个人简介

南方科技大学医学院研究员，国家优青获得者。主要从事骨骼发育与稳态调节及骨相关疾病（骨质疏松症、骨性关节炎等）研究、糖脂代谢研究。国际华人骨科研究协会（ICMRS）终身会员，国际华人骨科研究协会青年发展委员会委员，中国免疫学会广东省免疫学会血液免疫学专业委员会委员，中华医学会骨科学分会第十一届委员会创新与转化学组青年委员会副组长，美国骨矿研究协会（ASBMR）会员，广东省医师协会运动损伤委员会基础研究和医工结合学组副组长 。担任《Bone Research》、《Stem Cell Research & Therapy》、《Stem Cells Translational Medicine》、《Journal of cell physiology》等杂志审稿人 。国自然基金委重大研究计划培育项目、面上项目、青年基金等项目评审专家。主持或参与国自然重点项目、重大项目、优秀青年基金项目、面上项目及青年基金、科技部重大专项、广东省重点实验室、深圳市科创委基础研究项目等。相关研究成果在《Journal of Clinical Investigation》、《 Nature Communications》、《Signal Transduction and Targeted Therapy》、《 Bone Research》 、《Journal of Biological Chemistry》、 《 JCI Insight》等国际一流杂志上发表论文多篇，获批发明专利三项。

研究领域

1. 破骨细胞、成骨细胞的形成、分化的分子机制；
2. 骨重塑的分子机制；
3. 癌症骨转移；
4. 骨血管生成的分子机制。

工作经历

2021/04- 至今       南方科技大学 医学院 研究员 

2020/03-2021/03 南方科技大学 医学院 研究副教授（副研究员） 

2017/01-2020/02 南方科技大学 生物系 研究副教授（副研究员）   

2014/11-2016/12 南方科技大学 生物系 讲师   

2010/07-2011/08 美国匹兹堡大学 医学院 博士后

学习经历

2004-09-2010-07 天津医科大学-美国匹兹堡大学联合培养 免疫学 博士
1999-09-2004-07 天津医科大学 医学检验 学士

所获荣誉

2016 ASBMR Young Investigator Travel Grant, 2016 Plenary Poster，ASBMR 2016 Annual Meeting, September 16-19, 2016, Atlanta, Georgia, USA
2012 Chinese National Excellent Doctoral Dissertation nomination（2012 年全国优秀博士学位论文提名论文）（Only 278 dissertations were nominated in 2012） “Activating transcription factor 4 regulates osteoclast differentiation in mice”, Chinese Ministry of Education, 2012
2012 Excellent Doctoral Dissertation Award （2012 年天津市优秀博士学位论文） Tianjin city, China, 2012
2011 ASBMR Young Investigator Award, 2011（青年研究员奖） ASBMR (American Society for Bone and Mineral Research) annual meeting, 2011, San Diego, California, USA
2011 Young Investigator Award（青年研究员奖） 9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium, 2011, Nanjing, China
2010 Excellent PhD Graduate Award（2010 年天津医科大学优秀博士毕业生） Tianjin medical university, China, 2010

学术成果

全长研究论文（Original Full-Length Peer-Reviewed Research Papers）:

1. Yu S., Franceschi R.T., Luo M., Fan J., Jiang D., Cao H., Kwon T.G., Lai Y., Zhang J., Patrene K., Hankenson K., Roodman G.D., and Xiao G., Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One, 2009. 4(10): p. e7583. PMCID: PMC2762317

2. Cao H.#, Yu S.#, Yao Z., Galson D.L., Jiang Y., Zhang X., Fan J., Lu B., Guan Y., Luo M., Lai Y., Zhu Y., Kurihara N., Patrene K., Roodman G.D., and Xiao G., Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest, 2010. 120(8): p. 2755-66. PMCID: PMC2912190

3. Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., Fransceschi R.T., Dong H.H., and Xiao G., Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem, 2011. 286(21): p. 19149-58. PMID: 21471200.

4. Xiao G.#*, Cheng H.#, Cao H.#, Chen K., Tu Y., Yu S., Jiao H., Yang S., Im H.J., Chen D., Chen J.*, and Wu C.*, Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem, 2012. 287(25): p. 21450-60. PMID: 22556421

5. Teramachi J., Hiruma Y., Ishizuka S., Ishizuka H., Brown J.P., Michou L., Cao H., Galson D.L., Subler M.A., Zhou H., Dempster D.W., Windle J.J., Roodman G.D., and Kurihara N., Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease. J Bone Miner Res, 2013. 28(6): p. 1489-50. PMID:23426901

6. Zhu K., Jiao H., Li S., Cao H., Galson D.L., Zhao Z., Zhao X., Lai Y., Fan J., Im H.J., Chen D., and Xiao G., ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res, 2013. 28(9): p. 1870-1884. PMID:23649506

7. Cao H., Zhu K., Qiu L., Li S., Niu H., Hao M., Yang S., Zhao Z., Lai Y., Anderson J.L., Fan J., Im H.J., Chen D., Roodman G.D., and Xiao G., Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem, 2013. 288(42): p. 30399-410. PMID:24005670

8. Qin T.T., Xu G.C., Qi J.W., Yang G.L., Zhang K., Liu H.L., Xu L.X., Xiang R., Xiao G., Cao H., Wei Y., Zhang Q.Z., and Li L.Y., Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol, 2015. 237(3): p. 307-18. PMID: 26096340

9. Wu C. #*, Jiao H.#, Lai Y.#, Zheng W., Chen K., Qu H., Deng W., Song P., Zhu K., Cao H., Galson D.L., Fan J., Im H.J., Liu Y., Chen J., Chen D., and Xiao G.*, Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat Commun, 2015. 6: p. 7531. PMID: 26151572

10. Yang X., Xia R., Yue C., Zhai W., Du W., Yang Q., Cao H., Chen X., Obando D., Zhu Y., Chen X., Chen J.J., Piganelli J., Wipf P., Jiang Y., Xiao G., Wu C., Jiang J., and Lu B., ATF4 Regulates CD4(+) T Cell Immune Responses through Metabolic Reprogramming. Cell Rep, 2018. 23(6): p. 1754-1766. PMID:29742431

11. Gao H.#, Guo Y.#, Yan Q.#, Yang W., Li R., Lin S., Bai X., Liu C., Chen D., Cao H.*, and Xiao G.*, Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight, 2019. 4(13). PMID:31292295

12. Wang Y., Yan Q., Zhao Y., Liu X., Lin S., Zhang P., Ma L., Lai Y., Bai X., Liu C., Wu C., Feng J.Q., Chen D., Cao H.*, and Xiao G.*, Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight, 2019. 4(22). PMID: 31723057

13. Cao H.#*, Yan Q.#, Wang D.#, Lai Y., Zhou B., Zhang Q., Jin W., Lin S., Lei Y., Ma L., Guo Y., Wang Y., Wang Y., Bai X., Liu C., Feng J.Q., Wu C., Chen D., Cao X., and Xiao G.*, Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Research, 2020. 8(1): p. 2. PMID: 31934494.

14. Zhu K., Lai Y., Cao H., Bai X., Liu C., Yan Q., Ma L., Chen D., Kanaporis G., Wang J., Li L., Cheng T., Wang Y., Wu C.*, and Xiao G.*, Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun, 2020. 11(1): p. 484. PMID: 31980627

15. Chen S., Qin L., Wu X., Fu X., Lin S., Chen D., Xiao G., Shao Z.*, and Cao H.*, Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells. Front Cell Dev Biol, 2020. 8: p. 127. PMID: 32195253

16. Yiming Lei#, Xuekun Fu#, Pengyu Li#, Sixiong Lin, Qinnan Yan, Yumei Lai, Xin Liu, Yishu Wang, Xiaochun Bai, Chuanju Liu, Di Chen, Huiling Cao*, Guozhi Xiao*. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research, Oct 13, 2020, 8(37). DOI: 10.1038/s41413-020-00108-y.

17. Fu X.#, Zhou B.#, Yan Q.#, Tao C., Qin L., Wu X., Lin S., Chen S., Lai Y., Zou X., Shao Z., Wang M., Chen D., Jin W., Song Y., Cao H.*, Zhang G.*, Xiao G.*¬, Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduct Target Ther. Dec 26, 2020, 5(1). DOI: 10.1038/s41392-020-00328-y.

18. Lei Qin, Xuekun Fu, Jing Ma, Manxia Lin, Peijun Zhang, Yishu Wang, Qingnan Yan, Chu Tao, Wen Liu, Bing Tang, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Communications Biology, Mar 25, 2021,4(1). DOI: 10.1038/s42003-021-01950-4.

19.  Huanqing Gao#, Yiming Zhong#, Zhen Ding#, Sixiong Lin#, Xiaoting Hou, Wanze Tang, Xiaoqian Zhou, Xuenong Zou, Jie Shao, Fan Yang, Xiaochun Bai, Chuanju Liu, Huiling Cao*, Guozhi Xiao*. Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice. Diabetes, 2021 Nov;70(11):2492-2505. doi: 10.2337/db21-0392

20.  Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Kindlin-2 inhibits NLRP3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res., Jan 10, 2022, 10 (5). Doi: 10.1038/s41413-021-00179-5

21.  Xiaohao Wu, Yumei Lai, Sheng Chen, Chunlei Zhou, Chu Tao, Xuekun Fu, Jun Li, Jian Huang, Wei Tong, Hongtao Tian, Zengwu Shao, Chuanju Liu, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nature Aging, Feb 10, 2022. https://doi.org/10.1038/s43587-021-00165-w

22.  Huanqing Gao1#, Liang Zhou2#, Yiming Zhong1#, Zhen Ding1#, Sixiong Lin1,3, Xiaoting Hou1, Xiaoqian Zhou4, Jie Shao5, Fan Yang5, Xuenong Zou3, Huiling Cao1*, Guozhi Xiao1*, Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice, Nat Commun, Feb 23, 2022.  13:1025 | https://doi.org/10.1038/s41467-022-28692-z.

23.  Zhengwei Liu1#, Wanze Tang1#, Jiayi Liu2#, Yingying Han1, Qinnan Yan1, Yuechao Dong1, Xiaomei Liu1a, Dazhi Yang3, Guixing Ma1*, Huiling Cao1*, A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound. Bioact Mater, volume 20, February 2023, Pages 610-626. https://doi.org/10.1016/j.bioactmat.2022.06.008

综述及专著章节（Review articles and Book Chapters）:

1. Xu H, Cao H, Xiao G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene. 2016 Aug 30. PMID: 27590440

2. Cao H#*, Xiao G* (2018): Kindlin Signaling and Bone. 《Encyclopedia of Bone Biology 》(Book chapter) by Dr. Mone Zaidi et al. Available online 29 July 2019. ISBN 978-0-12-814081-9. https://doi.org/10.1016/B978-0-12-801238-3.11176-6

3. 曹惠玲，杨玮，肖国芝 (2018): 软骨细胞.《骨发育与骨疾病的现代研究》(书号：ISBN 978-7-313-20582-7, Book chapter)

4. Qin Lei, Liu Wen. Cao Huiling*, Xiao Guozhi*. Molecular mechanosensors in osteocytes. Bone Res 8, 23 (2020). https://doi.org/10.1038/s41413-020-0099-y.

5. Qin L, He T, Chen S, Cao H*, Xiao G*. Role of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Under review in Bone Res.

6. 陈胜，陈明珏，林嗣雄，曹惠玲，邵增务，肖国芝，线粒体功能障碍与椎间盘退变的研究进展，生物骨科材料与临床研究，2021.

7. Lei Qin, Dazhi Yang, Weihong Yi*, Huiling Cao*, Guozhi Xiao*. Roles of leader and follower cells in the collective cell migration. Mol Biol Cell, Jul 1, 2021, 32(14). DOI: 10.1091/mbc. E20-10-0681.

专利(Patents):

1.        专利号：ZL 2017 1 0180991.X，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗糖尿病的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-04-28，公告（公开）日期：2017-09-01。

2.        专利号：ZL 2017 1 0169753.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗肾炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。

3.        专利号：ZL 2017 1 0170718.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗骨性关节炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。

4.        专利申请号：2021101129689，发明专利，名称：抑制肝细胞中Kindlin-2蛋白表达量的试剂在制备治疗脂肪肝产品中的应用，发明人：肖国芝，曹惠玲，高焕庆，实审阶段，申请日期：2021/1/27。

5.        专利申请号：202210513385.6，发明专利，名称：一种水凝胶喷雾及其制备方法与应用，发明人：曹惠玲，马贵兴，刘正伟，已受理，申请日期：2022/05/12。

联系方式

深圳市南山区西丽学苑大道1088号南方科技大学 慧园5栋205邮编：518055
电子邮件：caohl@sustech.edu.cn