师资
个人简介
曹惠玲，南方科技大学医学院生物化学系长聘副教授(研究员），博导，国家优青，深圳市海外高层次人才。长期从事骨骼发育与稳态调节及骨相关疾病研究。担任国际华人骨科研究协会（ICMRS）终身会员，国际华人骨科研究协会（ICMRS）青委会主席，中国医师协会基础学组及骨关节炎学组委员, 中华医学会骨科学分会第十一届委员会创新与转化学组青年委员会副组长等职务。担任国自然基金委函评及会评专家（优青、重点、面上、地方、青年等），广东省及湖南省杰青、优青等项目评审专家。
1. 担任《Cell Host & Microbe》、《Nature Communications》、《Advanced Materials》、《Signal Transduction and Targeted Therapy 》、《Bone Research》、 《Cellular & Molecular Immunology 》、《Acta Pharmaceutica Sinica B 》、《Advanced Science》等杂志审稿人 。
2. 主持国自然重点项目、优秀青年基金项目、国际合作项目、面上项目、青年基金及科技部重大专项课题等。
3. 相关研究成果在《Journal of Clinical Investigation》、《Nature Communications》、 《Nature Aging》 、《Cell Reports Medicine》、《Protein & cell》、《Molecular Therapy》、《Signal Transduction and Targeted Therapy》、《Acta Pharmaceutica Sinica B》、《Diabetes》、《Bone Research》 、《Journal of Biological Chemistry》、《 JCI Insight》等国际一流杂志上发表文章50余篇，参编专著两部，获批发明专利8项。H指数=32。
4. 指导的博士研究生丁镇获评南科大2026研究生十佳毕业生、校级优博；指导博士、硕士多次获得国家奖学金；指导博士研究生获国自然博士研究生项目（青年学生基础研究项目 (博士研究生)）；指导博士后获得国自然青年项目、博士后基金等。
研究领域
（1）骨骼稳态与相关疾病，如骨松，骨性关节炎等；
（2）骨与骨外器官对话机制；
（3）糖、脂代谢调节机制。
工作经历
2026/06- 南方科技大学 医学院 终身副教授（研究员）
2021/04-2026/05 南方科技大学 医学院 副教授（研究员）
2020/03-2021/03 南方科技大学 医学院 研究副教授（副研究员）
2017/01-2020/02 南方科技大学 生物系 研究副教授（副研究员）
2014/11-2016/12 南方科技大学 生物系 讲师
2010/07-2011/08 美国匹兹堡大学 医学院 博士后
学习经历
2004-09-2010-07 天津医科大学-美国匹兹堡大学联合培养 免疫学 博士
1999-09-2004-07 天津医科大学 医学检验 学士
所获荣誉
2026年南科大第三届“良师益友”优秀研究生导师称号
2026年南科大优秀研究生指导教师奖
2016 ASBMR Young Investigator Travel Grant, 2016 Plenary Poster，ASBMR 2016 Annual Meeting, September 16-19, 2016, Atlanta, Georgia, USA
2012 Chinese National Excellent Doctoral Dissertation nomination（2012 年全国优秀博士学位论文提名论文）（Only 278 dissertations were nominated in 2012） “Activating transcription factor 4 regulates osteoclast differentiation in mice”, Chinese Ministry of Education, 2012
2012 Excellent Doctoral Dissertation Award （2012 年天津市优秀博士学位论文） Tianjin city, China, 2012
2011 ASBMR Young Investigator Award, 2011（青年研究员奖） ASBMR (American Society for Bone and Mineral Research) annual meeting, 2011, San Diego, California, USA
2011 Young Investigator Award（青年研究员奖） 9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium, 2011, Nanjing, China
2010 Excellent PhD Graduate Award（2010 年天津医科大学优秀博士毕业生） Tianjin medical university, China, 2010
学术成果
科研论文:
1. Li, X.#, Ma, G.#*, Wang, F.#, Ding, Z., Chen, Y., Cheng, S., Pang, W., Chen, L., Cao, H.* (2026) Kindlin-2 functional restoration through methylmalonic acid clearance by Coenzyme A counteracts osteoporosis. Molecular Therapy. S1525-0016(26)00402-8.
2. Ma, G.#, Chen, Y.#, Cheng, S., Wang, F., Han, Y., Chen, L., Ding, Z., Li, Y., Cao, H.* Targeting the Ip6k2–Runx2 axis disrupts osteoblast–osteoclast coupling to treat osteoporosis. Nature Communications. 2026 Jun 30;17(1):8130.
3. Chen, Y., Wang, F., Ma, G.*, Cao, H.* (2026) Kindlin protein family: physiology, pathology, and implications for development and disease. Oral Science and Homeostatic Medicine, 2(1) （Cover article）
4. Wang, H., Zhang, L., Zhang, Y., Wang, W., Ni, J., Liu, J., Gong, W., Au, M. T., Yeung, M. H. Y., Cao, H., and Wen, C. (2025) Spatially resolved single-cell-based histocytomorphometry for growth plate analysis across multiple species. Journal of Orthopaedic Translation, 101015
5. Chen, Y.#, Pang, W.#, Ma, G.#, Yan, Y., Xiao, Z., Chen, Y., Ding, Z., Chen, L., Hou, X., and Cao, H.* (2025) March5-mediated Trim28 degradation preserves islet β-cell function in mice. Nature Communications 16, 7073
6. Zhou, B.#, Huang, H.#, Ding, Z.#, Luo, K., Chen, Y., Han, Y., Pang, W., Tang, W., Chen, L., Jin, W.*, Ma, G.*, and Cao, H.* (2025) Unveiling two distinct osteolineage cell populations linked to age-related osteoporosis in adult mice through integrative single-cell analyses. Cellular and Molecular Life Sciences 82, 106
7. Ma, G.#, Cheng, S.#, Han, Y.#, Tang, W., Pang, W., Chen, L., Ding, Z., and Cao, H.1* (2025) The p53-miR17 family-Rankl axis bridges liver-bone communication. Molecular Therapy 33, 631–648
8. Ma, G.#, Han, Y.#, Tang, W., Zhou, B., Chen, L., Ding, Z., Cheng, S., Chen, D.*, and Cao, H.* (2024) Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis. Protein & Cell 16, 497–502
9. Ding, Z., Ma, G., Zhou, B., Cheng, S., Tang, W., Han, Y., Chen, L., Pang, W., Chen, Y., Yang, D., and Cao, H.* (2024) Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells. Cell Reports Medicine 5, 101665
10. Wu, Y., Jing, H., Li, Y., Li, M., Zheng, Y., Lin, Y., Ma, G., Cao, H.*, and Yang, H.* (2024) NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-β signaling pathway. Cellular and Molecular Life Sciences 81, 338
11. Dong, Y., Yuan, H., Ma, G.*, and Cao, H.* (2024) Bone-muscle crosstalk under physiological and pathological conditions. Cellular and Molecular Life Sciences 81, 310
12. Chen, Y., Guo, B., Ma, G.*, and Cao, H.* (2024) Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases. Ageing Research Reviews 99, 102372
13. Tang, W.#, Ding, Z.#, Gao, H.#, Yan, Q.#, Liu, J., Han, Y., Hou, X., Liu, Z., Chen, L., Yang, D.*, Ma, G.*, and Cao, H.* (2023) Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice. Acta Pharmaceutica Sinica B 13, 4535–4552
14. Dong, Y.#, Ma, G.#*, Hou, X.#, Han, Y.#, Ding, Z., Tang, W., Chen, L., Chen, Y., Zhou, B., Rao, F., Lv, K., Du, C., and Cao, H.* (2023) Kindlin-2 controls angiogenesis through modulating Notch1 signaling. Cellular and Molecular Life Sciences 80, 223
15. Hou, X.#, Chen, Y.#, Zhou, B., Tang, W., Ding, Z., Chen, L., Wu, Y., Yang, H., Du, C., Yang, D., Ma, G.*, and Cao, H.* (2023) Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice. Cell Death & Disease 14, 709
16. He, T.#, Zhou, B.#, Sun, G.#, Yan, Q., Lin, S., Ma, G., Yao, Q., Wu, X., Zhong, Y., Gan, D., Huo, S., Jin, W., Chen, D., Bai, X.*, Cheng, T.*, Cao, H.*, and Xiao, G.* (2024) The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death & Differentiation 31, 90–105
17. Gao, H.#, Zhong, Y.#, Zhou, L.#, Lin, S.#, Hou, X.#, Ding, Z., Li, Y., Yao, Q., Cao, H., Zou, X., Chen, D., Bai, X., and Xiao, G. (2023) Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. eLife 12, e81792
18. Dong, Y.#, Chen, Y.#, Ma, G., and Cao, H.* (2023) The role of E3 ubiquitin ligases in bone homeostasis and related diseases. Acta Pharmaceutica Sinica B 13, 3963–3987
19. Liu, Z.#, Tang, W.#, Liu, J.#, Han, Y., Yan, Q., Dong, Y., Liu, X., Yang, D., Ma, G.*, and Cao, H.* (2023) A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound. Bioactive Materials 20, 610–626
20. Chen, S #, Wu, X #, Lai, Y., Chen, D., Bai, X., Liu, S., Wu, Y., Chen, M., Lai, Y., Cao, H.*, Shao, Z.*, and Xiao, G.* (2022) Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Research 10, 5
21. Chen, S.#, Chen, M.#, Wu, X.#, Lin, S., Tao, C., Cao, H.*, Shao, Z.*, and Xiao, G.* (2022) Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019. Journal of Orthopaedic Translation 32, 49–58
22. Wu, X.#, Lai, Y.#, Chen, S.#, Zhou, C., Tao, C., Fu, X., Li, J., Tong, W., Tian, H., Shao, Z., Liu, C., Chen, D., Bai, X.*, Cao, H.*, and Xiao, G.* (2022) Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nature Aging 2, 332–347
23. Gao, H.#, Zhou, L.#, Zhong, Y.#, Ding, Z.#, Lin, S., Hou, X., Zhou, X., Shao, J., Yang, F., Zou, X., Cao, H.*, and Xiao, G.* (2022) Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice. Nature Communications 13, 1025
24. Qin, L.#, Liu, N.#, Bao, C.-l.-m.#, Yang, D.-z., Ma, G.-x., Yi, W.-h.*, Xiao, G.-z.*, and Cao, H.-l.* (2023) Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin. Acta Pharmacologica Sinica 44, 268–287
25. Sadeghzade, S., Liu, J., Wang, H., Li, X., Cao, J., Cao, H., Tang, B., and Yuan, H. (2022) Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review). Materials Today Bio 17, 100473
26. Gao, H.#, Zhong, Y.#, Ding, Z.#, Lin, S.#, Hou, X., Tang, W., Zhou, X., Zou, X., Shao, J., Yang, F., Bai, X., Liu, C., Cao, H.*, and Xiao, G.* (2021) Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice. Diabetes 70, 2492–2505
27. Qin, L.#, He, T.#, Chen, S.#, Yang, D., Yi, W.*, Cao, H.*, and Xiao, G.* (2021) Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Research 9, 44
28. Qin, L.#, Fu, X.#, Ma, J., Lin, M., Zhang, P., Wang, Y., Yan, Q., Tao, C., Liu, W., Tang, B., Chen, D., Bai, X., Cao, H.*, and Xiao, G.* (2021) Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Communications Biology 4, 402
29. Qin, L., Yang, D., Yi, W.*, Cao, H.*, and Xiao, G.* (2021) Roles of leader and follower cells in collective cell migration. Molecular Biology of the Cell 32, 1267–1272
30. Cao, H.#*, Yan, Q.#, Wang, D.#, Lai, Y., Zhou, B., Zhang, Q., Jin, W., Lin, S., Lei, Y., Ma, L., Guo, Y., Wang, Y., Wang, Y., Bai, X., Liu, C., Feng, J. Q., Wu, C., Chen, D., Cao, X., and Xiao, G.* (2020) Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Research 8, 2
31. Zhu, K., Lai, Y., Cao, H., Bai, X., Liu, C., Yan, Q., Ma, L., Chen, D., Kanaporis, G., Wang, J., Li, L., Cheng, T., Wang, Y., Wu, C.*, and Xiao, G.* (2020) Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nature Communications 11, 484
32. Qin, L., Liu, W., Cao, H.*, and Xiao, G.* (2020) Molecular mechanosensors in osteocytes. Bone Research 8, 23
33. Lei, Y.#, Fu, X.#, Li, P.#, Lin, S., Yan, Q., Lai, Y., Liu, X., Wang, Y., Bai, X., Liu, C., Chen, D., Zou, X., Cao, X., Cao, H.*, and Xiao, G.* (2020) LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research 8, 37
34. Fu, X.#, Zhou, B.#, Yan, Q.#, Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., Shao, Z., Wang, M., Chen, D., Jin, W., Song, Y., Cao, H.*, Zhang, G.*, and Xiao, G.* (2020) Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduction and Targeted Therapy 5, 297
35. Gao, H.#, Guo, Y.#, Yan, Q.#, Yang, W., Li, R., Lin, S., Bai, X., Liu, C., Chen, D., Cao, H.*, and Xiao, G.* (2019) Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight 4
36. Wang, Y., Yan, Q., Zhao, Y., Liu, X., Lin, S., Zhang, P., Ma, L., Lai, Y., Bai, X., Liu, C., Wu, C., Feng, J. Q., Chen, D., Cao, H. *, and Xiao, G.* (2019) Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight 4
37. Yang, X., Xia, R., Yue, C., Zhai, W., Du, W., Yang, Q., Cao, H., Chen, X., Obando, D., Zhu, Y., Chen, X., Chen, J.-J., Piganelli, J., Wipf, P., Jiang, Y., Xiao, G., Wu, C., Jiang, J., and Lu, B. (2018) ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming. Cell Reports 23, 1754–1766
38. Xu, H., Cao, H., and Xiao, G. (2016) Signaling via PINCH: Functions, binding partners and implications in human diseases. Gene 594, 10–15
39. Wu, C.#*, Jiao, H.#, Lai, Y.#, Zheng, W., Chen, K., Qu, H., Deng, W., Song, P., Zhu, K., Cao, H., Galson, D. L., Fan, J., Im, H.-J., Liu, Y., Chen, J., Chen, D., and Xiao, G.* (2015) Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis. Nature Communications 6, 7531
40. Qin, T.-T., Xu, G.-C., Qi, J.-W., Yang, G.-L., Zhang, K., Liu, H.-L., Xu, L.-X., Xiang, R., Xiao, G., Cao, H., Wei, Y., Zhang, Q.-Z., and Li, L.-Y. (2015) Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells. The Journal of Pathology 237, 307–318
41. Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D., and Kurihara, N. (2013) Role of ATF7‐TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease. Journal of Bone and Mineral Research 28, 1489–1500
42. Zhu, K., Jiao, H., Li, S., Cao, H., Galson, D. L., Zhao, Z., Zhao, X., Lai, Y., Fan, J., Im, H. J., Chen, D., and Xiao, G. (2013) ATF4 promotes bone angiogenesis by increasing vegf expression and release in the bone environment. Journal of Bone and Mineral Research 28, 1870–1884
43. Cao, H., Zhu, K., Qiu, L., Li, S., Niu, H., Hao, M., Yang, S., Zhao, Z., Lai, Y., Anderson, J. L., Fan, J., Im, H.-J., Chen, D., Roodman, G. D., and Xiao, G. (2013) Critical Role of AKT Protein in Myeloma-induced Osteoclast Formation and Osteolysis. Journal of Biological Chemistry 288, 30399–30410
44. Xiao, G.#*, Cheng, H.#, Cao, H.#, Chen, K., Tu, Y., Yu, S., Jiao, H., Yang, S., Im, H.-J., Chen, D., Chen, J.*, and Wu, C.* (2012) Critical Role of Filamin-binding LIM Protein 1 (FBLP-1)/Migfilin in Regulation of Bone Remodeling. Journal of Biological Chemistry 287, 21450–21460
45. Yang, S., Xu, H., Yu, S., Cao, H., Fan, J., Ge, C., Fransceschi, R. T., Dong, H. H., and Xiao, G. (2011) Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts. Journal of Biological Chemistry 286, 19149–19158
46. Cao, H.#, Yu, S.#, Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D., and Xiao, G. (2010) Activating transcription factor 4 regulates osteoclast differentiation in mice. The Journal of Clinical Investigation 120, 2755–2766
发明专利:
1. 专利号：ZL 2017 1 0180991.X，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗糖尿病的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-04-28，公告（公开）日期：2017-09-01。
2. 专利号：ZL 2017 1 0169753.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗肾炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。
3. 专利号：ZL 2017 1 0170718.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗骨性关节炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。
4. 专利申请号：2021101129689，发明专利，名称：抑制肝细胞中Kindlin-2蛋白表达量的试剂在制备治疗脂肪肝产品中的应用，发明人：肖国芝，曹惠玲，高焕庆，实审阶段，申请日期：2021/1/27。
5. 专利申请号：202210513385.6，发明专利，名称：一种水凝胶喷雾及其制备方法与应用，发明人：曹惠玲，马贵兴，刘正伟，实审，申请日期：2022/05/12。
6. 专利号：ZL 2022 1 1211629.1，发明专利，Kindlin-2作为靶点在皮肤创伤修复中的应用，发明人：曹惠玲，马贵兴，申请日期：2022-09-30，授权公告日：2023-12-01。
7. 专利申请号：202210877899X，Kindlin-2作为靶点在治疗骨质疏松及预防癌症骨转移中的应用，发明人：曹惠玲，马贵兴，实审阶段，申请日期：2022/07/25。
8. 专利申请号：202310435009.4，发明专利，抑制脂肪细胞中 Kindlin-2 蛋白表达的试剂在制备治疗关节炎产品中的应用，发明人：曹惠玲，马贵兴，实审阶段，公告（公开）日期：2023-07-21。