实验室主页：http://wulab.bme.sustech.edu.cn/

研究方向：

1）光学分子探针与超分辨光学成像
2）近红外荧光分子和深层组织成像
3）生物光学传感器及健康监测系统

教育背景

1994-1998 齐鲁工业大学材料科学与工程学院 本科
1998-2001 吉林大学材料科学与工程学院 硕士
2001-2004 中科院长春光机与物理研究所 凝聚态物理博士
2005-2008 美国克莱姆森大学化学系 物理化学博士

工作经历

2004-2005 美国克莱姆森大学物理系 博士后
2008-2011 美国华盛顿大学化学系 博士后
2011-2016 吉林大学电子科学与工程学院 教授
2016-至今 南方科技大学生物医学工程系 教授

项目负责人

2023-2027 国家自然科学基金重点项目 “活体深层脑组织近红外二区超分辨成像研究”

2020-2025 国家重点研发计划课题 “恶性消化系肿瘤特异性分子探针的精确核素标记与方法学研究”

2019-2024 深圳市孔雀团队项目 “脑瘤靶向探针及诊疗技术”

2014-2018 国家自然科学基金重点项目 “开关/闪烁可控聚合物量子点的设计制备及纳米分辨动态光学成像研究”
2013-2015 国家自然科学优秀青年基金项目 “生物医学光子学”

发表论文

1. Mi, F.; Liu, Z.; Wang, X.; Wang, Y.; Yang, J.; Wang, Z.; Yin, S.; Fang, X.; Shu, P.*; Zhang, X.*; Wu, C.*, Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing. Angewandte Chemie International Edition, 2024, 63(29), e202402133.

2. Li, D.; Shi, T.; Xiao, Y.; Wu C.*, Sensorless Adaptive Optics in the Second Near-Infrared Window for Deep Vascular Imaging In Vivo. Optics Letters, 2024, 49(14), 4002-4005.

3. Chen, D.; Qi, W.; Liu, Y.; Yang, Y.; Shi, T.; Wang, Y.; Fang, X.; Wang, Y.; Xi, L.*; Wu, C.*, Near-Infrared II Semiconducting Polymer Dots: Chain Packing Modulation and High-Contrast Vascular Imaging in Deep Tissues. ACS Nano, 2023, 17 (17), 17082-17094.

4. Liu, J.; Liu, Z.; Mi, F.; Yao, Z.; Fang, X.; Wang, Y.; Zhao, Z.*; Wu, C.*, Fluorescence Lifetime Multiplex Imaging in Expansion Microscopy with Tunable Donor–Acceptor Polymer Dots. Chemical & Biomedical Imaging, 2023, 1 (6), 550–557.

5. Wang, C.; Sun, Y.; Huang, S.; Wei, Z.; Tan, J.; Wu, C.*; Chen, Q.*; Zhang X.*, Self-Immolative Photosensitizers for Self-Reported Cancer Phototheranostics. Journal of the American Chemical Society, 2023, 145(24), 13099-13113.

6. Zhang, Z.; Li, W.; Liu, Y.; Fang, X.; Wu, C.*, Semiconducting Polymer Nanoparticles in the Second Near-Infrared Region for Biomedical Imaging and Therapy. Advanced Optical Materials, 2023, 11(11), 2202052.

7. Liu, S.; Liu, Y.; Zhang, Z.; Wang, X.; Yang, Y.; Sun, K.; Yu, J.; Chiu, D.T.; Wu, C.*, Near-Infrared Optical Transducer for Dynamic Imaging of Cerebrospinal Fluid Glucose in Brain Tumor. Analytical Chemistry, 2022, 94, 14265–14272.

8. Liu, J.; Fang, X.; Zhang, Z.; Liu, Z.; Liu, J.; Sun, K.; Yuan, Z.; Yu, J.; Chiu, D.T.; Wu, C.*, Long-Term In Vivo Glucose Monitoring by Polymer-Dot Transducer in an Injectable Hydrogel Implant. Analytical Chemistry, 2022, 94(4), 2195–2203.

9. Ao, J.; Fang, X.; Mao, X.; Ling, J.; Kang, H.; Park, S.; Wu, C.*, Ji, M.*, Switchable Stimulated Raman Scattering Microscopy with Photochromic Vibrational Probes. Nature Communications, 2021, 12(1), 3089.

10. Liu, J.; Fang, X.; Liu, Z.; Li, R.; Yang, Y.; Sun, Y.; Zhao, Z.; Wu, C.*, Expansion Microscopy with Multifunctional Polymer Dots. Advanced Materials, 2021,33(25), 2007854.

11. Chen, D.; Liu, Y.; Zhang, Z.; Liu, Z.; Fang, X.; He, S.; Wu, C.*, NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles. Nano Letters, 2021, 21(1) :798–805

12. Liu, Y.; Liu, J.; Chen, D.; Wang, X.; Zhang, Z.; Yang, Y.; Jiang, L.; Qi, W.; Ye, Z.; He, S.; Liu, Q.; Xi, L.; Zou, Y.*; Wu, C.*, Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging. Angewandte Chemie International Edition, 2020, 59 (47): 21049-21057.

13. Chen, H.; Wang, F.; Liu, M.; Qian, M.; Men, X.; Yao, C.; Xi, L.; Qin, W.; Qin, G.*; Wu, C.*, Near-Infrared Broadband Polymer-Dot Modulator with High Optical Nonlinearity for Ultrafast Pulsed Lasers. Laser & Photonics Reviews, 2019, 13(2), 1800326.

14. Sun, K.; Yang, Y.; Zhou, H.; Yin, S.; Qin, W.; Yu, J.; Chiu, D.T.; Yuan, Z.; Zhang, X.; Wu, C.*, Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone. ACS Nano, 2018, 12 (6), 5176–5184

15. Chang, K.; Liu, Z.; Fang, X.; Chen, H.; Men, X.; Yuan, Y.; Sun, K.; Zhang, X.; Yuan, Z.; Wu, C.*, Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters, 2017, 17 (7), 4323-4329.

16. Wu, C.; Chiu, D. T., Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine. Angewandte Chemie International Edition, 2013, 52 (11), 3086-3109.

17. Wu, C.; Hansen, S. J.; Hou, Q.; Yu, J.; Zeigler, M.; Jin, Y.; Burnham, D. R.; McNeill, J. D.; Olson, J. M.; Chiu, D. T., Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting. Angewandte Chemie International Edition, 2011, 50 (15), 3430-3434.

18. Wu, C.; Schneider, T.; Zeigler, M.; Yu, J.; Schiro, P. G.; Burnham, D. R.; McNeill, J. D.; Chiu, D. T., Bioconjugation of Ultrabright Semiconducting Polymer Dots for Specific Cellular Targeting. Journal of American Chemical Society, 2010, 132 (43), 15410-15417.

19. Wu, C.; Jin, Y.; Schneider, T.; Burnham, D. R.; Smith, P. B.; Chiu, D. T., Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry. Angewandte Chemie International Edition, 2010, 49 (49), 9436-9440.

20. Wu, C.; Bull, B.; Christensen, K.; McNeill, J., Ratiometric Single‐Nanoparticle Oxygen Sensors for Biological Imaging. Angewandte Chemie International Edition, 2009, 48 (15), 2741-2745.

21. Wu, C.; Zheng, Y.; Szymanski, C.; McNeill, J., Energy Ttransfer in a Nanoscale Multichromophoric System: Fluorescent Dye-Doped Conjugated Polymer Nanoparticles. Journal of Physical Chemistry C, 2008, 112(6), 1772-1781.

22. Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J., Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging. ACS Nano, 2008, 2 (11), 2415-2423.

23. Wu, C.; Szymanski, C.; Cain, Z.; McNeill, J., Conjugated Polymer Dots for Multiphoton Fluorescence Imaging. Journal of American Chemical Society, 2007, 129 (43), 12904-12905.

24. Wu, C.; Peng, H.; Jiang, Y.; McNeill, J., Energy Transfer Mediated Fluorescence from Blended Conjugated Polymer Nanoparticles. Journal of Physical Chemistry B, 2006, 110(29), 14148-14154.

25. Wu, C.; Szymanski, C.; McNeill, J., Preparation and Encapsulation of Highly Fluorescent Conjugated Polymer Nanoparticles. Langmuir, 2006, 22(7), 2956-2960.