个人简介

曹惠玲，南方科技大学医学院生物化学系副教授(研究员），博导，国家优青，深圳市海外高层次人才。长期从事骨骼发育与稳态调节及骨相关疾病研究。国际华人骨科研究协会（ICMRS）终身会员，国际华人骨科研究协会（ICMRS）青委会主席，中国免疫学会广东省免疫学会血液免疫学专业委员会委员，中华医学会骨科学分会第十一届委员会创新与转化学组青年委员会副组长，广东省医师协会运动损伤委员会基础研究和医工结合学组副组长。担任《Signal Transduction and Targeted Therapy 》、《Bone Research》、 《Aging Cell》、《Acta Pharmacol Sin》等杂志审稿人 。国自然基金委函评（优青、重点、面上等）、会评（面上、地方、青年、区域联合重点等）专家。广东省及湖南省杰青、优青等项目评审专家。主持或参与国家重点研发计划、国自然重点项目、重大项目、优秀青年基金项目、面上项目及青年基金、科技部重大专项、广东省重点实验室、深圳市科创委基础研究项目等。相关研究成果在《Journal of Clinical Investigation》、《Nature Communications》、 《Nature Aging》 、《Cell Reports Medicine》、《Protein & cell》、《Molecular Therapy》、《Signal Transduction and Targeted Therapy》、《Acta Pharmaceutica Sinica B》、《Diabetes》、《Bone Research》 、《Journal of Biological Chemistry》、《 JCI Insight》等国际一流杂志上发表文章40余篇，参编专著两部，获批发明专利6项。H指数=26。 

研究领域

1. 破骨细胞、成骨细胞的形成、分化的分子机制；
2. 骨重塑的分子机制；
3. 癌症骨转移；
4. 骨血管生成的分子机制。

工作经历

2021/04- 至今       南方科技大学 医学院 研究员 

2020/03-2021/03 南方科技大学 医学院 研究副教授（副研究员） 

2017/01-2020/02 南方科技大学 生物系 研究副教授（副研究员）   

2014/11-2016/12 南方科技大学 生物系 讲师   

2010/07-2011/08 美国匹兹堡大学 医学院 博士后

学习经历

2004-09-2010-07 天津医科大学-美国匹兹堡大学联合培养 免疫学 博士
1999-09-2004-07 天津医科大学 医学检验 学士

所获荣誉

2016 ASBMR Young Investigator Travel Grant, 2016 Plenary Poster，ASBMR 2016 Annual Meeting, September 16-19, 2016, Atlanta, Georgia, USA
2012 Chinese National Excellent Doctoral Dissertation nomination（2012 年全国优秀博士学位论文提名论文）（Only 278 dissertations were nominated in 2012） “Activating transcription factor 4 regulates osteoclast differentiation in mice”, Chinese Ministry of Education, 2012
2012 Excellent Doctoral Dissertation Award （2012 年天津市优秀博士学位论文） Tianjin city, China, 2012
2011 ASBMR Young Investigator Award, 2011（青年研究员奖） ASBMR (American Society for Bone and Mineral Research) annual meeting, 2011, San Diego, California, USA
2011 Young Investigator Award（青年研究员奖） 9th International Conference on Bone and Mineral Research (ICBMR) & 11th International Osteoporosis Symposium, 2011, Nanjing, China
2010 Excellent PhD Graduate Award（2010 年天津医科大学优秀博士毕业生） Tianjin medical university, China, 2010

学术成果

科研论文:

1. Yu S., Franceschi R.T., Luo M., Fan J., Jiang D., Cao H., Kwon T.G., Lai Y., Zhang J., Patrene K., Hankenson K., Roodman G.D., and Xiao G., Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One, 2009. 4(10): p. e7583. PMCID: PMC2762317

2. Cao H.#, Yu S.#, Yao Z., Galson D.L., Jiang Y., Zhang X., Fan J., Lu B., Guan Y., Luo M., Lai Y., Zhu Y., Kurihara N., Patrene K., Roodman G.D., and Xiao G., Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest, 2010. 120(8): p. 2755-66. PMCID: PMC2912190

3. Yang S., Xu H., Yu S., Cao H., Fan J., Ge C., Fransceschi R.T., Dong H.H., and Xiao G., Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem, 2011. 286(21): p. 19149-58. PMID: 21471200.

4. Xiao G.#*, Cheng H.#, Cao H.#, Chen K., Tu Y., Yu S., Jiao H., Yang S., Im H.J., Chen D., Chen J.*, and Wu C.*, Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem, 2012. 287(25): p. 21450-60. PMID: 2255642.

5. Teramachi J., Hiruma Y., Ishizuka S., Ishizuka H., Brown J.P., Michou L., Cao H., Galson D.L., Subler M.A., Zhou H., Dempster D.W., Windle J.J., Roodman G.D., and Kurihara N., Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget’s disease. J Bone Miner Res, 2013. 28(6): p. 1489-50. PMID:23426901

6. Zhu K., Jiao H., Li S., Cao H., Galson D.L., Zhao Z., Zhao X., Lai Y., Fan J., Im H.J., Chen D., and Xiao G., ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. J Bone Miner Res, 2013. 28(9): p. 1870-1884. PMID:23649506

7. Cao H., Zhu K., Qiu L., Li S., Niu H., Hao M., Yang S., Zhao Z., Lai Y., Anderson J.L., Fan J., Im H.J., Chen D., Roodman G.D., and Xiao G., Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem, 2013. 288(42): p. 30399-410. PMID:24005670

8. Qin T.T., Xu G.C., Qi J.W., Yang G.L., Zhang K., Liu H.L., Xu L.X., Xiang R., Xiao G., Cao H., Wei Y., Zhang Q.Z., and Li L.Y., Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells. J Pathol, 237(3): p. 307-18. PMID: 26096340

9. Wu C. #*, Jiao H.#, Lai Y.#, Zheng W., Chen K., Qu H., Deng W., Song P., Zhu K., Cao H., Galson D.L., Fan J., Im H.J., Liu Y., Chen J., Chen D., and Xiao G.*, Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat Commun, 2015. 6: p. 7531. PMID: 26151572

10. Yang X., Xia R., Yue C., Zhai W., Du W., Yang Q., Cao H., Chen X., Obando D., Zhu Y., Chen X., Chen J.J., Piganelli J., Wipf P., Jiang Y., Xiao G., Wu C., Jiang J., and Lu B., ATF4 Regulates CD4(+) T Cell Immune Responses through Metabolic Reprogramming. Cell Rep, 23(6): p. 1754-1766. PMID:29742431

11. Xu H, Cao H, Xiao G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene. 2016 Aug 30. PMID: 27590440

12. 曹惠玲, 杨玮，肖国芝 (2018): 软骨细胞.《骨发育与骨疾病的现代研究》(书号：ISBN 978-7-313-20582-7, Book chapter)

13. Gao H.#, Guo Y.#, Yan Q.#, Yang W., Li R., Lin S., Bai X., Liu C., Chen D., Cao H.*, and Xiao G.*, Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. JCI Insight, 2019. 4(13). PMID:31292295

14. Cao H#*, Xiao G* (2018): Kindlin Signaling and Bone. 《Encyclopedia of Bone Biology 》(Book chapter) by Dr. Mone Zaidi et al. Available online 29 July 2019. ISBN 978-0-12-814081-9. https://doi.org/10.1016/B978-0-12-801238-3.11176-6

15. Wang Y., Yan Q., Zhao Y., Liu X., Lin S., Zhang P., Ma L., Lai Y., Bai X., Liu C., Wu C., Feng J.Q., Chen D., Cao H.*, and Xiao G.*, Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight, 2019. 4(22). PMID: 31723057

16. Cao H.#*, Yan Q.#, Wang D.#, Lai Y., Zhou B., Zhang Q., Jin W., Lin S., Lei Y., Ma L., Guo Y., Wang Y., Wang Y., Bai X., Liu C., Feng J.Q., Wu C., Chen D., Cao X., and Xiao G.*, Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Research, 2020. 8(1): p. 2. PMID: 31934494.

17. Qin Lei, Liu Wen. Cao Huiling*, Xiao Guozhi*. Molecular mechanosensors in osteocytes. Bone Res. 8, 23 (2020, Jun). https://doi.org/10.1038/s41413-020-0099-y.

18. Zhu K., Lai Y., Cao H., Bai X., Liu C., Yan Q., Ma L., Chen D., Kanaporis G., Wang J., Li L., Cheng T., Wang Y., Wu C.*, and Xiao G.*, Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun, 2020. 11(1): p. 484. PMID: 31980627

19. Chen S., Qin L., Wu X., Fu X., Lin S., Chen D., Xiao G., Shao Z.*, and Cao H.*, Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells. Front Cell Dev Biol, 2020. 8: p. 127. PMID: 32195253

20. Yiming Lei#, Xuekun Fu#, Pengyu Li#, Sixiong Lin, Qinnan Yan, Yumei Lai, Xin Liu, Yishu Wang, Xiaochun Bai, Chuanju Liu, Di Chen, Huiling Cao*, Guozhi Xiao*. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Research, Oct 13, 2020, 8(37). DOI:1038/s41413-020-00108-y.

21. Fu X.#, Zhou B.#, Yan Q.#, Tao C., Qin L., Wu X., Lin S., Chen S., Lai Y., Zou X., Shao Z., Wang M., Chen D., Jin W., Song Y., Cao H.*, Zhang G.*, Xiao G.*­, Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduct Target Ther. Dec 26, 2020, 5(1). DOI: 1038/s41392-020-00328-y.

22. Qin L, He T, Chen S, Cao H*, Xiao G*. Role of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Res. 9:44 (2021, Oct) https://doi.org/10.1038/s41413-021-00168-8

23. Lei Qin, Xuekun Fu, Jing Ma, Manxia Lin, Peijun Zhang, Yishu Wang, Qingnan Yan, Chu Tao, Wen Liu, Bing Tang, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Communications Biology, Mar 25, 2021,4(1). DOI: 10.1038/s42003-021-01950-4.

24. Lei Qin, Dazhi Yang, Weihong Yi*, Huiling Cao*, Guozhi Xiao*. Roles of leader and follower cells in the collective cell migration. Mol Biol Cell, Jul 1, 2021, 32(14). DOI: 1091/mbc. E20-10-0681.

25. Huanqing Gao#, Yiming Zhong#, Zhen Ding#, Sixiong Lin#, Xiaoting Hou, Wanze Tang, Xiaoqian Zhou, Xuenong Zou, Jie Shao, Fan Yang, Xiaochun Bai, Chuanju Liu, Huiling Cao*, Guozhi Xiao*. Pinch loss ameliorates obesity, glucose intolerance and fatty liver by modulating adipocyte apoptosis in mice. Diabetes, 2021 Nov;70(11):2492-2505. doi: 10.2337/db21-0392

26. Sheng Chen, Mingjue Chen, Xiaohao Wu, Sixiong Lin, Chu Tao, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Global, regional and national burden of low back pain 1990-2019: a systematic analysis of the Global Burden of Disease Study J Orthop Translat. 2022, Jan.

27. Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Huiling Cao*, Zengwu Shao*, Guozhi Xiao*. Kindlin-2 inhibits NLRP3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res., Jan 10, 2022, 10 (5). Doi: 10.1038/s41413-021-00179-5

28. Xiaohao Wu, Yumei Lai, Sheng Chen, Chunlei Zhou, Chu Tao, Xuekun Fu, Jun Li, Jian Huang, Wei Tong, Hongtao Tian, Zengwu Shao, Chuanju Liu, Di Chen, Xiaochun Bai*, Huiling Cao*, Guozhi Xiao*. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nature Aging, Feb 10, 2022. https://doi.org/10.1038/s43587-021-00165-w

29. Lei Qin1#, Nian Liu1#, Chaolemeng Bao2#, Dazhi Yang1, Guixing Ma3, Weihong Yi1*, Guozhi Xiao3*, Huiling Cao3*, Mesenchymal Stem Cells in Fibrotic Diseases – the two sides of the same coin. Acta Pharmacologica Sinica (2022) 0:1–20; https://doi.org/10.1038/s41401-022-00952-0

30. Sorour Sadeghzade, Jingyi Liu, Huiru Wang, Xin Li, Jinrui Cao, Huiling Cao, BinTang, Hongyan Yuan. Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review). Materials Today Bio, Oct 25, 2022. https://doi.org/10.1016/j.mtbio.2022.100473

31. Huanqing Gao1#, Liang Zhou2#, Yiming Zhong1#, Zhen Ding1#, Sixiong Lin1,3, Xiaoting Hou1, Xiaoqian Zhou4, Jie Shao5, Fan Yang5, Xuenong Zou3, Huiling Cao1*, Guozhi Xiao1*, Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice, Nat Commun, Feb 23, 13:1025 | https://doi.org/10.1038/s41467-022-28692-z.

32. Zhengwei Liu1#, Wanze Tang1#, Jiayi Liu2#, Yingying Han1, Qinnan Yan1, Yuechao Dong1, Xiaomei Liu1a, Dazhi Yang3, Guixing Ma1*, Huiling Cao1*, A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound. Bioact Mater, volume 20, February 2023, Pages 610-626. https://doi.org/10.1016/j.bioactmat.2022.06.008

33. Huanqing Gao#, Yiming Zhong#, Liang Zhou#, Sixiong Lin#, Xiaoting Hou#, Zhen Ding, Yan Li, Qing Yao, Huiling Cao, Xuenong Zou, Di Chen, Xiaochun Bai, Guozhi Xiao. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. 2023 Jan 9;12:e81792. doi: 10.7554/eLife.81792.

34. Wanze Tang1#, Zhen Ding1#, Huanqing Gao1#, Qinnan Yan1#, Jingping Liu2, Yingying Han1, Xiaoting Hou1, Zhengwei Liu1, Litong Chen1, Dazhi Yang1*, Guixing Ma1*, Huiling Cao1*, Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting Fas/PPARγ/Fabp4 signaling in mice. Acta Pharmaceutica Sinica B. Jul 07, 2023. https://doi.org/10.1016/j.apsb.2023.07.001.

35. Yuechao DONG1#, Yangshan CHEN1#, Guixing MA1, Huiling CAO1*. The role of E3 ubiquitin ligases in bone homeostasis and related diseases. Acta Pharmaceutica Sinica B. Jul 06, 2023.  doi: 10.1016/j.apsb.2023.06.016.

36. Yuechao DONG1#, Xiaoting HOU1#, Yingying HAN1, Zhen DING1, Wanze TANG1, Yangshan CHEN1, Kaosheng Lv1, Guixing Ma1* and Huiling CAO1*. Kindlin-2 controls angiogenesis through modulating Notch1 signaling.Cell Mol Life Sci. October 2023. 13(10): 3963-3987.  doi: 10.1016/j.apsb.2023.06.016.

37. Xiaoting Hou1#, Yangshan Chen1#, Bo Zhou1, Wanze Tang1,1a, Zhen Ding1, Litong Chen1, Wei Pang1, Yun Wu2, Hongyu Yang2, Changzheng Du1, Dazhi Yang1a, Guixing Ma1*, and Huiling Cao1*. Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice.  Cell Death & Disease, Oct 31, 2023. 14 (10) Pages 709-723, DOI: 10.1038/s41419-023-06235-8.

38. Tailin He1#, Bo Zhou1#, Guohuan Sun2#, Qinnan Yan1, Sixiong Lin3, Guixing Ma1, Qing Yao1, Xiaohao Wu1, Yiming Zhong1, Donghao Gan1, Shaochuan Huo4, Wenfei Jin5, Di Chen6, Xiaochun Bai7*, Tao Cheng2*, Huiling Cao1*, Guozhi Xiao1*. The bone-liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway. Cell Death & Differentiation. 2023 Dec 07. doi: 1038/s41418-023-01243-9.

39. Yun Wu, Huan Jing, Yicun Li, Mengqing Li, yating Zheng, Yuntao Lin, Guixing Ma, Huiling Cao*, Hongyu Yang*. NOR1 promotes the osteoblastic differentiation of human periodontal ligament stem cells via TGF-β signaling pathway. Cell Mol Life Sci.2024 Aug 9;81(1):338.

40. Yong Chen, Botao Guo, Guixing Ma*, Huiling Cao*. Sensory nerve regulation of bone homeostasis: emerging therapeutic opportunities for bone-related diseases. Ageing Res Rev. 2024 Jun 14:102372. doi: 10.1016/j.arr.2024.102372.

41. Zhen Ding#, Guixing Ma#*, Bo Zhou, Siyuan Cheng, Wanze Tang, Yingying Han, Litong Chen, Wei Pang, Yangshan Chen, Dazhi Yang, Huiling Cao*. Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells. Cell Reports Medicine. 2024 Aug 20;5(8):101665.

42. Guixing Ma1#*, Yingying Han1#, Wanze Tang1a, Bo Zhou1, Litong Chen1, Zhen Ding1, Siyuan Cheng1, Di Chen2*, Huiling Cao1*.Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis.Protein & cell. 2024 Dec 2:pwae066. doi: 10.1093/procel/pwae066.

43. Guixing Ma#, Siyuan Cheng#, Yingying Han#, Wanze Tang, Wei Pang, Litong Chen, Zhen Ding, Huiling Cao1*.The p53-miR17 family-Rankl axis bridges liver-bone communication. Molecular Therapy. Accepted.

发明专利:

1. 专利号：ZL 2017 1 0180991.X，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗糖尿病的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-04-28，公告（公开）日期：2017-09-01。

2. 专利号：ZL 2017 1 0169753.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗肾炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。

3. 专利号：ZL 2017 1 0170718.9，发明专利，名称：Kindlin-2蛋白作为靶点在制备治疗骨性关节炎的药物中的应用，发明人：肖国芝，曹惠玲，授权日期：2020-07-31，公告（公开）日期：2017-09-08。

4. 专利申请号：2021101129689，发明专利，名称：抑制肝细胞中Kindlin-2蛋白表达量的试剂在制备治疗脂肪肝产品中的应用，发明人：肖国芝，曹惠玲，高焕庆，实审阶段，申请日期：2021/1/27。

5. 专利申请号：202210513385.6，发明专利，名称：一种水凝胶喷雾及其制备方法与应用，发明人：曹惠玲，马贵兴，刘正伟，实审，申请日期：2022/05/12。

6. 专利号：ZL 2022 1 1211629.1，Kindlin-2作为靶点在皮肤创伤修复中的应用，发明人：曹惠玲，马贵兴，申请日期：2022-09-30，授权公告日：2023-12-01。

7. 专利申请号：202210877899X，Kindlin-2作为靶点在治疗骨质疏松及预防癌症骨转移中的应用，发明人：曹惠玲，马贵兴，实审阶段，申请日期：2022/07/25。

8. 专利申请号：4，抑制脂肪细胞中 Kindlin-2 蛋白表达的试剂在制备治疗关节炎产品中的应用，发明人：曹惠玲，马贵兴，实审阶段，公告（公开）日期：2023-07-21。

联系方式

深圳市南山区西丽学苑大道1088号南方科技大学 慧园5栋205邮编：518055
电子邮件：caohl@sustech.edu.cn