师资

谭斌
讲席教授
科研副系主任
0755-88018315
tanb@sustech.edu.cn

谭斌是南方科技大学终身教授,化学系科研副主任、博士生导师。2001年本科毕业于湖南科技大学。2005年硕士毕业于厦门大学化学系。 2010年博士毕业于新加坡南洋理工大学化学与生物化学系,导师钟国富教授,研究方向为新型手性有机催化剂的设计及不对称多米诺反应的研究。2010年3月至2012 年9月的博士后期间,在有机小分子催化领域的发源地--美国斯克普斯研究所 (The Scripps Research Institute)师从Barbas教授,继续从事催化不对称合成的研究。2012年9月,以准聘(Tenure-Track)副教授身份加入南方科技大学化学系。2018年1月晋升为终身正教授。

到目前为止,在轴手性化学、不对称多组分反应、自由基化学以及协同催化领域发表高水平研究论文60多篇,其中包括以第一作者或通讯作者身份发表的1篇Science、2篇Nature Chemistry、3篇Nature Communications、 6篇J. Am. Chem. Soc.、11篇Angew. Chem. Int. Ed. 和1篇Accounts of Chemical Research,论文总被引超过4000次。多篇论文被多篇文章被不同国际杂志重点评述或被选为封面文章。此外还有多篇高水平研究论文正在审稿和准备之中。

目前担任《中国科学-化学》和《中国化学》青年编委。

 

研究领域及方向

◆ 核心骨架结构导向的催化不对称合成    ◆现代催化体系和绿色合成新方法的开发
◆ 金属与有机催化协同的催化体系应用    ◆手性药物的开发和天然产物策略全合成

 

教育研究背景:

◆ 2010年3月-2012年09月,博士后,      美国斯克普斯研究所 (TSRI)
(导师:Carlos F. Barbas III教授)
◆ 2006年1月-2010年01月,博士研究生,   新加坡南洋理工大学(NTU)
(导师:钟国富教授)
◆ 2002年9月-2005年11月,硕士研究生,   厦门大学 (XMU)
(导师:靳立人教授)

工作经历:

2012.9-至今 南方科技大学化学系

 

所获荣誉:

◆ 2013年,深圳市海外高层次人才“孔雀计划”B类入选者
◆ 2009年,国家优秀自费留学生奖学金

 

代表性研究成果:(独立工作以前,只列第一作者,所有文章的影响因子都大于5.5)

1. Tan, B.; Candeias, N.; Barbas III, C.R. Construction of Bispirooxindoles Containing three Quaternary Stereocentres in a Cascade Using a Single Multifunctional Organocatalyst. Nature Chem. 2011, 3, 473-477.
2. Tan. B.; Toda N; Barbas III, C. F. Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-coupling Strategy. Angew. Chem. Int. Ed. 2012, 51, 12538-12541.
3. Tan. B.; Hernández-Torres, G.; Barbas III, C. F. Rational Design Enables Amide Nucleophiles for Organocatalytic Asymmetric Michael Reactions. Angew. Chem. Int. Ed. 2012, 51, 5381-5385.
4. Tan B.; Hernández-Torres, G.; Barbas III, C.F. Highly Efficient Hydrogen-Bonding Catalysis of the Diels-Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeleton. J. Am. Chem. Soc. 2011, 131, 12354-12358.
5. Tan, B.; Candeias, N.; Barbas III, C.F. J. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. J. Am. Chem. Soc. 2011, 131, 4672-4675.
6. Tan, B.; Shi. Z.; Chua, P. J.; Li, Y.; Zhong, G. Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles. Angew. Chem. Int. Ed. 2009, 48, 758-761.
7. Tan, B.; Zeng, X.; Chua, P. J.; Zhong, G. Rational Design of Domino Michael-Henry Reaction: Direct Construction of Bicyclo[3.2.1]octane Skeletons with Four Stereogeric Centers. Org. Lett. 2010, 12, 2682-2685.
8. Tan, B.; Zhu, D.; Zhang, L.; Dai, L.; Chua, P. J.; Shi, Z.; Zeng, X; Zhong, G. Water More than Just a Green Solvent: A Stereoselective One-Pot Access to All Chiral Tetrahydronaphthalenes in Aqueous Media. Chem. Eur. J. 2010, 16, 3842-3848.
9. Tan, B.; Zeng, X.; Leong, W. W. Y.; Shi, Z.; Barbas III, C.F.; Zhong, G. Core Structure-Based Design of a Novel Organocatalytic [3+2] Cycloaddition: Highly efficient and Stereocontrolled Synthesis of Spirocyclic Oxindoles. Chem. Eur. J. 2012, 18, 63-67.
10. Tan, B.; Zhang, X.; Chua, P. J.; Zhong, G. Recyclable organocatalysis: highly enantioselective Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins (Cover Article). Chem. Commun. 2009, 779-781
11. Tan, B.; Zeng, X.; Lu, Y.; Chua, P. J.; Zhong, G. Rational Design of Organocatalyst: Highly Stereoselective Michael Addition of Cyclic Ketones to Nitroolefins. Org. Lett. 2009, 11, 1931-1933.
12. Tan, B.; Chua, P. J.; Zeng, X.; Lu, M.; Zhong, G. A Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Cyclopentanes with Four Chiral Carbons by the Organocatalytic Domino Michael-Henry Reaction. Org. Lett. 2008, 10, 3489-3492.
13. Tan, B.; Shi, Z.; Chua, P. J.; Zhong, G. Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes. Org. Lett. 2008, 10, 3425-3428.
14. Tan, B.; Chua, P. J.; Li, Y.; Zhong, G. Organocatalytic Asymmetric Tandem Michael-Henry Reactions: A Highly Stereoselective Synthesis of Multifunctionalized Cyclohexanes with Two Quaternary Stereocenters. Org. Lett. 2008, 10, 2437-2440.

 

代表性研究成果:(独立工作以后从2013年7月至今)

1. Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan,* Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles. Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201504640.
2. Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*, Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation. Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201503207.
3. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*, Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of  Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.
4. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*,Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 2015, 54, 4041.
5. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*,and Xin-Yuan Liu* “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene”  Angew. Chem. Int. Ed. 2014, 53, 11890.
6. Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan* “Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid” Angew. Chem. Int. Ed. 2014, 53, 3684.
7. Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu*, Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 2015, 5, 2826.
8. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 2015, 17, 1589-1592.

9. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds. Chem. Eur. J. 2015, 21, 6718.

10. Lei Li, Jing-Yao Guo, Su Chen, Tao Wang, Bin Tan* and Xin-Yuan Liu* “Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation” Org. Lett., 2014, 16, 6032.

11. Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan* and Xin-Yuan Liu* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles” J. Org. Chem. 2014, 79, 7084.

12. Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu* and Bin Tan* “In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles” Org. Lett. 2014, 16, 2192.

13. Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu* “Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement” Org. Lett. 2014, 16, 1000.

14. Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan* and Xin-Yuan Liu.* “Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles” Org. Lett. 2014, 16, 504.

15. Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles” Chem. Eur. J. 2014, 20, 1332.

16. Dao-Juan Cheng, Yoshihiro Ishihara, Bin Tan* and Carlos F. Barbas, III* “Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies”
ACS Catal. 2014, 4, 743.

 

项目基金

1. 研究基金+广东省配套经费(250万);
2. 南方科技大学引进学术人才科研启动经费(620 + 100 万)
核心骨架结构导向的催化不对称合成;
3. 国家自然科学基金委青年面上项目(80万)
有机催化不对称合成联芳基轴手性化合物;
4. 国家自然科学基金委青年基金项目(25万)
不对称合成具有重要生物活性3,3′-四氢吡咯螺羟吲哚骨架结构;
5. 深圳市科技创新委员会基础研究项目(10万)
四氢吡咯螺羟吲哚衍生物的设计和催化不对称合成以及抗癌活性的研究;
6. 深圳市科技创新委员会基础研究项目(30万)
基于重氮吲哚酮的催化不对称合成及其产物的抗癌活性研究