个人简介：

牛锋锋博士，现为南方科技大学生命科学学院研究副教授，硕士生导师。本科毕业于南开大学，随后在中科院生物物理研究所获得生物化学与分子生物学专业博士学位。2016年加入南方科技大学，历任博士后，研究助理教授和研究副教授。主要利用生物化学、结构生物学及细胞生物学等手段，研究人体和病原体内生物大分子的结构与功能。近年来主要从事分子马达蛋白介导的胞内物质运输的分子机制研究。

研究领域：

结构生物学；细胞内物质运输。

工作经历：

2023 - 至今，南方科技大学，生命科学学院，研究副教授；

2019 - 2023，南方科技大学，生命科学学院/前沿与交叉科学研究院，研究助理教授；

2016 - 2019，南方科技大学，生物系，博士后。

学习经历：

2009 - 2015，中国科学院生物物理研究所，生物化学与分子生物学，博士；

2005 - 2009，南开大学，生命科学，学士。

代表文章：

1. Niu, F.*, Li, L.*, Wang, L., Xiao, J, Xu, S., Liu, Y., Lin, L., Yu, C.#, Wei, Z.#. Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat. Comm. 2024 Jan. (accepted)

2. Jia, X.*; Lin, L.*; Xu, S.; Li, L.; Wei, Z.; Yu, C.#; Niu, F.# Crystal Structure of the SH3 Domain of ASAP1 in Complex with the Proline Rich Motif (PRM) of MICAL1 Reveals a Unique SH3/PRM Interaction Mode. Int. J. Mol. Sci. 2023, 24, 1414. https://doi.org/10.3390/ijms24021414

3. Niu, F.*#, Liu, Y.*, Sun, K.*, Xu, S., Dong, J., Yu, C., Yan, K., Wei, Z#. Autoinhibition and Activation Mechanisms Revealed by the Triangular-shaped Structure of Myosin Va. Sci Adv. 2022 Dec 9;8(49):eadd4187. doi: 10.1126/sciadv.add4187. Epub 2022 Dec 9. PMID: 36490350.

4. Liu Y, Li L, Yu C, Zeng F, Niu F#, Wei Z#. Cargo Recognition Mechanisms of Yeast Myo2 Revealed by AlphaFold2-Powered Protein Complex Prediction. Biomolecules. 2022 Jul 26;12(8):1032. doi: 10.3390/biom12081032. PMID: 35892342; PMCID: PMC9330073.

5. Liang, M.*, Jin, G.*, Xie, X.*, Zhang, W., Li, K., Niu, F., Yu, C., Wei, Z. Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep. 2021 Mar 23;34(12):108901. doi: 10.1016/j.celrep.2021.108901. PMID: 33761347.

6. Niu, F.*, Sun, K.*, Wei, W., Yu, C., Wei, Z. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 2020 Nov 6;6(45):eabb1307. doi: 10.1126/sciadv.abb1307. PMID: 33158857; PMCID: PMC7673715.

7. Li, J. *, Rodriguez, J. P. *, Niu, F., Pu, M., Wang, J., Hung, L. W., … & Ouyang, S. (2016). Structural basis for DNA recognition by STAT6. Proceedings of the National Academy of Sciences, 113(46), 13015-13020.

8. Burakova, L. P., Natashin, P. V., Malikova, N. P., Niu, F., Pu, M., Vysotski, E. S., & Liu, Z. J. (2016). All Ca 2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin. Journal of Photochemistry and Photobiology B: Biology, 154, 57-66.

9. Jiao, L.*, Ouyang, S.*, Shaw, N., Song, G., Feng, Y., Niu, F., … & Liu, Z. J. (2014). Mechanism of the Rpn13-induced activation of Uch37. Protein & Cell, 1-15.

10. Gu, J., Feng, Y., Feng, X., Sun, C., Lei, L., Ding, W., Niu, F., … & Han, W. (2014). Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin. PLoS pathogens, 10(5), e1004109.

11. Niu, F.*, Shaw, N*., Wang, Y. E.*, Jiao, L.*, Ding, W., Li, X., … & Liu, Z. J. (2013). Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation. Proceedings of the National Academy of Sciences, 110(22), 9054-9059.

12. Jiao, L.*, Ouyang, S.*, Liang, M.*, Niu, F.*, Shaw, N., Wu, W., … & Liu, Z. J. (2013). Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. Journal of virology, 87(12), 6829-6839.

13. Niu, F., Ru, H., Ding, W., Ouyang, S., & Liu, Z. J. (2013). Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein & cell, 4(9), 687-694.

14. Ouyang, S.*, Song, X.*, Wang, Y.*, Ru, H.*, Shaw, N., Jiang, Y., Niu, F., … & Liu, Z. J. (2012). Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity, 36(6), 1073-1086.

    (*co-first author, #corresponding author)