个人简介

傅暘，博士，南方科技大学医学院生物化学系正高级研究员/长聘副教授，博士生导师，国家海外高层次青年人才，深圳市孔雀人才。现任南方科技大学生物安全平台副主任、冷冻电镜委员会委员。2013年获南开大学生物化学与分子生物学博士学位、哈佛大学医学院联合培养微生物学博士。师从世界著名微生物学家、美国科学院院士John Mekalanos教授。

本团队的科研工作方向可以总结为‘围绕一个核心，开拓一条新线’。一个核心：即变形菌门细菌的大分子跨膜递送系统相关蛋白和遗传元件的功能机制解析与应用研究；一条新线是指作为医学院早期少数的微生物领域PI，我们响应国家与学校号召开展的：新冠与猴痘病毒等新发突发传染病病原的应急攻关科学研究。聚焦在细菌大分子跨膜递送这个研究核心，我们以弧菌、假单胞菌、气单胞菌等细菌的II型、III型和VI型分泌系统及其效应蛋白研究对象，面向：1）精准抗菌机制与机理；2）致病性与宿主防御；3）相关应用技术，展开了深入而系列化研究。同时，通过前期在‘病原蛋白与宿主互作’领域的理论与技术积累，我们在新发病毒研究的这条辅线中，面向抗体与药物靶点研究，也已形成了自己的科研特色。目前傅暘团队累计发表研究论文37篇（南科大29篇)，其中入职前在Cell Host & Microbe、PNAS等杂志发表论文多篇，入职后以通讯作者（含共同）身份发表论文14篇，包括Mol Cell, Gut Microbes, J Biol Chem(2篇), Microbiol Res (2篇)，mLife, Virology, Allergy等，全部以南科大为本人唯一署名单位。论文总引超5620次。

本团队累计主持国家自然科学基金委面上项目和青年项目、深圳市科创委基础研发重点专项、深圳市科创委孔雀团队项目、深圳市抗疫应急攻关重点专项、深圳市医学科学院（SMART）等十余项项目。

学术任职

1、Bio-Protocol杂志编辑

2、Frontiers Cellular and Infection Microbiology专刊编辑

获奖荣誉

1、国家级人才头衔

2、深圳市人才头衔

3、Fogarty Global Health Fellowship

教育经历

1、2001.09-2005.06 江南大学，生物工程学专业学士

2、2006.09-2013.06 南开大学，生物化学与分子生物学专业博士

3、2009.09-2013.05 哈佛大学，微生物学与免疫生物学专业联培博士

工作经历：

1、2005.07-2006.08 南开大学，技术员

2、2008.06-2009.01 哈佛大学公共卫生学院，交换生

3、2013.07-2018.06 哈佛大学医学院，博士后研究员

4、2018.07-2019.06 哈佛大学医学院，助理研究员

5、2019.06-2020.12 南方科技大学，助理教授/博士生导师

6、2021.01-至今    南方科技大学，副教授/博士生导师

代表性论文：

* Contributed equally to the work and # for corresponding authors

Representative papers at SUSTech as a Corresponding author:

(1) Liu M, Wang H, Wang Z, Wang H, Zhang K, Xue J, Liu RH, Liu Y, Xia PY,  Wang H, Kan B, Li Y, Li S, Fu Y#. A Vibrio-specific T6SS effector reshapes microbial competition by disrupting Vibrio bioenergetics, a precision antimicrobial mechanism. Cell Host and Microbe. 2025, in press.

(2) Wang H, Liu Y, Wang Z, Xia P, Li Z, Liu M#, Fu Y#. Functional Insights into the Type VI Secretion System of Multi-drug Resistant Aeromonas hydrophila: A Key Factor in Competition and Pathogenesis. mLife. 2025, in press. DOI: 10.1002/mlf2.70018.

(3) Guo HH, Zhang Q, Wang Z, Zhang K#, Fu Y#. Structural insight into Vibrio cholerae EIIC Sugar Transporter Dimer Captured in a Substrate-Free Inward-facing State. Acta Biochimica et Biophysica Sinica. 2025, in press.

(4) Feng Q*, Dai, X, Wu, Q, Zhang L#, Yang L#, Fu Y#. C-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. mSphere. 2025; e01026-24.

(5) Yu B*, Lu Q*, Li J*, Cheng X*, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y#, Fu Y#, Zhang J#. Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J Biol Chem. 2024;300(6):107288.

(6) Xiang Q*, Wu J, Zhou Y, Li L, Tian M, Li G#, Zhang Z#, Fu Y#. SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. Microbiol Res. 2024; 282:127659.

(7) Feng Q*, Zhou J, Zhang L, Fu Y#, Yang L#. Insights into the molecular basis of c-diGMP signalling in Pseudomonas aeruginosa. Crit Rev Microbiol. 2024;50(1):20-38.

(8) Zhang Y*, Wang D*, Xiang Q*, Hu X, Zhang Y, Wu L, Zhang Z, Wang Y, Zhao J, McCormick PJ, Fu J#, Fu Y#, Zhang J#, Jiang H#, Li J#. A potent neutralizing nanobodytargeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology. 2024; 589:109925.

(9) Liu M*, Wang H*, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Wang H, Wang H, Fu Y#. The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression. Gut Microbes. 2023; 15(1): 2241204.

(10) Liu M*, Zhao MY*, Wang H, Wang ZH, Wang Z, Liu Y, Li YP, Dong T, Fu Y#. Pesticin-Like Effector VgrG3(cp) Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition. Microbiol Spectr. 2023; 11(1): e0426722.

(11) Zhang K*, Peng T*, Tao X*, Tian M*, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y#, Li S#. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022;82(24):4712-4726 e4717.

(12) Xiang Q, Li L, Wu J, Tian M, Fu Y#. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies. Microbiol Res. 2022; 258:126993. [JCR: Q1].

(13) Song X*, Li J*, Tian M*, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022;298(2):10148.

(14) Chen Y*, Wang S*, Huang J*, Fu Y, Wen J, Zhou C, Fu Y#, Liu L#. Application of extracorporeal carbon dioxide removal combined with continuous blood purification therapy in ARDS with hypercapnia in patients with critical COVID-19. Clin Hemorheol Microcirc. 2021; 78(2):199-207. [JCR: Q3].

(15) Cai Q*, Huang D*, Ou P*, Yu H, Zhu Z, Xia Z, Su Y, Ma Z, Zhang Y, Li Z, He Q, Liu L#, Fu Y#, Chen J#. COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020;75(7):1742-1752. [JCR: Q1].

Before joining SUSTech 

(16) Fu Y*, Ho BT*, Mekalanos JJ#. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host and Microbe. 2018; 23(2): 274-281 e272.

(17) Ho BT*, Fu Y*, Dong TG, Mekalanos JJ#. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci USA. 2017;114(35):9427-9432.

(18) Fu Y, Waldor MK, Mekalanos JJ#. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host and Microbe. 2013; 14(6): 652-663.