师资

罗智
副教授
luoz@sustech.edu.cn

罗智副教授,南方科技大学生物医学工程系副教授、博士生导师。先后取得清华大学学士,瑞士洛桑联邦理工(EPFL)优等博士学位(导师为Francesco Stellacci 教授,欧洲科学院院士),并在瑞士苏黎世联邦理工(ETH)药学系完成博士后研究(合作导师为Jean-Christophe Leroux 教授,欧洲科学院院士)。2021年全职加入南方科技大学生物医学工程系,入选国家级“海外高层次人才引进计划”,建立仿生医药与材料实验室(Laboratory of bioinspired medicine and materials)。近五年发表学术论文近20篇,包括PNAS, Nat. Commun., Sci. Adv., Angew. Chem. Int. Ed., Acc. Chem. Res.,Adv. Drug Deliv. Rev.等国际知名期刊;在口服药物递送领域科研成果已进入人体实验阶段,与多个跨国药企保持长期合作。


教育背景  

2013 – 2018     洛桑联邦理工 (EPFL) ,材料系           博士   

2009 – 2013     清华大学,化学工程系                      本科


工作经历  

2021–至今       南方科技大学,生物医学工程系           副教授

2018 – 2021     苏黎世联邦理工 (ETHZ),药学系         博士后


荣誉奖励

2020年    苏黎世联邦理工-药学青年科学家奖

2019年    苏黎世联邦理工学者人才计划 (ETH Fellow) 

2018年    EPFL Distinction 荣誉博士学位

2018年    国家优秀自费留学奖学金

2016年    德国海因茨-迈尔-莱布尼茨研究所年度最佳论文

2012年    清华大学于曹简禹奖学金


研究兴趣

实验室拥有多学科高度交叉的研究背景,包括材料物理化学,药学,同步辐射及中子散射大型仪器表征等。研究思路为从复杂的医学、生命现象出发,提炼出普遍的基础科学问题;将先进的仪器表征、分析方法引入到新型医药材料的探索之中;最终利用这些理论技术开发创新药物及其递送方式。特别关注口服药物递送领域,将材料表界面,超分子化学,3D打印等概念和工具用于设计新的药物分子及递送体系,解决临床上未被满足的需求。


代表论文

[1] "Physical methods for enhancing drug absorption from the gastrointestinal tract."  Z. Luo, N. Paunović, J-C Leroux. Adv. Drug Deliv. Rev., 175 (2021): 113914

[2] "Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces."  Z. Luo, A. Murello, D. M. Wilkins, F. Kovacik, J. Kohlbrecher, A. Radulescu, H. I. Okur, Q. K. Ong, S. Roke, M. Ceriotti, F. Stellacci. PNAS, 116, no. 51 (2019): 25516-25523

[3] "Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology." Z. Luo, Y. Zhao, T. Darwish, Y. Wang, J. Hou, F. Stellacci. Nat. Comm., 9, no. 1 (2018): 4478.

[4] "Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering." Z. Luo, D. Marson, Q. K. Ong, A. Loiudice, J. Kohlbrecher, A. Radulescu, A. Krause-Heuer, T. Darwish, S. Balog, R. Buonsanti, D. I. Svergun, P. Posocco, F. Stellacci. Nat. Comm., 9, no. 1 (2018): 1343.

[5] "Evolution of the Ligand Shell Morphology during Ligand Exchange Reactions on Gold Nanoparticles." Z. Luo‡, J. Hou‡, L. Menin, Q. K. Ong, F. Stellacci.  Angew. Chem., Int. Ed. 129, no. 43 (2017): 13706-13710.

[6] "Characterization of Ligand Shell for Mixed-Ligand Coated Gold Nanoparticles." Q. K. Ong‡, Z. Luo‡, F. Stellacci. Acc. Chem. Res., 50, no. 8 (2017): 1911-1919.

[7] "Multi-dimensional characterization of mixed ligand nanoparticles using small angle neutron scattering." Z. Luo*, Y. Yang, A. Radulescu, J. Kohlbrecher, T. Darwish, Q. K. Ong, S. Guldin, F. Stellacci*. Chem. Mater., 31, no. 17 (2019): 6750-6758

[8] "Digital light 3D printing of customized bioresorbable airway stents with silicone-like mechanical properties." N. Paunović, Y. Bao, F. Coulter, K. Masania, A. Geks, K. Klein, A. Rafsanjani, J. Cadalbert, P. W. Kronen, N. Kleger, A. Karol, Z. Luo, F. Rüber, D. Brambilla, B. von Rechenberg, D. Franzen, A. R. Studart, J-C Leroux. Sci. Adv., 7, (2021): eabe9499

[9] "Continuous color tuning of single-fluorophore emission via polymerization-mediated through-space charge transfer."  S. Ye, T. Tian, A.J. Christofferson, S. Erikson S, J. Jagielski, Z. Luo, S. Kumar, C-J Shih, J-C Leroux, Bao Y. Sci. Adv., 7, (2021): eabd1794.

[10] "Solvent-Free Three-Dimensional Printing of Biodegradable Elastomers Using Liquid Macrophotoinitiators." M. Sandmeier, N. Paunović, R. Conti, L. Hofmann, J. Wang, Z. Luo, K. Masania, N. Wu, N. Kleger, F. B. Coulter, A. R. Studart, H. Grützmacher, J-C Leroux, Y. Bao, Macromolecules, 54, no. 17 (2021), 7830–7839

[11] "Quantification of surface composition and segregation on AuAg bimetallic nanoparticles by MALDI MS." S. Liao, Z. Luo, J. Metternich, R. Zenobi, F. Stellacci. Nanoscale, 12 (2020): 22639-22644

[12] "Comparative characterization of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy." Y. Yang, S. Liao, Z. Luo, R. Qi, NM Fhionnlaoich, F. Stellacci, S. Guldin. Nanoscale,12 (2020): 12007-12013

[13] "Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies." K. Anna, S. R. Mulay, M. Motrapu, Z. Luo, H-J Anders, M. E. Ivarsson, J-C Leroux. ‎Adv. Sci (2020): 1903337

[14] "Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture." S. Simona, C. Martinelli, A. Palazzo, R. M. Iacobazzi, M. Perrone, Q. K. Ong, Z. Luo et al. PLoS One,15, no. 3 (2020): e0224002.

[15] "Synthesis and Characterization of Amphiphilic Gold Nanoparticles." P. Guven, P. Silva, Z. Luo, U. Cendrowska, M. Gasbarri, S. Jones, F. Stellacci. J. Vis. Exp., 149 (2019): e58872

[16] "On the van der Waals interactions of n-alkanethiol covered Surfaces: From planar to curved surfaces." F. Cometto, Z. Luo, S. Zhao, J. Olmos-Asar, M. Mariscal, Q. Ong, K. Kern, F. Stellacci, and M. Lingenfelder. Angew. Chem., Int. Ed. 129, no. 52 (2017): 16753-16757.

[17] "Freestanding Ultrathin Nanoparticle Membranes Assembled at Transient Liquid–Liquid Interfaces." B. Le Ouay, S. Guldin, Z. Luo, S. Allegri, and F. Stellacci. Adv. Mat. Interfaces, 3, no. 15 (2016): 1600191

[18] "Glutathione as the end capper for cyclodextrin/PEG polyrotaxanes." Q. Song, Z. Luo, X. Tong, Y. Du, and Y. Huang. Chinese J. Polym. Sci., 32, no. 8 (2014): 1003-1009.