个人简介

刘泉，医学博士，南方科技大学医学院联合党委副书记、医学院联合分工会主席、中国生物医学工程学会免疫治疗工程分会移植免疫专业委员会副主任委员、副教授、研究员、副主任医师，博士生导师。刘泉博士于哈尔滨医科大学获医学学士（2002）、硕士（2005）、博士（2011）学位。历任哈尔滨医科大学附属第二医院心脏大血管外科住院医师、主治医师、副主任医师。2009年至2017年，在匹兹堡大学Thomas E. Starzl移植研究所从事移植免疫学、炎症调控和IL-33免疫生物学等方面科学研究。2007和2008年两次获得黑龙江省科学技术二等奖，2013年获美国移植协会(AST)和美国移植外科医生协会(ASTS)联合颁发的青年科学家奖。移植免疫学研究成果被写入经典免疫学教材Janeway’s Immunobiology (10th Ed, 2022)。

研究领域

1、肿瘤免疫及免疫治疗。

2、神经-免疫-代谢的相互作用，特别是上皮细胞因子（如IL-33）、神经递质（如CGRP、NMU、NE等）等对ILC及Treg的免疫生物学作用；

 3、移植免疫。

主要科学发现

1、以移植物内供者树突状细胞为例，证明了供者细胞产生的外泌体是移植抗原提呈半直接途径的物质基础。

2、发现了移植物内受者来源的抗原提呈细胞维持移植排斥反应的作用。

3、发现了急性肺损伤过程中Treg和IL-33对组织修复的调节作用。

科研成果

1、关于移植抗原提呈机制的研究成果，被写入2022年7月出版的经典免疫学教材Janeway’s Immunobiology, 10th Ed (Chapter 15 Autoimmunity and Transplantation, Section 21 Alloreactive T cells reject transplanted organs by direct and indirect allorecognition)。

2、论文发表：发表SCI论文22篇，其中IF>20的期刊收录3篇，影响因子>10的期刊收录6篇，Nature Index期刊收录5篇。中文发表论文6篇。

3、基金项目：曾主持国家自然科学基金青年基金1项，已顺利结题；现主持国家自然科学基金面上项目1项。

工作经历

2018.08-至今     副教授，南方科技大学医学院

2014.03-2017.04  Research Associate

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

2014.09-2018.08  副主任医师, 心血管外科，哈尔滨医科大学附属第二医院

2008.09-2014.08  主治医师, 心血管外科，哈尔滨医科大学附属第二医院

2005.07-2008.08  住院医师, 心血管外科，哈尔滨医科大学附属第二医院

教育背景

1997.09-2002.06    临床医学         本科    哈尔滨医科大学

2002.09-2005.06    外科学（胸心外） 硕士    哈尔滨医科大学

2008.09-2011.12    外科学（胸心外） 博士    哈尔滨医科大学

2009.02-2009.08    临床心／肺移植观摩

Presbyterian Hospital, University of Pittsburgh Medical Center, USA

2009.12-2012.03  Research fellow

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

2012.03-2014.02   博士后

T.E. Starzl Transplantation Institute, University of Pittsburgh, USA

已发表学术论文

论著

1. Li T, Zhang Z, Bartolacci JG, Dwyer GK , Liu Q, Mathews L, Velayutham M, Roessing A, Lee YC, Dai H, Shiva S, Oberbarnscheidt MH, Dziki JL, Mullett SJ, Wendell SG, Wilkinson JD, Webber SA, Wood-Trageser MA, Watkins SC, Demetris AJ, Hussey GS, Badylak SF, Turnquist HR. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397-5412.（Nature Index期刊，影响因子19.456）

2. Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A Geller. iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice. Mol Med. 2020;26:56. 

3. Xiao F, Lin L, Chao Z, Shao C, Chen Z, Wei Z, Lu J, Huang Y, Li L, Liu Q, Liang Y, Tian L. Organic Spherical Nucleic Acids for the Transport of a NIR-II-Emitting Dye Across the Blood–Brain Barrier. Angew Chem Int Ed Engl. 2020; 59:9702-9710. (Nature Index期刊，影响因子16.823)

4. Lin L, Li Y, Liu M, Li Q, Liu Q#, Li R#. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging. 2020;12:1685-1703. （#共同通讯作者，影响因子5.955）

5. Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR. IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury. JCI Insight. 2019;4(6). pii: 123919. （影响因子9.484）

6. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016;126:2805-20. （Nature Index 期刊，影响因子19.456，高被引论文）

7. Zhuang Q*, Liu Q*, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016;7:12623. （*共同第一作者，Nature Index 期刊，影响因子17.694）

8. Liu Q, Wang Y, Nakao A, Zhang W, Gorantla V, Zheng XX. Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats. Clin Dev Immunol. 2013; 2013:483856.

9. Matta BM, Reichenbach DK, Zhang X, Mathews L, Koehn BH, Dwyer GK, Lott JM, Uhl FM, Pfeifer D, Feser CJ, Smith MJ, Liu Q, Zeiser R, Blazar BR, Turnquist HR. Peri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GVHD. Blood. 2016;128:427-39. (影响因子25.476)

10. Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH1, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood. 2015;125:3183-92. (影响因子25.476)

11. Xu J, Jiang Y, Wang J, Shi X, Liu Q, Liu Z, Li Y, Scott MJ, Xiao G, Li S, Fan L, Billiar TR, Wilson MA, Fan J. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ. 2014;21:1229-39. (影响因子12.067)

12. Rosborough BR, Raïch-Regué D, Liu Q, Venkataramanan R, Turnquist HR, Thomson AW. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014;14:2173-80. (影响因子9.369)

13. Matta BM, Lott JM, Mathews LR, Liu Q, Rosborough BR, Blazar BR, Turnquist HR. IL-33 is an unconventional alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells. J Immunol. 2014;193:4010-20. (影响因子5.426)

14. Rosborough BR, Mathews LR, Matta BM, Liu Q, Raïch-Regué D, Thomson AW, Turnquist HR.Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol. 2014;192:3470-3. (影响因子5.426)

15. Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller DA. Nitric Oxide Production Upregulates Wnt/β-catenin Signaling By Inhibiting Dickkopf-1. Cancer Res. 2013; 73: 6526-37. （Nature Index 期刊, 影响因子13.312）

16. Cheng L, Guo H, Qiao X, Liu Q, Nie J, Li J, Wang J, Jiang K. T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading. Diagn Pathol. 2013;8:168.

17. Zhang D, Shen M, Mikita A, Zhang W, Liu Y, Liu Q, Dai Y, Zhang C, Zheng S, Zheng XX. Targeting uncoupling protein-2 improves islet graft function. Cell Transplant. 2011;20:421-9.

18. Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Stolz DB, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW. IL-33 expands suppressive CD11b+ Gr-1int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol. 2011; 187: 4598-610. (影响因子5.426)

19. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010; 116: 2694-705. (影响因子25.476)

20. 刁力为,刘大勇,叶明,刘泉,亓峰,孙振东,陈子道,姚志发,吴乃石.热休克预适应对心脏移植供心保护作用的实验研究[J].哈尔滨医科大学学报,2010,44(05):443-446.

21. 吴乃石,刁力为,刘泉,赵林,亓锋,刘大勇.托拉塞米在重症心脏联合瓣膜置换病人围手术期中的应用[J].中国新药与临床杂志,2006(10):753-755.

22. 刘泉,吴乃石,孙露,赵林林,刁力为,陈子道,杜金荣.婴儿多发性心脏横纹肌瘤一例[J].中华外科杂志,2006(06):368.

23. 刘泉,臧旺福,田海.一种新的大鼠同种主动脉瓣异位移植模型[J].中华实验外科杂志,2005(10):114-115.

综述与述评

24. Liu Q, Turnquist HR. Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity. Curr Opin Organ Transplant. 2016;21:45-52.

25. Liu Q, Turnquist HR. Implications for Interleukin-33 in solid organ   transplantation. Cytokine. 2013;62:183-94.

26. 刘泉,杨木清,代贺龙.匹兹堡大学Starzl移植研究所学习期间的见闻与思考[J].实用器官移植电子杂志,2018,6(06):477-478.

27. 刘泉,齐忠权.移植免疫与器官再生的研究进展[J].实用器官移植电子杂志,2018,6(02):90-92.