个人简介：

杜嘉木教授2003年本科毕业于复旦大学，2008年博士毕业于中科院上海生化细胞所，2009年赴美在纽约纪念斯隆凯特琳癌症中心开始博士后研究；2014年回国，在中国科学院上海生命科学研究院植物逆境生物学研究中心组建独立实验室，任研究员、课题组长、博士生导师；2019年2月调动至南方科技大学生物系任教授、课题组长、博士生导师。2016年获基金委优秀青年科学基金的支持；2020年获中国植物生理与植物分子生物学学会卫志明青年创新奖；2022年获中国植物生理与植物分子生物学学会杰出青年科学家奖；2023年获基金委杰出青年科学基金支持。杜嘉木教授长期从事植物基因调控，特别是植物表观遗传调控的分子机制研究，在多个领域做出了杰出的贡献，迄今共发表SCI论文67篇，其中多篇以通讯及共同通讯作者身份发表在Science、Nature Genetics、Nature Plants、Nature Chemical Biology、Nature Communications、Plant Cell、PNAS、J Integr Plant Biol等国际顶尖学术杂志上。

教育经历：

• 2003/09 – 2008/07，生物化学与分子生物学，博士

中国科学院上海生命科学研究院上海生物化学与细胞生物学研究所

（导师：丁建平研究员）

• 1999/09 –2003/07 生物学，学士 ，中国上海复旦大学

工作经历：

• 2019/02 – 至今，教授，南方科技大学生命科学学院生物系

• 2017/10 – 2019/01，青年研究骨干，中国科学院分子植物卓越创新研究中心；植物分子遗传国家重点实验室

• 2014/09 – 2019/01，研究员，中国科学院上海生命科学研究院上海植物逆境生物学研究中心

• 2009/10 – 2014/08，博士后，纪念斯隆凯特琳癌症中心（研究导师: Dinshaw J. Patel院士）

• 2008/07 – 2009/09，助理研究员，中国科学院上海生命科学研究院上海生物化学与细胞生物学研究所

荣誉及奖励：

• 2023年，国家自然科学基金委杰出青年科学基金

• 2022年，中国植物生理与植物分子生物学学会杰出青年科学家奖

• 2022年，南方科技大学校长杰出科研奖

• 2022年，南方科技大学优秀研究生导师奖

• 2020年，中国植物生理与植物分子生物学学会卫志明青年创新奖

• 2020年，中国科学院大学领雁银奖

• 2019年，中国科学院优秀导师奖

• 2018年，中国科学院优秀导师奖

• 2017年，国家自然科学基金委优秀青年科学基金

• 2016年，科技部国家重点研发计划项目首席科学家（青年）

杂志编辑

2018 – 至今，Biochemical Society Transactions，副编辑

杂志审稿人：

• Journal of Molecular Medicine  • PLoS One • PNAS  • New Phytologist

• Trends in Plant Science   • Plant Cell • Structure  • Molecular Plant

• Critical Reviews in Biochemistry & Molecular Biology • Nature Communications

• Biochemistry and Biophysics Reports      •Journal of Molecular Biology

• Epigenetics & Chromatin

基金评审:

2018年，国家自然科学基金委青年项目、面上项目、地区科学基金项目

2017-2018年，中国博士后科学基金

代表文章：

(1) Xie, G#, Du, X#, Hu, H#, Li, S, Cao, X, Jacobsen, S.E, and Du, J. Structure and mechanism of the plant RNA polymerase V. Science. 2023, adf8231.

(2) Du X, Yang Z, Xie G, Wang C, Zhang L, Yan K, Yang M, Li S, Zhu JK, Du J. Molecular basis of the plant ROS1-mediated active DNA demethylation. Nat Plants. 2023, 9: 271-279.

(3) Zhang J#, Yuan J#, Lin J#, Chen L, You LY, Chen S, Peng L, Wang CH, Du J*, Duan CG*. Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants. Proc Natl Acad Sci U S A. 2023, 120: e2208525120.

(4) Leichter SM, Du J, Zhong X. Structure and Mechanism of Plant DNA Methyltransferases. Adv Exp Med Biol. 2022, 1389: 137-157.

(5) Zhou X#, Wei M#, Nie W#, Xi Y, Peng L, Zheng Q, Tang K, Satheesh V, Wang Y, Luo J, Du X, Liu R, Yang Z, La H, Zhong Y, Yang Y, Zhu JK, Du J*, Lei M*.The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. J Integr Plant Biol. 2022, 64: 2385-2395.

(6) Du J*, Patel DJ*. Cofactor-assisted dicing: insights from structural snapshots. Cell Res. 2022 32: 965-966.

(7) Li S*, Du J*. Making a 6mA demethylase. Nat Chem Biol. 2022, 18: 683-684.

(8) Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris JC, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. A SYBR Gold-based Label-free in vitro Dicing Assay. Bio Protoc. 2022, 12: e4382.

(9) Hu H, Du J*. Structure and mechanism of histone methylation dynamics in Arabidopsis. Curr Opin Plant Biol. 2022, 67:102211.

(10) Du X#, Yang Z#, Ariza AJF, Wang Q, Xie G, Li S, Du J*. Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. Plant Cell. 2022, 34: 2140-2149. 

(11) Zeng X#, Lv X#, Liu R, He H, Liang S, Chen L, Zhang F, Chen L, He Y*, Du J*. Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation. J Integr Plant Biol. 2022, 64: 731-740.

(12) Wang Q#, Xue Y#, Zhang L#, Zhong Z, Feng S, Wang C, Xiao L, Yang Z, Harris CJ, Wu Z, Zhai J, Yang M, Li S*, Jacobsen SE*, Du J*. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021, 374: 1152-1157

(13) Hu H#, Tian S#, Xie G, Liu R, Wang N, Li S, He Y*, Du J*. TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis. Proc Natl Acad Sci U S A. 2021, 118: e2103895118

(14) Wang Y#, Zhou X#, Luo J, Lv S, Liu R, Du X, Jia B, Yuan F, Zhang H, Du J*. Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2. J Integr Plant Biol. 2021, 63: 1091-1096. 

(15) Niu Q#, Song Z#, Tang K, Chen L, Wang L, Ban T, Guo Z, Kim C, Zhang H, Duan CG, Zhang H, Zhu JK, Du J*, Lang Z*. A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation. Nat Commun. 2021, 12: 3367. 

(16) Lv X, Zeng X, Hu H, Chen L, Zhang F, Liu R, Liu Y, Zhou X, Wang C, Wu Z, Kim C, He Y, Du J*. Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex. Plant Cell. 2021, 33: 1182-1195. 

(17) Zhang YZ#, Yuan J#, Zhang L#, Chen C, Wang Y, Zhang G, Peng L, Xie SS, Jiang J, Zhu JK*, Du J*, Duan CG*.. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Nat Commun. 2020, 11: 6212. 

(18) Tan LM#, Liu R#, Gu BW, Zhang CJ, Luo J, Guo J, Wang Y, Chen L, Du X, Li S, Shao CR, Su YN, Cai XW, Lin RN, Li L, Chen S, Du J*, He XJ*. Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell. 2020, 32: 2178-2195.

(19) Tao Z#, Hu H#, Luo X#, Jia B, Du J*, He Y*. Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants 2019, 5: 424-435.

(20) Zheng S, Hu H, Ren H, Yang Z, Qiu Q, Qi W, Liu X, Chen X, Cui X, Li S, Zhou B, Sun D*, Cao X*, Du J*. The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun. 2019 10: 1303.

(21) Harris CJ#, Scheibe M#, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F*, Jacobsen SE*. A DNA methylation reader complex that enhances gene transcription. Science 2018; 362: 1182-1186.

(22) Zhang C#, Du X#, Tang K#, Yang Z, Pan L, Zhu P, Luo J, Jiang Y, Zhang H, Wan H, Wang X, Wu F, Tao WA, He XJ, Zhang H, Bressan RA, Du J*, Zhu JK*. Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin. Nat Commun. 2018b; 9: 4547. (* co-corresponding authors)

(23) Li X#, Harris CJ#, Zhong Z, Chen W, Liu R, Jia B, Wang Z, Li S, Jacobsen SE*, Du J*. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context biased non-CG DNA methylation. Proc Natl Acad Sci U S A. 2018; 115: E8793-E8802. (* co-corresponding authors)

(24) Yang Z#, Qian S#, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J*, Zhong X*. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat Genet. 2018; 50: 1247-1253. (* co-corresponding authors)

(25) Qian S#, Lv X#, Scheid RN#, Lu L, Yang Z, Chen W, Liu R, Boersma MD, Denu JM, Zhong X*, Du J*. Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun. 2018; 9: 2425. (* co-corresponding authors)

(26) Yang Z, Qiu Q, Chen W, Jia B, Chen X, Hu H, He K, Deng X, Li S, Tao WA, Cao X*, Du J*. Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell. 2018; 30: 167-177. (* co-corresponding authors)

(27) Liu R#, Li X#, Chen W, Du J*. Structure and mechanism of plant histone mark readers. Sci China Life Sci. 2018; 61: 170-177. Review Article.

(28) Du J*. Structure and Mechanism of Plant DNA Methyltransferases. Adv Exp Med Biol. 2016; 945: 173-92. Book Chapter.

(29) Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J, He Y. A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nat Genet. 2016; 48:1527-34

(30) Li S, Yang Z, Du X, Liu R, Wilkinson AW, Gozani O, Jacobsen SE, Patel DJ, Du J*. Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Structure. 2016; 24: 486-94

(31) Du J#, Johnson LM#, Jacobsen SE, Patel DJ. DNA methylation pathways and their crosstalk with histone methylation. Nat Rev Mol Cell Biol. 2015; 1839: 519-32. (# co-first authors) Review Article

(32) Du J*, Patel DJ*. Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (Gene Regulatory Mechanisms). 2014; 1839:719-27. (* co-corresponding authors) Review Article

(33) Du J#, Johnson LM#, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol Cell. 2014; 55, 495–504. (# co-first authors)

(34) Zhong X#, Du J#, Hale CJ, Gallego-Bartolome J, Feng S, Vashisht AA, Chory J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell. 2014; 157: 1050-60. (# co-first authors)

(35) Johnson LM#, Du J#, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014; 507: 124-8. (# co-first authors)

(36) Stroud H, Do T, Du J, Zhong X, Feng S, Johnson L, Patel DJ, Jacobsen SE. Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat Struct Mol Biol. 2014; 21: 64-72.

(37) Law JA#, Du J#, Hale CJ#, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE. Polymerase-IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 2013; 498: 385-89. (# co-first authors)

(38) Du J#, Zhong X#, Bernatavichute YV, Stroud H, Feng S, Caro E, Vashisht AA, Terragni J, Chin HG, Tu A, Hetzel J, Wohlschlegel JA, Pradhan S, Patel DJ, Jacobsen SE. Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell. 2012; 151:167-80. (# co-first authors)