个人简介：

南方科技大学医学院副教授、研究员，博士生导师。2009年本科毕业于华东理工大学，2014年博士毕业于中科院大连化学物理研究所。随后分别在The Scripps Research Institute和Johns Hopkins University进行博士后研究。在Cell, Cancer Cell, Cell Host & Microbe, Nature Communications, Nature Protocols, Science Translational Medicine, Cell Reports等期刊上发表 18 篇研究论文，以第一作者身份在Cell, Nature Communications, Nature Protocols等期刊上发表9篇研究论文。2022年8月加入南方科技大学医学院并组建研究课题组。

教育背景：

2005.09 - 2009.07，华东理工大学，学士学位    

2009.09 - 2014.07，大连化学物理研究所，博士学位

工作经历：

2014.08 - 2019.01，斯克里普斯研究所，博士后

2019.02 - 2022.07，约翰斯霍普金斯大学，博士后

2022.08 - 现在，南方科技大学医学院，副教授

获奖情况及荣誉：

2022年约翰斯霍普金斯大学病理系优秀青年学者奖

2018年Scripps CHAVI-ID优秀青年学者奖

2014年延长石油优秀博士奖学金

研究领域：

蛋白质谱新方法、新技术的开发及其在理解重要生物学问题及治疗人类疾病中的应用

发表论文：

1. Liwei Cao*, Chen Huang*, Daniel Cui Zhou*, Yingwei Hu, T Mamie Lih, Sara R Savage, Karsten Krug, David J Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda V Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D Jewell, Galen Hostetter, Chelsea J Newton, Qing Kay Li, Michael H Roehrl, David Fenyö, Pei Wang, Alexey I Nesvizhskii, D R Mani, Gilbert S Omenn, Emily S Boja, Mehdi Mesri, Ana I Robles, Henry Rodriguez, Oliver F Bathe, Daniel W Chan, Ralph H Hruban, Li Ding, Bing Zhang, Hui Zhang, Clinical Proteomic Tumor Analysis Consortium. (2021) Proteogenomic Characterization of Pancreatic Ductal Adenocarcinoma. Cell, 184(19): 5031-5052. *: Co-first author.

2.  Liwei Cao*, T Mamie Lih*, Yingwei Hu, Michael Schnaubelt, Shao-Yung Chen, Yangying Zhou, Chuanyu Guo, Mingming Dong, Weiming Yang, Rodrigo Vargas Eguez, Lijun Chen, David J Clark, Akrit Sodhi, Qing Kay Li, Hui Zhang. (2022) Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis. Nature Communications, 13: 3910. *: Co-first author.

3. Liwei Cao, Jolene K Diedrich, Yuanhui Ma, Nianshuang Wang, Matthias Pauthner, Sung-Kyu Robin Park, Claire M Delahunty, Jason S McLellan, Dennis R Burton, John R Yates, James C Paulson. (2018) Global site-specific analysis of glycoprotein N-glycan processing. Nature Protocols, 13(6): 1196-1212.

4. Liwei Cao*, Matthias Pauthner*, Raiees Andrabi, Kimmo Rantalainen, Zachary Berndsen, Jolene K Diedrich, Sergey Menis, Devin Sok, Raiza Bastidas, Sung-Kyu Robin Park, Claire M Delahunty, Lin He, Javier Guenaga, Richard T Wyatt, William R Schief, Andrew B Ward, John R Yates, Dennis R Burton, James C Paulson. (2018) Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer. Nature Communications, 9(1): 3693. *: Co-first author.

5. Liwei Cao, Jolene K Diedrich, Daniel W Kulp, Matthias Pauthner, Lin He, Sung-Kyu Robin Park, Devin Sok, Ching Yao Su, Claire M Delahunty, Sergey Menis, Raiees Andrabi, Javier Guenaga, Erik Georgeson, Michael Kubitz, Yumiko Adachi, Dennis R Burton, William R Schief, John R Yates III, James C Paulson. (2017) Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. Nature Communications, 8: 14954.

6. Liwei Cao, Long Yu, Zhimou Guo, Aijin Shen, Yunü Guo, Xinmiao Liang. (2014) N-Glycosylation site analysis of proteins from Saccharomyces cerevisiae by using hydrophilic interaction liquid chromatography-based enrichment, parallel deglycosylation, and mass spectrometry. Journal of Proteome Research, 13(3): 1485-93.

7. Liwei Cao*, Ye Zhang*, Linlin Chen, Aijin Shen, Xingwang Zhang, Shifang Ren, Jianxin Gu, Long Yu and Xinmiao Liang. (2014) Sample preparation for mass spectrometric analysis of human serum N-glycans using hydrophilic interaction chromatography-based solid phase extraction. Analyst, 139: 4538-4546. *: Co-first author.

8. Liwei Cao, Long Yu, Zhimou Guo, Xiuling Li, Xinya Xue, and Xinmiao Liang. (2013) Application of a strong anion exchange material in electrostatic repulsion-hydrophilic interaction chromatography for selective enrichment of glycopeptides. Journal of Chromatography A, 1299: 18-24.

9. Liwei Cao, Danhua Yu, Xinliang Wang, Yanxiong Ke, Yu Jin , Xinmiao Liang. (2011) The development of an evaluation method for capture columns used in two-dimensional liquid chromatography. Analytica Chimica Acta, 706: 184-190.

10. Chen Huang, Lijun Chen, Sara R Savage, Rodrigo Vargas Eguez, Yongchao Dou, Yize Li, Felipe da Veiga Leprevost, Eric J Jaehnig, Jonathan T Lei, Bo Wen, Michael Schnaubelt, Karsten Krug, Xiaoyu Song, Marcin Cieślik, Hui-Yin Chang, Matthew A Wyczalkowski, Kai Li, Antonio Colaprico, Qing Kay Li, David J Clark, Yingwei Hu, Liwei Cao, Jianbo Pan, Yuefan Wang, Kyung-Cho Cho, Zhiao Shi, Yuxing Liao, Wen Jiang, Meenakshi Anurag, Jiayi Ji, Seungyeul Yoo, Daniel Cui Zhou, Wen-Wei Liang, Michael Wendl, Pankaj Vats, Steven A Carr, D R Mani, Zhen Zhang, Jiang Qian, Xi S Chen, Alexander R Pico, Pei Wang, Arul M Chinnaiyan, Karen A Ketchum, Christopher R Kinsinger, Ana I Robles, Eunkyung An, Tara Hiltke, Mehdi Mesri, Mathangi Thiagarajan, Alissa M Weaver, Andrew G Sikora, Jan Lubiński, Małgorzata Wierzbicka, Maciej Wiznerowicz, Shankha Satpathy, Michael A Gillette, George Miles, Matthew J Ellis, Gilbert S Omenn, Henry Rodriguez, Emily S Boja, Saravana M Dhanasekaran, Li Ding, Alexey I Nesvizhskii, Adel K El-Naggar, Daniel W Chan, Hui Zhang, Bing Zhang, Clinical Proteomic Tumor Analysis Consortium. (2021) Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell, 39(3):361-379.

11. Andrew J Thompson, Liwei Cao, Yuanhui Ma, Xiaoning Wang, Jolene K Diedrich, Chika Kikuchi, Shelby Willis, Charli Worth, Ryan McBride, John R Yates, James C Paulson. (2020) Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by Lectins. Cell Host Microbe, 27(5): 725-735.

12. Kimmo Rantalainen, Zachary T Berndsen, Sasha Murrell, Liwei Cao, Oluwarotimi Omorodion, Jonathan L Torres, Mengyu Wu, Jeffrey Umotoy, Jeffrey Copps, Pascal Poignard, Elise Landais, James C Paulson, Ian A Wilson, Andrew B Ward. （2018） Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Reports, 23(11): 3249-3261.

13. Colin Havenar-Daughton, Anita Sarkar, Daniel W Kulp, Laura Toy, Xiaozhen Hu, Isaiah Deresa, Oleksandr Kalyuzhniy, Kirti Kaushik, Amit A Upadhyay, Sergey Menis, Elise Landais, Liwei Cao, Jolene K Diedrich, Sonu Kumar, Torben Schiffner, Samantha M Reiss, Grégory Seumois, John R Yates, James C Paulson, Steven E Bosinger, Ian A Wilson, William R Schief, Shane Crotty. (2018) The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Science Translational Medicine, 10(448): eaat0381.

14. Aijin Shen, Zhimou Guo, Long Yu, Liwei Cao and Xinmiao Liang. (2011) A novel zwitterionic HILIC stationary phase based on “thiol-ene” click chemistry between cysteine and vinyl silica. Chemical Communications, 47: 4550-4552.

15. Chitra Upadhyay, Roya Feyznezhad, Liwei Cao, Kun-Wei Chan, Kevin Liu, Weiming Yang, Hui Zhang, Jason Yolitz, James Arthos, Arthur Nadas, Xiang-Peng Kong, Susan Zolla-Pazner, Catarina E. Hioe. (2020) Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes. PLOS Pathogens, 16(12): e1009185.

16. Yangying Zhou, T. Mamie Lih, Jianbo Pan, Naseruddin Höti, Mingming Dong, Liwei Cao, Yingwei Hu, Kyung-Cho Cho, Shao-Yung Chen, Rodrigo Vargas Eguez, Edward Gabrielson, Daniel W. Chan, Hui Zhang, Qing Kay Li. (2020) Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets. Journal of Hematology & Oncology, 13: 170.