师资

刘泉
副教授
医学院联合党委副书记、医学教职工联合党支部书记
0755-88018055
liuq3@sustech.edu.cn

个人简介

刘泉,医学院联合党委副书记、医学教职工联合党支部书记、中国生物医学工程学会免疫治疗工程分会移植免疫专业委员会副主任委员、副教授、博士生导师。1997年至2002年就读于哈尔滨医科大学,获医学学士学位。2002年至2005年就读于哈尔滨医科大学,获外科学(胸心外)硕士学位,并留校从医任教,奠定了心脏大血管外科的临床基础。2008年至2011年就读于哈尔滨医科大学,获外科学(胸心外)博士学位。2009年至2017年,在匹兹堡大学Thomas E. Starzl移植研究所先后以research fellow, postdoctoral associate 和research associate身份从事移植免疫学、炎症调控和Treg免疫生物学等方面的研究。

 

研究领域

1、肿瘤免疫及免疫治疗;

 2、神经-免疫-代谢的相互作用,特别是上皮细胞因子(如IL-33)、神经递质(如CGRP、NMU、NE等)等对ILC及Treg的免疫生物学作用;

 3、移植免疫。

 

教学

本科生:生物化学、生理学、病理生理学

研究生:免疫学

 

工作经历

2018.08-至今     副教授,南方科技大学医学院

2014.03-2017.04  Research Associate

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

2014.09-2018.08  副主任医师, 心血管外科,哈尔滨医科大学附属第二医院

2008.09-2014.08  主治医师, 心血管外科,哈尔滨医科大学附属第二医院

2005.07-2008.08  住院医师, 心血管外科,哈尔滨医科大学附属第二医院

 

教育背景

1997.09-2002.06    临床医学         本科    哈尔滨医科大学

2002.09-2005.06    外科学(胸心外) 硕士    哈尔滨医科大学

2008.09-2011.12    外科学(胸心外) 博士    哈尔滨医科大学

2009.02-2009.08    临床心/肺移植观摩

Presbyterian Hospital, University of Pittsburgh Medical Center, USA

2009.12-2012.03  Research fellow

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

2012.03-2014.02   博士后

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

 

已发表学术论文

  1.  Li T, Zhang Z, Bartolacci JG, Dwyer GK , Liu Q, Mathews L, Velayutham M, Roessing A, Lee YC, Dai H, Shiva S, Oberbarnscheidt MH, Dziki JL, Mullett SJ, Wendell SG, Wilkinson JD, Webber SA, Wood-Trageser MA, Watkins SC, Demetris AJ, Hussey GS, Badylak SF, Turnquist HR. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397-5412.Nature Index 期刊,影响因子14.808

  2. Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A Geller. iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice. Mol Med. 2020;26:56. 

  3. Xiao F, Lin L, Chao Z, Shao C, Chen Z, Wei Z, Lu J, Huang Y, Li L, Liu Q, Liang Y, Tian L. Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood–Brain Barrier. Angew Chem Int Ed Engl. 2020; 59:9702-9710. (Nature Index 期刊,影响因子15.336)

  4. Lin L, Li Y, Liu M, Li Q, Liu Q#, Li R#. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging. 2020;12:1685-1703. #共同通讯作者,影响因子5.682

  5. Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6). pii: 123919. 影响因子8.315

  6. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805-20. Nature Index 期刊,影响因子14.808,高被引

  7. Zhuang Q*, Liu Q*, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016;7:12623. *共同第一作者,Nature Index 期刊,影响因子14.919

  8. Liu Q, Wang Y, Nakao A, Zhang W, Gorantla V, Zheng XX. Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats. Clin Dev Immunol. 2013; 2013:483856.

  9. Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MJ, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39. (影响因子22.113)

  10. Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH1, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125:3183-92. (影响因子22.113)

  11. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39. (影响因子15.828)

  12. Rosborough BR, Raïch-Regué D, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014;14:2173-80. (影响因子8.086)

  13. Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, Turnquist HR. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol. 2014;193:4010-20.

  14. Rosborough BR, Mathews LR, Matta BM, Liu Q, Raïch-Regué D, Thomson AW, Turnquist HR.Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol. 2014;192:3470-3.

  15. Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller DA. Nitric Oxide Production Upregulates Wnt/β-catenin Signaling By Inhibiting Dickkopf-1. Cancer Res. 2013; 73: 6526-37. Nature Index 期刊, 影响因子12.701

  16. Cheng L, Guo H, Qiao X, Liu Q, Nie J, Li J, Wang J, Jiang K. T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading. Diagn Pathol. 2013;8:168.

  17. Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Stolz DB, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW. IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 2011; 187: 4598-610.

  18. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010; 116: 2694-705. (影响因子22.113)


    综述

  19. Liu Q, Turnquist HR. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant. 2016;21:45-52.

  20. Liu Q, Turnquist HR. Implications for Interleukin-33 in solid organ   transplantation. Cytokine. 2013;62:183-94.