雪华，季丽，贺海鹰。