师资
刘心元，南方科技大学讲席教授，化学系主任，国家自然科学杰出青年基金获得者，国自然优秀青年基金获得者，入选教育部特聘教授（青年）。1979年1月出生安徽安庆。2001年毕业于安徽师范大学化学系，获理学学士学位；2004年毕业于安徽师范大学化学系和上海有机所（联合培养），获理学硕士学位（导师：朱仕正研究员和王绍武教授）；2010年毕业于香港大学化学系，获哲学博士学位（导师：支志明院士）；2010-2012年香港大学和美国Scripps研究所博士后（导师：支志明院士和Carlos F. Barbas III教授）；2012年9月入职南方科技大学化学系，任副教授、课题组长； 2018年1月晋升为南方科技大学终身正教授；2022年11月晋升为讲席教授。刘心元团队自从南科大开展独立工作以来，围绕“不对称自由基催化化学”这一科学难题开展了深入系统的研究，提出了独具特色的“手性阴离子-金属单电子催化剂”新策略，开发了简单化工原料参与的不对称自由基催化反应，解决了高活性自由基手性控制难题，并拓展了其在资源分子高效利用和手性药物合成中的应用示范研究。以通讯作者身份在Nature （1）、Nat. Chem. (4)、Nat. Catal. (2)、Nat. Synth. (1)、Acc. Chem. Res. (1)、Chem (2)、J. Am. Chem. Soc. (13)、Angew. Chem. Int. Ed. (21)、Nat. Commun. (6)、Sci. Adv. (1)、CCS Chem (3)重要期刊发表多篇研究论文；申请专利15项。曾获新基石基金会科学探索奖、广东省自然科学一等奖、美国波士顿学院Boehringer-Ingelheim Lectureship、中国化学会-巴斯夫公司青年知识创新奖、中国化学会手性青年化学奖、基金委杰出青年基金、优秀青年基金、教育部青年长江学者、中美华人化学与化学生物学教授联合会杰出教授奖、日本化学会杰出讲席奖和亚洲核心计划讲座奖（三次）等奖项。
工作经历
2022年11月-至今 讲席教授，南方科技大学化学系
2018年1月-2022年11月 教授，南方科技大学化学系
2012年9月-2017年12月 副教授，南方科技大学化学系
2010年4月-2012年8月 博士后，美国斯克普斯研究所，香港大学。 导师： Carlos F. Barbas III，支志明
2004年7月-2005年8月 研究助理，中科院上海有机化学研究所。导师：赵刚
荣誉以及奖励
获奖及荣誉
2024，美国波士顿学院Boehringer-Ingelheim Lectureship
2024，中国化学会-巴斯夫公司青年知识创新奖
2023，新基石基金会“科学探索奖"
2023，广东省自然科学一等奖
2023，荣获新加坡颁发的亚洲尖端有机化学会讲席奖
2021，第五届中国化学会手性化学奖青年手性化学奖
2020，荣获国家自然科学基金杰出青年基金资助
2019，荣获日本和中国台湾分别颁发的亚洲尖端有机化学会讲席奖（ACP Lecture Award）
2019，荣获南方科技大学校长青年科研奖
2019，荣获中美华人教授会杰出教授奖（CAPA awards）
2018，教育部特聘教授（青年）
2017，国家自然科学基金优秀青年项目
2017，荣获日本化学会杰出教授奖
2016，荣获南方科技大学优秀科研奖
2013，入选深圳市海外高层次“孔雀计划”B类人才
2011，荣获香港大学2009-2010年杰出研究生奖
研究方向
自由基参与的不对称化学和有机氟化学
科研项目
国家杰出青年科学基金项目、400万、项目负责人; 2021.1-2025.12.
国家自然科学基金委优秀青年项目、130万、项目负责人; 2016.1-2019.12.
国家重点研发计划、460万、课题负责人; 2021.12-2025.11.
国家自然科学基金委重点项目、230万、项目负责人; 2024.1-2028.12.
国家自然科学基金重大研究计划项目、198.225万、课题负责人; 2023.1-2025.12.
广东省基础与应用基础重大项目、500万、项目负责人; 2023.12-2028.12.6.
代表性论文
112. Yu Tian+, Xi-Tao Li +, Ji-Ren Liu+, Jian Cheng+, Ang Gao+, Ning-Yuan Yang, Zhuang Li, Kai-Xin Guo, Wei Zhang, Han-Tao Wen, Zhong-Liang Li, Qiang-Shuai Gu, Xin Hong, Xin-Yuan Liu* "A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution" Nature Chemistry 2024, 16, 466.
111. Xuan-Yi Du+, Jia-Heng Fang+, Ji-Jun Chen+, Boming Shen+, Wei-Long Liu, Jia-Yong Zhang, Xue-Man Ye, Ning-Yuan Yang, Qiang-Shuai Gu, Zhong-Liang Li,* Peiyuan Yu,* Xin-Yuan Liu* "Copper-Catalyzed Enantioconvergent Radical N‑Alkylation of Diverse (Hetero)aromatic Amines" J. Am. Chem. Soc. 2024, 146, 9444.
110. Wei Zhang+, Yu Tian+, Xiao-Dong Liu, Cheng Luan, Ji-Ren Liu, Qiang-Shuai Gu, Zhong-Liang Li, Xin-Yuan Liu* "Copper-Catalyzed Enantioselective C(sp3)–SCF3 Coupling of Carbon-Centered Benzyl Radicals with (Me4N)SCF3" Angew. Chem. Int. Ed., 2024, 63, e202319850.
109. Jia-Heng Fang+, Ji-Jun Chen+, Xuan-Yi Du+, Zhe Dong+, Run-Yan Tian, Chang-Jiang Yang, Fu-Li Wang, Cheng Luan, Zhong-Liang Li, Xin-Yuan Liu* "Copper-Catalyzed Asymmetric Three-Component Radical 1,2-Carboamination of Acrylamideswith Arylamines: Access to Chiral α-Tertiary N-Arylamines" CCS Chem., 2024, DOI: 10.31635/ccschem.024.202404389.
108. Chang-Jiang Yang*, Lin Liu, Qiang-Shuai Gu* Xin-Yuan Liu* "Research Progress in Enantioselective Radical Desymmetrization Reactions" CCS Chem., 2024, DOI: 10.31635/ccschem.024.202403839.
107. Jia-Heng Fang, Run-YanTian, Ji-Jun Chen*, Xin-Yuan Liu* "Research Progress in the Synthesis of α-Tertiary Amines via Radical Strategies" Chinese Journal of Organic Chemistry, 2024, DOI: 10.6023/cjoc202406040.
106. Lin Liu,* Chang-Jiang Yang, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu* "The first-row transition metal-catalysed enantioconvergent radical Suzuki−Miyaura C(sp3)−C coupling of racemic alkyl halides" Green Chem., 2024, 26, 2525.
105. XU Dantong, LIANG Simou, YANG Changjiang, LI Zhongliang, GU Qiangshuai, LIU Lin*, LIU Xinyuan* "Copper-catalyzed asymmetric radical C(sp3)—C(sp2) bond formation with organoboron reagents" Journal of Molecular Science, 2024, 40, 1.
104. Ji-Jun Chen+, Jia-Heng Fang+, Xuan-Yi Du+, Jia-Yong Zhang, Jun-Qian Bian, Fu-Li Wang, Cheng Luan, Wei-Long Liu, Ji-Ren Liu, Xiao-Yang Dong, Zhong-Liang Li, Qiang-Shuai Gu, Zhe Dong, Xin-Yuan Liu* "Enantioconvergent Cu-catalyzed N-alkylation of aliphatic amines" Nature 2023, 618, 294.
103. Yong-Feng Cheng+, Zhang-Long Yu+, Yu Tian+, Ji-Ren Liu+, Han-Tao Wen, Na-Chuan Jiang, Jun-Qian Bian, Guo-Xiong Xu, Dan-Tong Xu, Zhong-Liang Li, Qiang-Shuai Gu ,* Xin Hong ,* Xin-Yuan Liu * "Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling" Nat. Chem. 2023, 15, 395.
102. Li-Lei Wang+, Huan Zhou+, Yu-Xi Cao+, Chi Zhang, Yang-Qing Ren, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu* "A general copper-catalysed enantioconvergent radical Michaelis–Becker-type C(sp3)–P cross-coupling" Nat. Synth. 2023, 2, 430.
101. Ji-Jun Chen+, Jia-Yong Zhang+, Jia-Heng Fang+, Xuan-Yi Du+, Hai-Dong Xia+, Bin Cheng+, Nan Li, Zhang-Long Yu, Jun-Qian Bian, Fu-Li Wang, Jing-Jing Zheng, Wei-Long Liu, Qiang-Shuai Gu, Zhong-Liang Li, Xin-Yuan Liu* "Copper-Catalyzed Enantioconvergent Radical C(sp3)−N Cross-Coupling of Activated Racemic Alkyl Halides with (Hetero)aromatic Amines under Ambient Conditions" J. Am. Chem. Soc. 2023, 145, 14686.
100. Zhang-Long Yu+, Yong-Feng Cheng+, Ji-Ren Liu, Wu Yang, Dan-Tong Xu, Yu Tian, Jun-Qian Bian, Zhong-Liang Li, Li-Wen Fan, Cheng Luan, Ang Gao, Qiang-Shuai Gu*, Xin-Yuan Liu* "Cu(I)-Catalyzed Chemo- and Enantioselective Desymmetrizing C−O Bond Coupling of Acyl Radicals" J. Am. Chem. Soc. 2023, 145, 6535.
99. Huan Zhou+, Li-Wen Fan+, Yang-Qing Ren, Li-Lei Wang, Chang-Jiang Yang, Qiang-Shuai Gu, Zhong-Liang Li*, Xin-Yuan Liu* "Copper-Catalyzed Chemo- and Enantioselective Radical 1,2-Carbophosphonylation of Styrenes" Angew. Chem. Int. Ed. 2023, 62, e20221852.
98. Fu-Li Wang+, Lin Liu+, Chang-Jiang Yang, Cheng Luan, Yang Jing, Ji-Jun Chen, Qiang-Shuai Gu, Zhong-Liang Li,* Xin-Yuan Liu* "Synthesis of α-Quaternary β-Lactams via Copper-Catalyzed Enantioconvergent Radical C(sp3)–C(sp2) Cross-Coupling with Organoboronate Esters" Angew. Chem. Int. Ed. 2023, 62, e202214709.
97. Ang Gao+, Yang-Qing Ren+, Cheng Luan, Yu Tian, Lin Liu, Qiang-Shuai Gu, Zhong-Liang Li, Chang-Jiang Yang*, Xin-Yuan Liu* "Copper-Catalyzed Intramolecular Radical Amination of Tertiary C(sp3)–H Bonds to Access α-Quaternary Pyrrolidines" Asian J. Org. Chem 2023, e202300220.
96. Yang-Qing Ren, Chang-Jiang Yang, Zhong-Liang Li, Qiang-Shuai Gu, Lin Liu,* Xin-Yuan Liu* "Copper-Catalyzed Radical Trifluoromethylalkynylation of Unactivated Alkenes with Terminal Alkynes" Journal of Fluorine Chemistry, 2023, 267, 110107.
95. Zhang-Long Yu, Zhong-Liang Li, Chang-Jiang Yang, Qiang-Shuai Gu*, Xin-Yuan Liu* "Research Progress on Copper-Catalyzed Enantioselective Desymmetrization of Diols" Acta Chim. Sinica 2023, 81, 955.
94. Jing-Jing Zheng+, Wei-Long Liu+, Qiang-Shuai Gu, Zhong-Liang Li, Ji-Jun Chen*, Xin-Yuan Liu* "Copper-Catalyzed Enantioconvergent Radical C(sp3)−N Cross-Coupling to Access Chiral α‑Amino-β-lactams" Precis. Chem. 2023, 1, 576.
93. Yu Tian, Xin-Yuan Liu* "Visible Light Induced Copper-Catalyzed Enantioselective Deaminative Arylation of Amino Acid Derivatives Assisted by Phenol" Chinese Journal of Organic Chemistry, 2023, 43, 4303.
92. Fu-Li Wang+, Chang-Jiang Yang+, Ji-Ren Liu+, Ning-Yuan Yang, Xiao-Yang Dong , Ruo-Qi Jiang, Xiao-Yong Chang , Zhong-Liang Li, Guo-Xiong Xu, Dai-Lei Yuan, Yu-Shuai Zhang, Qiang-Shuai Gu ,* Xin Hong * and Xin-Yuan Liu * "Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes" Nature Chemistry 2022, 14, 949.
91. Xian-Yan Cheng+, Yu-Feng Zhang+*, Jia-Huan Wang, Qiang-Shuai Gu, Zhong-Liang Li,* Xin-Yuan Liu* "A Counterion/Ligand-Tuned Chemo- and Enantioselective Copper-Catalyzed Intermolecular Radical 1,2-Carboamination of Alkenes" J. Am. Chem. Soc. 2022, 144, 18081.
90. Xiao-Yang Dong, Zhong-Liang Li, Qiang-Shuai Gu, Xin-Yuan Liu* "Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides" J. Am. Chem. Soc. 2022, 144, 17319.
89. Peng-Fei Wang+, Jiao Yu+, Kai-Xin Guo+, Sheng-Peng Jiang, Ji-Jun Chen, Qiang-Shuai Gu, Ji-Ren Liu, Xin Hong, Zhong-Liang Li,* Xin-Yuan Liu* "Design of Hemilabile N,N,N-Ligands in Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Benzyl/Propargyl Halides with Alkenylboronate Esters" J. Am. Chem. Soc. 2022, 144, 6442.
88. Wu Yang+, Lin Liu+, Jiandong Guo+, Shou-Guo Wang, Jia-Yong Zhang, Li-Wen Fan, Yu Tian, Li-Lei Wang, Cheng Luan, Zhong-Liang Li, Chuan He, Xiaotai Wang*, Qiang-Shuai Gu*, Xin-Yuan Liu* "Enantioselective Hydroxylation of Dihydrosilanes to Si-Chiral Silanols Catalyzed by In Situ Generated Copper(II) Species" Angew. Chem. Int. Ed. 2022, 61, e202205743.
87. Feng-Ling Qing,* Xin-Yuan Liu,* Jun-An Ma,* Qilong Shen,* Qiuling Song,* Pingping Tang* "A Fruitful Decadeof Organofluorine Chemistry: New Reagents and Reactions" CCS Chem. 2022, 4, 2518.
86. Jun-Bin Tang, Jun-Qian Bian, Yu-Shuai Zhang, Yong-Feng Cheng, Han-Tao Wen, Zhang-Long Yu, Zhong-Liang Li, Qiang-Shuai Gu,* Guo-Qiang Chen,* and Xin-Yuan Liu* "Copper-Catalyzed anti-Selective Radical 1,2-Alkylarylation of Terminal Alkynes" Org. Lett. 2022, 24, 2536.
85. Cheng Luan+, Chang-Jiang Yang+, Lin Liu, Qiang-Shuai Gu,* Xin-Yuan Liu* "Transition metal-catalyzed enantioselective C–P coupling reactions for the construction of P-stereogenic centers" Chem Catalysis 2022, 2, 2876.
84. Na Wang, Li-Wen Fan, Jin Zhang, Qiang-Shuai Gu, Jin-Shun Lin, Guo-Qiang Chen,* Xin-Yuan Liu* and Peiyuan Yu* "Chiral N-triflylphosphoramide-catalyzed asymmetric hydroamination of unactivated alkenes: a hetero-ene reaction mechanism" Org. Chem. Front. 2022, 9, 1649
83. Lin Liu, Kai-Xin Guo, Yu Tian, Chang-Jiang Yang, Qiang-Shuai Gu, Zhong-Liang Li, Liu Ye*, and Xin–Yuan Liu* "Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)−H/C(sp)−H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligand" Angew. Chem. Int. Ed. 2021, 60, 26710
82. Yu-Feng Zhang+, Xiao-Yang Dong+, Jiang-Tao Cheng+, Ning-Yuan Yang, Li-Lei Wang, Fu-Li Wang, Cheng Luan, Juan Liu, Zhong-Liang Li, Qiang-Shuai Gu, and Xin-Yuan Liu* "Enantioconvergent Cu-Catalyzed Radical C−N Coupling of Racemic Secondary Alkyl Halides to Access α‑Chiral Primary Amines" J. Am. Chem. Soc. 2021, 143, 15413
81. Chi Zhang, Zhong-Liang Li, Qiang-Shuai Gu* & Xin-Yuan Liu* "Catalytic enantioselective C(sp3)–Hfunctionalization involving radical intermediates" Nat. Commun. 2021, 12, 475
80. Huan Zhou+, Zhong-Liang Li+, Qiang-Shuai Gu, and Xin-Yuan Liu* "Ligand-Enabled Copper(I)-Catalyzed Asymmetric Radical C(sp3)−C Cross-Coupling Reactions" ACS Catal. 2021, 11, 7978
79. Jiao Yu, Ning-Yuan Yang, Jiang-Tao Cheng, Tian-Ya Zhan, Cheng Luan, Liu Ye, Qiang-Shuai Gu, Zhong-Liang Li,* Guo-Qiang Chen,* and Xin-Yuan Liu* "Copper-Catalyzed Radical 1,2-Carbotrifluoromethylselenolation of Alkenes under Ambient Conditions" Org. Lett. 2021, 23, 1945
78. Zheng-Hua Zhang, He Wei, Zhong-Liang Li*, Xin-Yuan Liu* "Recent Advances in Radical-Involved Alkynylation of Unactivated C(sp3)–H Bonds by Hydrogen Atom Abstraction" Synlett, 2021, 32, 362
77. Xiao-Long Su+, Sheng-Peng Jiang+, Liu Ye , Guo-Xing Xu, Ji-Jun Chen, Qiang-Shuai Gu, Zhong-Liang Li* , Xin-Yuan Liu* "A general copper-catalyzed radical C(sp3)-C(sp2) cross-coupling to access 1,1-diarylalkanes under ambient conditions" Tetrahedron, 2021, 89, 132152
76. Zhuang Li+, Xian-Yan Cheng+, Ning-Yuan Yang, Ji-Jun Chen, Wen-Yue Tang, Jun-Qian Bian, Yong-Feng Cheng, Zhong-Liang Li, Qiang-Shuai Gu,* and Xin-Yuan Liu* "A Cobalt-Catalyzed Enantioconvergent Radical Negishi C(sp3)−C(sp2) Cross-Coupling with Chiral Multidentate N,N,P‑Ligand" Organometallics, 2021, 40, 2215
75. Ning-Yuan Yang, Zhong-Liang Li,* Xin-Yuan Liu* "Recent progress in 1,1-diborylalkanes-involved asymmetric synthesis" Journal of Molecular Science, 2021, 37, 1-8
74. Huan Zhou, Xin-Yuan Liu* "Photoinduced Copper-Catalyzed Asymmetric C—O Cross-Coupling" Chinese Journal of Organic Chemistry, 2021, 41, 4510
73. Xiao-Yang Dong+, Tian-Ya Zhan+, Sheng-Peng Jiang, Xiao-Dong Liu, Liu Ye, Zhong-Liang Li, Qiang- Shuai Gu, and Xin-Yuan Liu* "Copper-Catalyzed Asymmetric Coupling of Allenyl Radicals with Terminal Alkynes to Access Tetrasubstituted Allenes" Angew. Chem. Int. Ed. 2021, 60, 2160.
72. Xiao-Long Su+, Liu Ye+, Ji-Jun Chen+, Xiao-Dong Liu+, Sheng-Peng Jiang, Fu-Li Wang, Lin Liu, Chang-Jiang Yang, Xiao-Yong Chang, Zhong-Liang Li, Qiang-Shuai Gu, and Xin-Yuan Liu* "Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp3)–H Bonds" Angew. Chem. Int. Ed. 2021, 60, 380
71. Sheng-Peng Jiang, Xiao-Yang Dong, Qiang-Shuai Gu, Liu Ye, Zhong-Liang Li,* and Xin-Yuan Liu* "Copper-Catalyzed Enantioconvergent Radical Suzuki–Miyaura C(sp3)–C(sp2) Cross-Coupling" J. Am. Chem. Soc. 2020, 142, 19652
70. Zhe Wang,+ Jiang-Tao Cheng,+ Zhichao Shi, Na Wang, Feng Zhan, Sheng-Peng Jiang, Jin-Shun Lin,* Yuyang Jiang,* Xin-Yuan Liu* "Catalytic Asymmetric Intermolecular Radical Aminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis" ChemCatChem, 2020, 13, 185
69. Hai-Dong Xia,+ Zhong-Liang Li,+ Qiang-Shuai Gu,+ Xiao-Yang Dong,+ Jia-Heng Fang, Xuan-Yi Du, Li-Lei Wang, and Xin-Yuan Liu* "Photoinduced Copper-Catalyzed Asymmetric Decarboxylative Alkynylation with Terminal Alkynes" Angew. Chem. Int. Ed. 2020, 59, 16926
68. Chang-Jiang Yang+, Chi Zhang+, Qiang-Shuai Gu+ , Jia-Heng Fang, Xiao-Long Su, Liu Ye, Yan Sun, Yu Tian, Zhong-Liang Li and Xin-Yuan Liu* "Cu-catalysed intramolecular radical enantioconvergent tertiary β-C(sp3)–H amination of racemic ketones" Nature Catalysis 2020, 3, 539
67. Yong-Feng Cheng+, Ji-Ren Liu+, Qiang-Shuai Gu+, Zhang-Long Yu+, Jian Wang, Zhong-Liang Li, Jun-Qian Bian, Han-Tao Wen, Xiao-Jing Wang, Xin Hong* & Xin-Yuan Liu* ”Catalytic enantioselective desymmetrizing functionalization of alkyl radicals via Cu(I)/CPA cooperative catalysis” Nature Catalysis 2020, 3, 401
66. Xiao-Yang Dong+, Jiang-Tao Cheng+, Yu-Feng Zhang+, Zhong-Liang Li+, Tian-Ya Zhan, Ji-Jun Chen, FuLi Wang, Ning-Yuan Yang, Liu Ye, Qiang-Shuai Gu, and Xin-Yuan Liu* ''Copper-Catalyzed Asymmetric Radical 1,2-Carboalkynylation of Alkenes with Alkyl Halides and Terminal Alkynes'' J. Am. Chem. Soc. 2020, 142, 9501
65. Xi-Tao Li+, Ling Lv+, Ting Wang+, Qiang-Shuai Gu, Guo-Xing Xu, Zhong-Liang Li, Liu Ye, Xinhao Zhang, Gui-Juan Cheng,* and Xin-Yuan Liu* ”Diastereo- and Enantioselective Catalytic Radical Oxysulfonylation of Alkenes in β,γ-Unsaturated Ketoximes” Chem 2020, 6, 1692
64. Zhong-Liang Li,† Gui-Chun Fang,† Qiang-Shuai Gu † and Xin-Yuan Liu * ''Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes'' Chem. Soc. Rev. 2020, 49, 32
63. Zhang-Long Yu+, Yong-Feng Cheng+, Na-Chuan Jiang, Jian Wang, Li-Wen Fan, Yue Yuan, Zhong-Liang Li, Qiang-Shuai Gu* and Xin-Yuan Liu* ''Desymmetrization of unactivated bis-alkenes via chiral Brønsted acid-catalysed hydroamination'' Chem. Sci. 2020, 11, 5987
62. Yu-Xi Cao, Xiao-Yang Dong, Jun Yang, Sheng-Peng Jiang, Shuangliu Zhou, Zhong-Liang Li,* Guo-Qiang Chen,* and Xin-Yuan Liu* ”A Copper‐Catalyzed Sonogashira Coupling Reaction of Diverse Activated Alkyl Halides with Terminal Alkynes Under Ambient Conditions” Adv. Synth. Catal. 2020, 362, 2280
61. Zhen-Hua Zhang+, Xiao-Yang Dong+, Xuan-Yi Du+, Qiang-Shuai Gu , Zhong-Liang Li & Xin-Yuan Liu*''Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkyne'' Nature Communications 2019, 10, 5689
60. Liu Ye+, Yu Tian+, Xiang Meng, Qiang-Shuai Gu and Xin-Yuan Liu* ''Cu(I)/Chiral Phosphoric Acid-Catalyzed Radical-Involved Enantioselective Intramolecular Amination of Allylic and Benzylic C–H Bonds'' Angew. Chem. Int. Ed. 2020, 59, 1129
59. Xiao-Yang Dong+, Yu-Feng Zhang+, Can-Liang Ma+, Qiang-Shuai Gu+, Fu-Li Wang+, Zhong-Liang Li, Sheng-Peng Jiang and Xin-Yuan Liu * "A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling" Nature Chemistry 2019, 11, 1158
58. Qiang-Shuai Gu, Zhong-Liang Li, and Xin-Yuan Liu* "Copper(I)-Catalyzed Asymmetric Reactions Involving Radicals" Acc. Chem. Res. 2020, 53, 170.
57. Jin-Shun Lin, Tao-Tao Li, Ji-Ren Liu, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong*, and Xin-Yuan Liu*, "Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes." J. Am. Chem. Soc. 2019, 141, 1074.
56. Jin-Shun Lin, Tao-Tao Li, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and Xin-Yuan Liu*, "Chiral Brønsted Acid‐Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes." Angew. Chem. Int. Ed. 2019, 58, 7092.
55. Yang Zeng, Xiao-Dong Liu, Xian-Qi Guo, Qiang-Shuai Gu*, Zhong-Liang Li*, Xiao-Yong Chang & Xin-Yuan Liu* "Cu/Chiral Phosphoric Acid-Catalyzed Radical-Initiated Asymmetric Aminosilylation of Alkene with Hydrosilane" SCIENCE CHINA Chemistry 2019, 62, doi: 10.1007/s11426-019-9528-2.
54. Gui‑Chun Fang, Yong‑Feng Cheng, Zhang‑Long Yu, Zhong‑Liang Li, Xin‑Yuan Liu，"Recent Advances in First‑Row Transition Metal/Chiral Phosphoric Acid Combined Catalysis." Top. Curr. Chem. 2019, 377, 23.
53. Na Wang, Qiang-Shuai Gu, Zhong-Liang Li, Zhuang Li, Yu-Long Guo, Zhen Guo, and Xin-Yuan Liu*, "Direct Photocatalytic Synthesis of Medium-Sized Lactams through C–C Bond Cleavage." Angew. Chem. Int. Ed. 2018, 57, 14225.
52. Xi-Tao Li, Qiang-Shuai Gu, Xiao-Yang Dong, Xiang Meng, and Xin-Yuan Liu*, "Cinchona Alkaloid‐Based Sulfonamide/Copper Catalyst for Asymmetric Radical Oxytrifluoromethylation of Alkenyl Oximes." Angew. Chem. Int. Ed. 2018, 57, 7668.
51. Liu Ye, Qiang-Shuai Gu, Guo-Cong Chen, and Xin-Yuan Liu,* "Construction of Bicyclo[3.1.0]hexanes Containing Vicinal All-Carbon Quaternary Stereocenters via Radical Asymmetric Intramolecular α-Cyclopropanation of Aldehydes." Nat. Commun. 2018, 9, 227.
50. Jin-Hao Zhao, Yong Yang, Jin-Xin Che, Jun Zuo, Xiao-Hua Li, Yong-Zhou Hu, Xiao-Wu Dong,* Liang Gao,* and Xin-Yuan Liu*, “Compartmentalization of Incompatible Polymers within Metal–Organic Frameworks towards Homogenization of Heterogeneous Hybrid Catalysts for Tandem Reactions.” Chem. Eur. J. 2018, 24, 9903.
49. Na Wang, Jian Wang, Yu-Long Guo, Lei Li, Yan Sun, Zhuang Li, Hong-Xia Zhang, Zhen Guo, Zhong-Liang Li* and Xin-Yuan Liu *, “Oximinotrifluoromethylation of unactivated alkenes under ambient conditions.” Chem. Commun. 2018, 54, 8885.
48. Na Wang, Liu Ye, Zhong-Liang Li, Lei Li, Zhuang Li, Hong-Xia Zhang, Zhen Guo, QiangShuai Gu* and Xin-Yuan Liu*, “Hydrofunctionalization of Alkenols Triggered by Addition of Diverse Radicals to Unactivated Alkenes and Subsequent Remote Hydrogen Atom Translocation.” Org. Chem. Front. 2018, 5, 2810.
47. Xiao-Wu Dong*, Yong Yang, Jin-Xin Che, Jun Zuo, Xiao-Hua Li, Liang Gao, Yong-Zhou Hu and Xin-Yuan Liu*, “Heterogenization of homogeneous chiral polymers in metal–organic frameworks with enhanced catalytic performance for asymmetric catalysis.” Green Chem. 2018, 20, 4085.
46. Xi-Tao Li, Ling Lv, Qiang-Shuai Gu,*, and Xin-Yuan Liu*, “Copper-catalyzed radical oxytrifluoromethylation of alkenyl oximes at ambient temperature.” Tetrahedron, 2018, 74, 6041.
45. Yu Tian, Su Chen, Qiang-Shuai Gu, Jin-Shun Lin, Xin-Yuan Liu*, “Amino- and azidotrifluoromehtylation of alkenes.” Tetrahedron Lett. 2018, 59, 203. (Invited Digest)
44. Na Wang, Qiang-Shuai Gu*, Yong-Feng Cheng, Lei Li, Zhong-Liang Li, Zhen Guo*, and Xin-Yuan Liu*, “Visible-Light Promoted Preparation of Trifluoromethylated Tetrahydrofuran and Tetrahydropyran.” Chin. J. Org. Chem. 2019, 39, 200.
43. Xue-Fei Li, Jin-Shun Lin, Jian Wang, Zhong-Liang Li, Qiang-Shuai Gu, and Xin-Yuan Liu*, “Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Radical- Initiated Aminoarylation of Alkenes.” Acta Chim. Sinica 2018, 76, 878.
42. Fu-Li Wang, Xiao-Yang Dong, Jin-Shun Lin, Yang Zeng, Guan-Yuan Jiao, Qiang-Shuai Gu, Xian-Qi Guo, and Xin-Yuan Liu*, “Catalytic Asymmetric Diamination of Unactivated Alkene with Dialkylaminyl Radical” Chem 2017, 3, 979.
41. Lei Li, Zhong-Liang Li, Qiang-Shuai Gu, Na Wang, Xin-Yuan Liu,* "A Remote Radical Vinyl Migration Strategy to Access Medium- and Large-sized Cyclic Alkenes" Sci. Adv. 2017, 3, e1701487.
40. Lei Li, Liu Ye, Shao-Fei Ni, Zhong-Liang Li, Su Chen, Yi-Meng Du, Xiao-Hua Li, Li Dang* and Xin-Yuan Liu,* "Phosphine-catalyzed remote α-C–H bond activation of alcohols or amines triggered by the radical trifluoromethylation of alkenes: reaction development and mechanistic insights" Org. Chem. Front. 2017, 4, 2139.
39. Xue-Fei Li, Jin-Shun Lin and Xin-Yuan Liu,* “Catalytic Radical Intramolecular Aminoperfluoroalkylation and Aminodifluoromethylation of Unactivated Alkenes with Fluoroalkylsulfonyl Chlorides” Synthesis 2017, 49, 4213.
Published as part of the Special Topic Modern Cyclization Strategies in Synthesis
38. Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong, Wei-Wei He, Yue Yuan, Su Chen, and Xin-Yuan Liu,* "Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines" Nat. Commun. 2017, 8, 14841.
37. Yong-Feng Cheng, Xiao-Yang Dong, Qiang-Shuai Gu, Zhang-Long Yu, and Xin-Yuan Liu* “Achiral Pyridine Ligand-Enabled Enantioselective Radical Oxytrifluoromethylation of Alkenes with Alcohols” Angew. Chem., Int. Ed. 2017, 56, 8883.
Selected as Cover pictures.
Highlighted by Synfacts 2017, 13(10), 1042.
36 Taotao Li, Peng Yu, Yi-Meng Du, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,* "Dual-Catalyzed Enantioselective Remote C−H Functionalization Triggered by Radical Trifluoromethylation of Alkenes: Highly Selective Formation of C−CF3 and C−C Bonds" J. Fluorine Chem. 2017, 203, 210. (invited paper for a special issue).
35 Lei Li, Qiang-Shuai Gu, Na Wang, Ping Song, Zhong-Liang Li, Xiao-Hua Li, Fu-Li Wang, and Xin-Yuan Liu,* "1,2-Difunctionalization-Type (Hetero)arylation of Unactivated Alkenes Triggered by Radical Addition/Remote (Hetero)aryl Migration" Chem. Commun. 2017, 53, 4038.
34. Ping Song, Peng Yu, Jin-Shun Lin, Yiqun Li,* Ning-Yuan Yang, and Xin-Yuan Liu,* "Transition-Metal-Free β C−H Bond Carbonylation of Enamides or Amides with a Trifluoromethyl Group as CO Surrogate for the Synthesis of 1,3-Oxazin-6-ones" Org. Lett. 2017, 19, 1330.
33. Lei Li, Zhong-Liang Li, Fu-Li Wang, Zhen Guo, Yong-Feng Cheng, Na Wang, Chao Fang, Jingjiang Liu, Chunhui Hou, Bin Tan, and Xin-Yuan Liu,* "Radical Aryl Migration Enables Diversity-Oriented Synthesis of Structurally Diverse Medium/Macro- or Bridged-Rings" Nat. Commun. 2016, 7, 13852.
32. Zhong-Liang Li, Xiao-Hua Li, Na Wang, Ning-Yuan Yang, and Xin-Yuan Liu,* "Radical-Mediated 1,2-Formyl/carbonyl-Functionalization of Alkenes and Application to Construction of Medium-Sized-, Fused-, and Bridged-Ring Systems" Angew. Chem., Int. Ed. 2016, 55, 15100.
31. Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu,* "A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes" J. Am. Chem. Soc. 2016, 138, 9357.
Highlighted by “Synfacts 2016, 1020”. Highlighted by “Chin. J. Org. Chem. 2016, 36, 2247”.
30. Lin Huang, Liu Ye, Xiao-Hua Li, Zhong-Liang Li, Jin-Shun Lin, and Xin-Yuan Liu,* "Stereoselective Radical Cyclization Cascades Triggered by Addition of Diverse Radicals to Alkynes to Construct 6(5)‐6‐5 Fused Rings" Org. Lett., 2016, 18, 5284.
29. Na Wang, Lei Li, Zhong-Liang Li, Ning-Yuan Yang, Zhen Guo,* Hong-Xia Zhang, and Xin-Yuan Liu,* "Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies" Org. Lett., 2016, 18, 6026.
28. Ning-Yuan Yang, Zhong-Liang Li, Liu Ye, Bin Tan, and Xin-Yuan Liu,* "Organic base-catalysed solvent-tuned chemoselective carbotrifluoromethylation and oxytrifluoromethylation of unactivated alkenes" Chem. Commun., 2016, 52, 9052.
From themed collection 2016 Emerging Investigators by Chem. Commun.
27. Xiao-Long Yu, Liping Kuang, Su Chen, Xiao-Long Zhu, Zhong-Liang Li, Bin Tan, and Xin-Yuan Liu,* "Counteranion-Controlled Unprecedented Diastereo- and Enantioselective Tandem Povarov Reaction for Construction of Bioactive Octahydro-dipyrroloquinolines" ACS Catal. 2016, 6, 6182.
26. Na Wang, Sheng-Cai Zheng, Lin-Lin Zhang, Zhen Guo,* and Xin-Yuan Liu* "Nickel(0)-Catalyzed Denitrogenative Transannulation of Triazoles with Alkynes: Mechanistic Insights of Chemical Reactivity, Regio- and Enantioselectivity from Density Functional Theory and Experiment" ACS Catal. 2016, 6, 3496.
25. Taotao Li, Peng Yu, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,* "Copper-Catalyzed Redox-Triggered Remote C–H Functionalization: Highly Selective Formation of C–CF3 and C–O Bonds" Chin. J. Chem. 2016, 34, 490.
Invited paper for the Special Issue of “Trifluoromethylation and Trifluoromethythiolation Reactions”
24. Can-Liang Ma, Xiao-Hua Li, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong,* Bin Tan,* and Xin-Yuan Liu,* "Gold-catalyzed tandem synthesis of bioactive spiro-dipyrroloquinolines and its application in the one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I)" Org. Chem. Front. 2016, 3, 324.
From themed collection 2015 Emerging Investigators by OCF.
23. Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* and Xin-Yuan Liu,* "Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation" Angew. Chem., Int. Ed. 2015, 54, 9528.
Highlighted by “Synfacts 2015, 11, 1029”.
22. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu,* "Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter" Angew. Chem., Int. Ed. 2015, 54, 7847.
Highlighted by “Chin. J. Org. Chem. 2015, 35, 1802”.
21. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* and Xin-Yuan Liu,* "Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles" Angew. Chem., Int. Ed. 2015, 54, 4041.
Selected for a Cover Picture.
20. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu,* "Enantioselective C–H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene" Angew. Chem., Int. Ed. 2014, 53, 11890.
Highlighted by “Synfacts 2014, 10, 1281”. Highlighted by “Angew. Chem., Int. Ed. 2017, 56, 49”.
19. Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu,* and Bin Tan,* "Discovery and Enantiocontrol of Axially Chiral Urazoles via Organocatalytic Tyrosine Click Reaction" Nat. Commun. 2016, 7, 10677.
18. Jian Zhang, Shao-Xia Lin, Dao-Juan Cheng, Xin-Yuan Liu,* and Bin Tan,* "Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction" J. Am. Chem. Soc. 2015, 137, 14039.
Highlighted by “Synfacts 2016, 12, 86”.
17. Ye-Hui Chen, Dao-Juan Cheng, Jian Zhang, Yong Wang, Xin-Yuan Liu,* Bin Tan,* "Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2 Naphthols" J. Am. Chem. Soc. 2015, 137, 15062.
16. Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu,* and Bin Tan,* "Asymmetric Construction of Spirooxindoles via Organocatalytic Multicomponent Reactions of Diazooxindoles" Angew. Chem., Int. Ed. 2015, 54, 9409.
15. Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan,* "Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid" Angew. Chem., Int. Ed. 2014, 53, 3684.
Highlighted by “Synfacts 2014, 10, 530”.
14. Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu,* "Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam" ACS Catal. 2015, 5, 2826.
13. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu,* "Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes" Org. Lett. 2015, 17, 1589.
12. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu,* "Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds" Chem. Eur. J. 2015, 21, 6718.
11. Can-Liang Ma, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong, Bin Tan,* and Xin-Yuan Liu,* "Platinum-Catalyzed Tandem Cyclization Reaction to Multiply Substituted Indolines under Microwave-Assisted Conditions" Adv. Synth. Catal. 2015, 357, 569.
10. Lei Li, Jing-Yao Guo, Xing-Guo Liu, Su Chen, Yong Wang, Bin Tan,* and Xin-Yuan Liu,* "Amide Groups Switch Selectivity: C–H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation" Org. Lett., 2014, 16, 6032.
9. Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu,* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles" J. Org. Chem. 2014, 79, 7084.
8. Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu,* and Bin Tan,* "In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles" Org. Lett. 2014, 16, 2192.
Highlighted by “Synfacts 2014, 10, 754”.
7. Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu,* "Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement" Org. Lett. 2014, 16, 1000.
This work is highlighted on the website http://www.organic-chemistry.org/abstracts/lit4/389.shtm
6. Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan,* and Xin-Yuan Liu,* "Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles" Org. Lett. 2014, 16, 504.
5. Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu,* "Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles" Chem. Eur. J. 2014, 20, 1332.
4. Tao Liu, Da-Qiang Li, Si-Yu Wang Yong-Zhou Hu, Xiao-Wu Dong,* Xin-Yuan Liu,* and Chi-Ming Che, "Straightforward Installation of Carbon-Halogen, Carbon-Oxygen and Carbon-Carbon Bonds within Metal–Organic Frameworks via Direct C–H Functionalization" Chem. Commun., 2014, 50, 13261.
Highlighted by “Synfacts 2014, 10, 1272”.
3. Tao Liu, Jin-Xin Che, Yong-Zhou Hu, Xiao-Wu Dong,* Xin-Yuan Liu,* and Chi-Ming Che "Alkenyl/thiol-derived Metal–Organic Frameworks via Post-Synthetic Modification for Effective Mercury Adsorption" Chem. Eur. J. 2014, 20,14090.
2. Xiao-Wu Dong, Tao Liu, Yong-Zhou Hu,* Xin-Yuan Liu,* and Chi-Ming Che "Urea Postmodified in Metal-Organic Framework as Catalytically Active Hydrogen-Bond-Donating Heterogeneous Catalyst" Chem. Commun., 2013, 49, 7681.
Highlighted with a front cover in Chem. Commun.;
Selected as one of HOT Chem. Comm. articles for May;
Highlighted by “Synfacts 2013, 9, 1251”.
1. Gaosheng Yang,* Chongrong Luo, Xiaolong Mu, Tingting Wang, and Xin-Yuan Liu,* "Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas" Chem. Commun. 2012, 48, 5880.