师资

董涛
教授
dongt@sustech.edu.cn

个人简介:

现任南方科技大学生命科学学院教授。本科毕业于山东大学,博士毕业于加拿大麦克马斯特大学,在哈佛大学医学院进行博士后研究并获得加拿大班庭奖学金。在加拿大卡尔加里大学先后任助理教授至终身正教授。曾获得加拿大创新基金、健康研究基金和自然科学基金等总额300万加元的资助,现主持国家自然基金重点项目和重点研发课题等多个项目。

(https://orcid.org/0000-0003-3557-1850)


研究领域:

研究方向包括病原细菌与宿主的相互作用、抗生素耐药性机理、和蛋白质VI型分泌系统(T6SS)的分泌机理、功能及菌群的调控等。


工作经历:

2011-2013 Harvard Medical School, Postdoctoral Fellow

2013-2021 University of Calgary, Assistant to Full Professor

2017-2021 Shanghai Jiao Tong University, Principle Investigator


学习经历:

1999-2003 Shandong University, BSc

2004-2010 McMaster University, PhD


所获荣誉:

2012-2014  Banting Fellow

2014-2024 Canada Research Chair in Molecular Ecology of Waterborne Microbes


代表文章: 

(1)  Hersch, S. J.; Lam, L.; Dong, T. G. Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase. mBio 2021, 12 (4), 2021.05.11.443660. https://doi.org/10.1128/mBio.01115-21.

(2)  Manera, K.; Caro, F.; Li, H.; Pei, T.-T.; Hersch, S. J.; Mekalanos, J. J.; Dong, T. G. Sensing of Intracellular Hcp Levels Controls T6SS Expression in Vibrio Cholerae. Proc. Natl. Acad. Sci. 2021, 118 (25), e2104813118. https://doi.org/10.1073/pnas.2104813118.

(3)  Hersch, S. J.; Watanabe, N.; Stietz, M. S.; Manera, K.; Kamal, F.; Burkinshaw, B.; Lam, L.; Pun, A.; Li, M.; Savchenko, A.; Dong, T. G. Envelope Stress Responses Defend against Type Six Secretion System Attacks Independently of Immunity Proteins. Nat. Microbiol. 2020, 5 (5), 706–714. https://doi.org/10.1038/s41564-020-0672-6.

(4)  Pei, T.-T.; Li, H.; Liang, X.; Wang, Z.-H.; Liu, G.; Wu, L.-L.; Kim, H.; Xie, Z.; Yu, M.; Lin, S.; Xu, P.; Dong, T. G. Intramolecular Chaperone-Mediated Secretion of an Rhs Effector Toxin by a Type VI Secretion System. Nat. Commun. 2020, 11 (1), 1865. https://doi.org/10.1038/s41467-020-15774-z.

(5)  Stietz, M. S.; Liang, X.; Li, H.; Zhang, X.; Dong, T. G. TssA–TssM–TagA Interaction Modulates Type VI Secretion System Sheath-Tube Assembly in Vibrio Cholerae. Nat. Commun. 2020, 11 (1), 5065. https://doi.org/10.1038/s41467-020-18807-9.

(6)  Liang, X.; Kamal, F.; Pei, T.-T.; Xu, P.; Mekalanos, J. J.; Dong, T. G. An Onboard Checking Mechanism Ensures Effector Delivery of the Type VI Secretion System in Vibrio Cholerae. Proc. Natl. Acad. Sci. 2019, 116 (46), 23292–23298. https://doi.org/10.1073/pnas.1914202116.

(7)  Burkinshaw, B. J.; Liang, X.; Wong, M.; Le, A. N. H.; Lam, L.; Dong, T. G. A Type VI Secretion System Effector Delivery Mechanism Dependent on PAAR and a Chaperone–Co-Chaperone Complex. Nat. Microbiol. 2018, 3 (5), 632–640. https://doi.org/10.1038/s41564-018-0144-4.

(8)  Liang, X.; Moore, R.; Wilton, M.; Wong, M. J. Q.; Lam, L.; Dong, T. G. Identification of Divergent Type VI Secretion Effectors Using a Conserved Chaperone Domain. Proc. Natl. Acad. Sci. 2015, 112 (29), 9106–9111. https://doi.org/10.1073/pnas.1505317112.