师资

帅世民
助理教授
助理教授
0755-88015015
shuaism@sustech.edu.cn

个人简介:

帅世民,南方科技大学医学院助理教授、博士生导师。2014年本科毕业于浙江大学生命科学学院,2019年博士毕业于多伦多大学分子遗传学系和安大略省癌症研究所(OICR),后赴欧洲分子生物学实验室海德堡总部(EMBL-Heidelberg)和欧洲生物信息学研究所(EMBL-EBI)进行由欧盟玛丽·居里学者(MSCA)项目联合资助的博士后研究(EIPOD4),并于2021年秋季全职回国组建计算组学(Computational OmicsCOmics)实验室。主要从事计算生物学、生物信息学、基因组学等领域的研究。其与癌症基因组学、计算组学工具研发等相关的研究成果发表在了Nature及其子刊上,相关论文总被引超过1000次,h-index10Google Scholar20219月)。


教育背景:

2014-2019:多伦多大学,计算生物学,博士,加拿大

 

2010-2014:浙江大学,生物科学,本科,中国

 

工作经历:

2021-至今:南方科技大学,医学院,人类细胞生物和遗传学系,助理教授,中国

 

2020-2021:欧洲生物信息学研究所(EMBL-EBI),联合博士后,英国

 

2020-2021:欧洲分子生物学实验室(EMBL),EIPOD4博士后(玛丽·居里学者联合资助),德国

 

2015-2019:安大略省癌症研究所(OICR),计算生物学项目,博士生研究员,加拿大

 

获奖情况及荣誉:

2020: EIPOD4 Fellowship co-funded by Marie-Skłodowska Curie Actions

 

2019: Canadian Cancer Society Travel Award

 

研究领域:

1.     生物信息学和计算生物学

2.     全尺度遗传变异与人类疾病的关联分析

3.     癌症基因组学和癌症生态系统研究

4.     多组学数据分析与新型组学数据分析工具研发


发表论文:

1.      Shuai S*, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD* & PCAWG Consortium (2020) Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat. Commun. 11: 734–734

2.      Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E & Stein LD (2019) The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature 574: 712–716

3.      Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, et al (2020) Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature 578: 102–111

4.      Zhu H, Uusküla-Reimand L, Isaev K, Wadi L, Alizada A, Shuai S, Huang V, Aduluso-Nwaobasi D, Paczkowska M, Abd-Rabbo D, Ocsenas O, Liang M, Thompson JD, Li Y, Ruan L, Krassowski M, Dzneladze I, Simpson JT, Lupien M, Stein LD, et al (2020) Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks. Mol. Cell 77: 1-15

5.      Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, et al (2019) Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature 574: 707–711

6.      Feigin ME, Garvin T, Bailey P, Waddell N, Chang DK, Kelley DR, Shuai S, Gallinger S, McPherson JD, Grimmond SM, Khurana E, Stein LD, Biankin AV, Schatz MC & Tuveson DA (2017) Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nat. Genet. 49: 825–833

7.      ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium [including Shuai S] (2020) Pan-cancer analysis of whole genomes. Nature 578: 82–93

8.      Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS, PCAWG Drivers and Functional Interpretation Group [including Shuai S], Johnson R & PCAWG Consortium (2020) Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Communications biology 3: 56–56

9.      Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J & PCAWG Consortium (2020) Integrative pathway enrichment analysis of multivariate omics data. Nat. Commun. 11: 735–735

10.  Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, et al, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J, Stuart JM, Raphael BJ & PCAWG Consortium (2020) Pathway and network analysis of more than 2500 whole cancer genomes. Nat. Commun. 11: 729–729