师资
个人简介：
洪鑫博士是南方科技大学医学院生物化学系助理教授(Tenure-track A/P)，副研究员，博士生导师，于2013年博士毕业于新加坡国立大学，2014-2020年博士后期间在哈佛医学院／霍华德医学研究中心 (HHMI) 致力于癌症转移生物学机制和循环肿瘤细胞（CTC）液体活检技术的研发，相关成果发表在 Cell、 Cancer Discovery、 PNAS、 EMBO Journal、 Genes & Development 等国际著名期刊，引用超过1700次 （H-index = 21）,并获得了多个国际和国内奖项和荣誉，包括新加坡国立大学最佳毕业生奖（Lijen Industrial Development Award, NUS), 新加坡科研局青年基金（A*STAR JCO early career development award）以及美国癌症协会 (AACR) 的青年学者奖项 （AACR Scholar-In-Training Award)。本课题组近3年获批主持/承担国家级项目5项，包括国家基金委外国优秀青年学者项目、面上/青年项目、以及科技部重点研发等共10余项科研基金，拥有3项国际专利。
教育背景：
2008 – 2013 博士，生物医学，新加坡国立大学, 新加坡
2002 – 2006 荣誉学士，生物学，新加坡国立大学，新加坡
工作经历：
08/2020 – 至今 助理教授，博士生导师，南方科技大学医学院，中国
07/2014 – 05/2020 HHMI 博士后，麻省总医院癌症中心／哈佛医学院，美国
04/2013 – 06/2014 过渡博士后, 新加坡科研局(A*STAR)／新加坡国立大学，新加坡
获奖情况及荣誉：
2020 美国癌症协会(AACR) Scholar-In-Training Award，美国
2013 新加坡科研局（A*STAR)青年基金（JCO Career Development Award), 新加坡
2007-2010 研究生奖学金（Junior Research Fellowship),淡马锡生命科学实验室(TLL),新加坡
2006 新加坡国立大学本科最佳毕业设计奖(LiJen Industrial Development Medal), 新加坡
2002-2006 教育部留学生奖学金（本科），新加坡教育部
研究领域：
癌症转移机制，液体活检术，循环肿瘤细胞 (CTC)：
建立基于CTC的癌转移动物模型（CDX)，研究CTC介导的癌远程转移分子生物学机制
结合新一代微流控CTC芯片技术和单细胞组学绘制CTC转移和增殖的癌细胞进化图谱
液体活检技术开发
开发和筛选抑制CTC远程转移的小分子药物
学术任职：
Theranostics (客座编辑，2021-2022)
BMC Cancer （副主编/编委，2022-至今）
Cancer Drug Resistance（青年编委，2022-至今）
Aging & Disease （青年编委，2023-至今）
发表论文：
* first/co-first authors; # corresponding/co-corresponding authors
1. Ye L*, Jiang Z*, Zheng M, Pan K, Lian J, Ju B, Liu X, Tang S, Guo G, Zhang S, Hong X#, Lu W#. Fatty acid metabolism-related lncRNA prognostic signature for serous ovarian carcinoma. Epigenomics. 2024 Feb 15. （#co-corresponding authors）
2. Jiang Z*, He J*, Zhang B*, Wang L, Long C, Zhao B, Yang Y, Du L, Luo W#, Hu J#, Hong X#. A Potential "Anti-Warburg Effect" in Circulating Tumor Cell-mediated Metastatic Progression? Aging Dis. 2024 Jan 11. （*Equal contributions;#co-corresponding authors）
3. Fox DB*, Ebright RY*, Hong X*, Russell HC, Guo H, LaSalle TJ, Wittner BS, Poux N, Vuille JA, Toner M, Hacohen N, Boland GM, Sen DR, Sullivan RJ, Maheswaran S#, Haber DA#. Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade. NPJ Precis Oncol. 2023 Mar 2;7(1):25.（*Equal contributions;#co-corresponding authors）
4. Hong X*, Roh W*, Sullivan R J, Wong K H K, Wittner B S, Guo H, Dubash T D, Sade-Feldman M, Wesley B, Horwitz E, Boland G M, Marvin D L, Bonesteel T, Lu C, Aguet F, Burr R, Freeman S S, Parida L, Calhoun K, Jewett M K, Nieman L T, Hacohen N, Naar A M, Ting D T, Toner M, Stott S L, Getz G, Maheswaran S, Haber D A. The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis. Cancer Discovery, 2021 Mar;11(3):678-695.（*Equal contributions）
5. Hong X*, Sullivan RJ*, Kalinich M, Kwan TT, Giobbie-Hurder A, Pan S, LiCausi JA, Milner JD, Nieman LT, Wittner BS, Ho U, Chen T, Kapur R, Lawrence DP, Flaherty KT, Sequist LV, Ramaswamy S, Miyamoto DT, Lawrence M, Toner M, Isselbacher KJ, Maheswaran S**, Haber DA**. Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2467-2472. (*Equal contributions; **co-corresponding authors)
6. Hong X*, Nguyen HT*, Chen Q, Zhang R, Hagman Z, Voorhoeve PM, Cohen SM. Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover. EMBO J. 2014 Nov 3;33(21):2447-57. (*Equal contributions)
7. Nguyen HT*, Hong X*, Tan S, Chen Q, Chan L, Fivaz M, Cohen SM, Voorhoeve PM. Viral small T oncoproteins transform cells by alleviating hippo-pathway-mediated inhibition of the YAP proto-oncogene. Cell Rep. 2014 Aug 7;8(3):707-13. (*Equal contributions)
8. Herranz H*, Hong X*, Hung NT, Voorhoeve PM, Cohen SM. Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev. 2012 Jul 15;26(14):1602-11. (* Equal contributions)
9. Hong X*, Hammell M*, Ambros V, Cohen SM. Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15085-90. (*Equal contributions)
10. Liu J, Lian J, Chen Y, Zhao X, Du C, Xu Y, Hu H, Rao H, Hong X#. Circulating Tumor Cells (CTCs): A Unique Model of Cancer Metastases and Non-invasive Biomarkers of Therapeutic Response. Frontiers in Genetics, 2021 Aug 25;12:734595.（#corresponding authors）
11. Hu J, He P, Zhao F, Lin W, Xue C, Chen J, Yu Z, Ran Y, Meng Y, Hong X, Shum PP, Shao L. Magnetic microspheres enhanced peanut structure cascaded lasso shaped fiber laser biosensor for cancer marker-CEACAM5 detection in serum. Talanta. 2024 Jan 5;271:125625.
12. Yuan S*, Xi S*, Weng H*, Guo MM, Zhang JH, Yu ZP, Zhang H, Yu Z, Xing Z, Liu MY, Ming DJ, Sah RK, Zhou Y, Li G, Zeng T, Hong X, Li Y, Zeng XT, Hu H. YTHDC1 as a tumor progression suppressor through modulating FSP1-dependent ferroptosis suppression in lung cancer. Cell Death Differ. 2023 Dec;30(12):2477-2490.（*Equal contributions）
13. Guo H S*, Golczer G*, Wittner B, Langenbucher A, Zachariah M, Dubash T D, Hong X, Comaills V, Burr R, Ebright R Y, Horwitz E, Vuille J A, Hajizadeh S, Wiley D F, Reeves B A, Zhang J M, Niederhoffer K L, Lu C Y, Wesley B, Ho U, Nieman L T, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S**, Lawrence M S**, Harber D A**. NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. Molecular Cell, 2021 Oct 7;81(19):4041-4058.e15.（*Equal contributions;**co-corresponding authors）
14. Xu H*, Li S*, Sun Y*, Xu L, Hong X, Wang Z, Hu H. ELOVL5-Mediated Long Chain Fatty Acid Elongation Contributes to Enzalutamide Resistance of Prostate Cancer. Cancers, 2021 Aug 5;13(16):3957. （*Equal contributions）
15. Che J, Hong X, Rao H. PCNA Ubiquitylation: Instructive or Permissive to DNA Damage Tolerance Pathways?. Biomolecules, 2021 Oct 19;11(10):1543.
16. Edd JF, Mishra A, Dubash TD, Herrera S, Mohammad R, Williams EK, Hong X, Mutlu BR, Walsh JR, Machado de Carvalho F, Aldikacti B, Nieman LT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M. Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes. Lab Chip. 2020 Feb 7;20(3):558-567.
17. Aya-Bonilla CA, Morici M, Hong X, McEvoy AC, Sullivan RJ, Freeman J, Calapre L, Khattak MA, Meniawy T, Millward M, Ziman M, Gray ES. Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells. Br J Cancer. 2020 Mar;122(7):1059-1067.
18. Yan C*, Brunson DC*, Tang Q*, Do D*, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM. Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Cell. 2019 Jun 13;177(7):1903-1914.e14. (*Equal contributions).
19. Miyamoto DT*, Lee RJ*, Kalinich M, LiCausi JA, Zheng Y, Chen T, Milner JD, Emmons E, Ho U, Broderick K, Silva E, Javaid S, Kwan TT, Hong X, Dahl DM, McGovern FJ, Efstathiou JA, Smith MR, Sequist LV, Kapur R, Wu CL, Stott SL, Ting DT, Giobbie-Hurder A, Toner M, Maheswaran S**, Haber DA**. An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer. Cancer Discov. 2018 Mar;8(3):288-303. (*Equal contributions; ** co-corresponding authors).
20. Kalinich M*, Bhan I*, Kwan TT, Miyamoto DT, Javaid S, LiCausi JA, Milner JD, Hong X, Goyal L, Sil S, Choz M, Ho U, Kapur R, Muzikansky A, Zhang H, Weitz DA, Sequist LV, Ryan DP, Chung RT, Zhu AX, Isselbacher KJ, Ting DT, Toner M, Maheswaran S**, Haber DA**. An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1123-1128. (*Equal contributions; ** co-corresponding authors).
21. Thanh Nguyen H, Andrejeva D, Gupta R, Choudhary C, Hong X, Eichhorn PJ, Loya AC, Cohen SM. Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover. Cell Discov. 2016 Mar 29;2:16001. doi: 10.1038/celldisc.2016.1.
22. Ge W, Deng Q, Guo T, Hong X, Kugler JM, Yang X, Cohen SM. Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA. Genetics. 2015 May;200(1):255-65.
23. Herranz H, Hong X, Cohen SM. Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr Biol. 2012 Apr 24;22(8):651-7.
24. Becam I*, Rafel N*, Hong X, Cohen SM, Milán M. Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. Development. 2011 Sep;138(17):3781-9. (*Equal contributions).
25. Herranz H, Hong X, Pérez L, Ferreira A, Olivieri D, Cohen SM, Milán M. The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J. 2010 May 19;29(10):1688-98.
26. Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, Soong TW. Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta. 2008 Jan;1783(1):118-30.
27. Tang ZZ, Hong X, Wang J, Soong TW. Signature combinatorial splicing profiles of rat cardiac- and smooth-muscle Cav1.2 channels with distinct biophysical properties. Cell Calcium. 2007 May;41(5):417-28.