个人简介

陈放怡副教授，1997年和2000年在清华大学生物医学工程专业分获学士和硕士学位。2005年获波士顿大学电气与计算机工程博士学位。2005年至2012年间在俄勒冈听觉研究中心从事研究助理和研究工程师工作。入选国家特聘专家青年计划。2012年至今在南方科技大学任副教授，陈放怡教授多年来主要从事听觉和前庭生理研究。研究方向包括模式动物听觉和前庭功能评价、临床用移动式听觉/平衡测试系统的研制和动物行为学自动识别等。研究结果发表于Nature Neuroscience, Journal of Neuroscience, Behavioural Brain Research等期刊。

针对目前国际上斑马鱼和小鼠前庭功能测试方法粗糙，研制了以前庭眼动为基本检测参数的斑马鱼和小鼠前庭功能测试系统，能够对前庭半规管和耳石器官损伤进行自动量化的精细评价。研制的科研仪器为Stanford University, University of Virginia, Creighton University, 清华大学等科研机构采用。

教育背景
1992-1997 清华大学生物医学工程 学士
1997-2000 清华大学生物医学工程 硕士
2000-2005 波士顿大学电气及计算机工程 博士

工作经历
2012-现在 南方科技大学 副教授
2009-2012 俄勒冈健康科学大学 研究助理/工程师
2008-2009 KLA-Tencor 公司 高级系统设计工程师
2006-2008 俄勒冈健康科学大学 研究助理/工程师
2005-2006 俄勒冈健康科学大学 博士后

主要发表文章

1. Lian Liu , Linzhi Zou , Kuan Li , Hanqing Hou , Qun Hu , Shuang Liu , Jie Li , Chenmeng Song , Jiaofeng Chen , Shufeng Wang , Yangzhen Wang , Changri Li , Haibo Du , Jun-Liszt Li , Fangyi Chen , Zhigang Xu , Wenzhi Sun , Qianwen Sun , Wei Xiong “Template-independent genome editing in the Pcdh15 av-3j mouse, a model of human DFNB23 nonsyndromic deafness”Cell Reports,July 12, 2022

2. Guanyun Wei, Xu Zhang, Chengyun Cai, Jiajing Sheng, Mengting Xu,Cheng Wang, Qiuxiang Gu, Chao Guo, Fangyi Chen, Dong Liu and Fuping Qian“Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway”Frontiers in Cellular Neuroscience，vol.16,Mar. 2022

3. Weitao Jiang, Zihan Wang, Shijie Xiao, Dingxuan Zeng, Zhuli Wu, Cheng Peng, and Fangyi Chen “Pulsed infrared radiation stimulation evoked compound potential in mouse vestibular system”  Neuroscience Letters.vol.775,1 April 2022.136510

4. Wu JP, Yang X, Wang Y, Swift B, Adamson R, Zheng Y, Zhang R, Zhong W, Chen F. “High Resolution and Labeling Free Studying the 3D Microstructure of the Pars Tensa-Annulus Unit of Mice.” Front Cell Dev Biol.vol.9, 8 Oct 2021 ;

5. Yan Zhang, Yanfei Wang, Xuebo Yao, Changquan Wang, Fangyi Chen, Dong Liu, Ming Shao*, Zhigang Xu*. Rbm24a is necessary for hair cell development through regulating mRNA stability in zebrafish.Front. Cell Dev. Biol., 17 December 2020.

6. Yuan Zhang, Shasha Zhang, Zhonghong Zhang, Ying Dong, Xiangyu Ma, Ruiying Qiang, Yin Chen, Xia Gao, Chunjie Zhao, Fangyi Chen, Shuangba He*, and Renjie Chai*. Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle.Aging.vol. 12, no. 20,31 October 2020.

7. Xinfeng Du, Jingying Zhai, Dingxuan Zeng, Fangyi Chen*,  Xiaojiang Xie*. Distance-based detection of calcium ions with hydrogels entrapping exhaustive ion-selective nanoparticles. Sensors and Actuators B: Chemical.Volume 319, 15 September 2020.

8. Shan Zeng, et.al., Fangyi Chen, Huawei Li, Yunfeng Wang*, Yan Chen*, and Wenyan Li*. Toxic Effects of 3,3'-Iminodipropionitrile on Vestibular System in Adult C57BL/6J Mice In Vivo. Neural Plasticity, vol. 2020.

Cuixia Guo, Zhiyuan Shen, Yanyan Suo, et.al,Yanhong Ji, Yonghong He*, Fangyi Chen*.Spectral-Domain Phase Microscopy for Thickness Encoded Suspension Array. IEEE Photonics Technology Letters vol. 32, no. 8, 15 April15, 2020.

9. Wenlu Pan, Kexin Lyu, Hongzheng Zhang, Cuixian Li, et.al, Fangyi Chen*, Jie Tang*. Attenuation of auditory mismatch negativity in serotonin transporter knockout mice with anxiety-related behaviors. Behavioural Brain Research vol. 379, 3 February 2020.

10. Xiaojie Yang, Peng Sun, Jian-Ping Wu,Weitao Jiang, et.al, Fangyi Chen*. Nondestructive and objective assessment of the vestibular functionin rodent models: A review. Neuroscience Letters vol. 717, 19 January 2020.

Rebecca Boyanich,Thomas Becker, Fangyi Chen, et.al. Application of Confocal, SHG and Atomic Force Microscopyfor Characterising the Structure of the Most Superficial Layer of Articular Cartilage. Journal of Microscopy, 10 July 2019.

11. Cuixia Guo,Xiaojie,Yang, et.al, Yonghong He*,et.al,Zhan Sun,Tian Guan,Fangyi Chen*.Image-guided vibrometry system integrated with spectral- and time-domain optical coherence tomography. Applied Optics. vol. 58, no. 7 , 1 March 2019.

12. Xiaojie Yang, Shiyue Zhou, Jiaojiao Wu, et. al,Wei Xiong,Shi Chen, Fangyi Chen*.Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function. Neuroscience Letters, vol. 696, 23 March 2019.

13. Qiaojun Fang, Yuhua Zhang, Peng Da, et. al,  Kaiming Su*, Renjie Chai*, Fangyi Chen*. Deletion of limk1 and limk2 in mice does not alter cochlear development or auditory function. Scientific Reports, 4 March 2019. 

14. Cuixia Guo, Xiaojie Yang, Zhiyuan Shen,et. al, Yonghong He*, Tian Guan ,Fangyi Chen*. A Fluidic Biosensor Based on a Phase-Sensitive Low-Coherence Spectral-Domain Interferometer. Sensors. 3 November 2018. 

15. Shanshan Han#, Xiliang Liu#, Shanglun Xie ,et. al, Daji Luo*, Fangyi Chen*,Mugen Liu*. Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy. Human Genetics, 21 September 2018.

16. Fangyi Chen*, Dingjun Zha*, Xiaojie Yang, Allyn Hubbard, & Alfred Nuttall. Hydromechanical structure of the cochlea supports the backward traveling wave in the cochleain vivo. Neural Plasticity 17 July 2018.

17. Peng Sun , Yingla Zhang , Feng Zhao,et. al, Mang I. Vai* , Dong Liu* , & Fangyi Chen*. An Assay for Systematically Quantifying the Vestibulo-Ocular Reflex to Assess Vestibular Function in Zebrafish Larvae. Frontiers in Cellular Neuroscience vol.12 :256, 21 August 2018. 

18. Ying Sun, Yanyan Jia, Yifeng  Guo, Fangyi Chen*, Zhiqiang Yan*. Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila. Neuroscience bulletin 24 July 2018. 

19. Q. H. He, D. M. Li, Y. H. He* ,et. al, X. J. Chen, S. Y. Liu ,& F. Y. Chen*.Microbeads preparation with reversed-phase microemulsion and ultraviolet light curing for digital encoding suspension array. RSC Advances, 21 June 2017

20. Cheng Cheng, Luo Guo, et, al,Fangyi Chen, Haibo Shi*, Huawei Li*, Renjie Chai*. Characterization of the transcriptomes of Lgr5+ hair cell progenitors and Lgr5−supporting cells in the mouse cochlea. Frontiers in Molecular Neuroscience. 26 April 2017

21. Qin Yang, Peng Sun, Shi Chen, Hongzhe Li*,Fangyi Chen*.Behavioral methods for the functional assessment of hair cells in zebrafish, Frontiers of Medicine, 27 March,2017 

22. Changquan Wang, Zhenmin Zhong,  Peng Sun, Hanbing Zhong*, Hongzhe Li*, & Fangyi Chen*, Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses. Neural Plasticity ,29 January, 2017.

23. Taiping Zeng, Zhiping Zhang, Weiwei Peng, Fei Zhang, Baker Y. Shi, Fangyi Chen*, Unilateral Laryngeal Pacing System and Its Functional Evaluation, Neural Plasticity, 19 January, 2017. 

24. Sara G. Shen*, Fangyi Chen, David E. Schoppik, & David M. Checkley Jr. Otolith size and the vestibulo-ocular reflex of larvae of white seabass Atractoscion nobilis at high pCO2. Marine Ecology Progress Series, July 14 ,2016

25. Tao Wu, Sripriya Ramamoorthy, Teresa Wilson, Fangyi Chen, et. al, John V. Brigande, Zhi-Gen Jiang, Tianyi Mao, Alfred L. Nuttall, Optogenetic Control of Mouse Outer Hair Cells, Biophysical Journal, vol. 110, no. 2, 19 January 2016

26. Yuqin Yang, Fangyi Chen, Takatoshi Karasawa, Ke-Tao Ma, Bing-Cai Guan, Xiao-Rui Shi, Hongzhe Li, Peter S. Steyger1, Alfred L. Nuttall1 and Zhi-Gen Jiang, Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles. PLOS one, 4 May 2015. 

27. Ramamoorthy S, Zha D, Chen F, Jacques SL, Wang R, Choudhury N, Nuttall AL, Fridberger A.  Filtering of acoustic signals within the hearing organ.  Journal of  Neuroscience, 2 July 2014;34(27) (equally contributed)

28. Subhash HM, Choudhury N, Chen F, Wang RK, Jacques SL, Nuttall AL. Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry. Journal of Biomedical Optics, 2013;18(3).

29. Zha D, Chen F*, Ramamoorthy S, Fridberger A, Choudhury N, et al. “ In Vivo Outer Hair Cell Length Changes Expose the Active Process in the Cochlea.” PLoS one, 2012; 7(4). 

30. Chen F, Zha D, Fridberger A, Zheng J, Choudhury N, Jacques SL, Wang RK, Shi X, Nuttall AL.  “A differentially amplified motion in the ear for near-threshold sound detection.”  Nature Neuroscience, June 2011. v14: 770-775.

31. Zheng J, Ramamoorthy S, Ren T, He W, Zha D, Chen F, Magnusson A, Nuttall AL, Fridberger A. “Persistence of past stimulations: storing sounds within the inner ear.” Biophysical Journal, 6 Apr 2011.

32. Mo W., Chen F., Nechiporuk A. and Nicolson T.  “Quantification of vestibular-induced eye movements in zebrafish larvae.”  BMC Neuroscience, 11:110 2010, (equally contributed)

33. Choudhury, N., Chen, F., Zheng, J., Nuttall, A.L., and Wang, R.K. “Volumetric imaging of blood flow within cochlea in gerbil in vivo.” IEEE J Sel Top Quantum Electron, 20 Oct 2009

34. Chen, F. and Nuttall, A. “Comment on “Measuring power production in the mammalian cochlea” [Curr. Biol. 17, 1340 (2007)] (L)” Journal of Acoustic Society of America, vol. 125, no.1, 2009

35. Chen, F., Choudhury, N., Zheng, J., Matthews, S., Nuttall, A. and Jacques, S. “In vivo imaging and low-coherence interferometry of cochlear membrane vibration” Journal of Biomedical Optics, vol. 12, no. 2. 2007

36. Chen, F., Cohen, H., Kapusta, C., Fortin, J., Bifano, T., Mountain, D., Zosuls, A., and Hubbard, A.  “A hydro-mechanical biomimetic cochlea: Experiments and models” Journal of Acoustic Society of America, vol. 119, no. 1, 2006

37. Choudhury, N., Song, G., Chen, F., Matthews, S., Tschinkel, T., Zheng, J., Jacques, S., and Nuttall, A.L. “Low  coherence interferometry of cochlear partition,” Hearing Research, vol. 220, 2006